Tucatinib
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- ₹0
- Product name: Tucatinib
- CAS: 937263-43-9
- MF: C26H24N8O2
- MW: 480.52
- EINECS:200-001-8
- MDL Number:MFCD22380467
- Synonyms:ONT-380);N4-(4-([1;N6-(4,5-Dihydro-4,4-dimethyl-2-oxazolyl)-N4-[3-methyl-4-([1,2,4]triazolo[1,5-a]pyridin-7-yloxy)phenyl]-4,6-quinazolinediamine;Irbinitinib;Irbinitinib(ARRY380);(R)-N6-(4-Methyl-4;5-dihydrooxazol-2-yl)-N4-(3-Methyl-4-(thiazol-2-ylMethoxy)phenyl)quinazoline-4;6-diaMine
Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
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Properties
Density :1.41±0.1 g/cm3(Predicted)
storage temp. :Store at -20°C
solubility :DMF:1.0(Max Conc. mg/mL);2.08(Max Conc. mM)
DMSO:49.0(Max Conc. mg/mL);101.97(Max Conc. mM)
DMSO:PBS (pH 7.2) (1:2):0.33(Max Conc. mg/mL);0.69(Max Conc. mM) form :A crystalline solid
pka :6.61±0.70(Predicted)
color :White to yellow
InChIKey :SDEAXTCZPQIFQM-UHFFFAOYSA-N
SMILES :N1=C2C(C=C(NC3=NC(C)(C)CO3)C=C2)=C(NC2=CC=C(OC3C=CN4N=CN=C4C=3)C(C)=C2)N=C1
storage temp. :Store at -20°C
solubility :DMF:1.0(Max Conc. mg/mL);2.08(Max Conc. mM)
DMSO:49.0(Max Conc. mg/mL);101.97(Max Conc. mM)
DMSO:PBS (pH 7.2) (1:2):0.33(Max Conc. mg/mL);0.69(Max Conc. mM) form :A crystalline solid
pka :6.61±0.70(Predicted)
color :White to yellow
InChIKey :SDEAXTCZPQIFQM-UHFFFAOYSA-N
SMILES :N1=C2C(C=C(NC3=NC(C)(C)CO3)C=C2)=C(NC2=CC=C(OC3C=CN4N=CN=C4C=3)C(C)=C2)N=C1
Safety Information
Symbol(GHS): |
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Signal word: | Warning | ||||||||||||||||||||||||||||
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Description
Tucatinib is also known as ARRY-380 or Irbinitinib. ARRY-380 is an orally inhibitor of human epidermal growth factor receptor tyrosine kinase ErbB-2 (also called HER2) with potential antineoplastic activity. It selectively binds to and inhibits the phosphorylation of ErbB-2, which may prevent the activation of ErbB-2 signal transduction pathways, resulting in growth inhibition and death of ErbB-2-expressing tumor cells. ErbB-2 is overexpressed in a variety of cancers and plays an important role in cellular proliferation and differentiation. Therefore, ARRY-380 may be an alternative treatmentmethod for the treatment of HER2+ cancers.More related product prices
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- Dacomitinib (PF299804)
₹5000-14200 - AG 1478 HYDROCHLORIDE
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