Tucatinib
Tucatinib
- CAS:
- 937263-43-9
- MF:
- C26H24N8O2
- MW:
- 480.52
Suppliers by country/region
Company Type
Properties
- Density
- 1.41±0.1 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- DMF:1.0(Max Conc. mg/mL);2.08(Max Conc. mM)
DMSO:49.0(Max Conc. mg/mL);101.97(Max Conc. mM)
DMSO:PBS (pH 7.2) (1:2):0.33(Max Conc. mg/mL);0.69(Max Conc. mM)
- form
- A crystalline solid
- pka
- 6.61±0.70(Predicted)
- color
- White to yellow
- InChIKey
- SDEAXTCZPQIFQM-UHFFFAOYSA-N
- SMILES
- N1=C2C(C=C(NC3=NC(C)(C)CO3)C=C2)=C(NC2=CC=C(OC3C=CN4N=CN=C4C=3)C(C)=C2)N=C1
Safety Information
- Symbol(GHS)
GHS07
- Signal word
- Warning
- Hazard statements
- H335-H315-H319
- Precautionary statements
- P261-P405-P305+P351+P338-P304+P340-P280
Use
Irbinitinib is also known as ARRY-380 or Tucatinib. ARRY-380 is an orally inhibitor of human epidermal growth factor receptor tyrosine kinase ErbB-2 (also called HER2) with potential antineoplastic activity. It selectively binds to and inhibits the phosphorylation of ErbB-2, which may prevent the activation of ErbB-2 signal transduction pathways, resulting in growth inhibition and death of ErbB-2-expressing tumor cells. ErbB-2 is overexpressed in a variety of cancers and plays an important role in cellular proliferation and differentiation. Therefore, ARRY-380 may be an alternative treatmentmethod for the treatment of HER2+ cancers.
1 India supplier list of "Tucatinib"
- Product Name:Tucatinib
- Products Intro:Purity: 98% | Package: 1 kg,5 kg, 10 kg,25kg and 1 MT
- Company Type: Manufacturer
- Country/Region: Hyderabad,INDIA
- Product Name:Tucatinib
- Products Intro:Brand:synzeal | Product Number:786018534
- Company Type: Trader
- Country/Region: Gujarat,INDIA
- Product Name:Irbinitinib
- Products Intro:Brand:ajchemicals | Product Number:JDH-31456 | Purity:98+%
- Company Type: Trader
- Country/Region: New Delhi,INDIA
- Product Name:Tucatinib
- Products Intro:Purity: 0.98 | Package: 10mg, 10g, 50g, 100g, 1kg, 5kg, 10kg
- Company Type: Trader
- Country/Region: CHINA
- Main Products: OLED & OPV,APIs,Organic Chemicals,Peptides,BioChemicals
- Product Name:Tucatinib
- Products Intro:Purity: More Than 99%|Package: 1g;0.00;USD
- Company Type: Trader
- Country/Region: CHINA
- Main Products: Pharmaceutical Chemicals,Apis,Pharmaceutical Intermediates,Electronic Chemicals,OLED Intermediates
$0.00/ 1g
- Product Name:Irbinitinib
- Products Intro:Purity: 98% | Package: 1KG
- Company Type: Trader
- Country/Region: CHINA
- Main Products: 5-Heptylresorcinol,Methyl 2-heptyl-4,6-dihydroxybenzoate,Cannabinoids Precursors,2,4-dihydroxy-6-propyl-benzoic acid methyl ester,Benzoic acid, 2-hexyl-4,6-dihydroxy-, methyl ester
$0.00/ 1KG
- Product Name:Irbinitinib
- Products Intro:Purity: 99% | Package: 25KG;5KG;1KG
- Company Type: Trader
- Country/Region: CHINA
- Product Name:Irbinitinib(ARRY 380)
- Products Intro:Purity: 98% | Package: 10MG;50MG;100MG,1G,5G,10G.100G
- Company Type: Reagent
- Country/Region: CHINA
- Product Name:Irbinitinib
- Products Intro:Purity: 0.98 | Package: 1KG;10KG;50KG
- Company Type: Trader
- Country/Region: CHINA
- Product Name:Irbinitinib
- Products Intro:Purity: 0.98 | Package: 100mg | CustNote: BOC Sciences also provides custom synthesis services for Irbinitinib.
- Company Type: Trader
- Country/Region: UNITED STATES