CO-1686
CO-1686
- CAS:
- 1374640-70-6
- MF:
- C27H28F3N7O3
- MW:
- 555.55
Suppliers by country/region
Company Type
Properties
- Melting point:
- 202 - 205°C (dec.)
- Density
- 1.372±0.06 g/cm3(Predicted)
- storage temp.
- Amber Vial, -20°C Freezer, Under inert atmosphere
- solubility
- DMSO (Slightly), Methanol (Slightly)
- form
- Solid
- pka
- 13.23±0.70(Predicted)
- color
- Off-White
Safety Information
- Symbol(GHS)
GHS07
- Signal word
- Warning
- Hazard statements
- H302-H315-H319-H335
- Precautionary statements
- P261-P264-P270-P271-P280-P301+P312-P330-P302+P352-P321-P304+P340-P305+P351+P338-P332+P313-P362+P364-P337+P313-P403+P233-P405-P501
- Risk Statements
- 23-25-36
- Safety Statements
- 24
- HS Code
- 29335990
Use
CO-1686 inhibited the p-EGFR in EGFR-expressing cells with an IC50 ranging from 62 to 187 nM while inhibiting EGFR phosphorylation. In three WT EGFR-expressing cells, the IC50 is larger than 2,000 nM. CO-1686 can selectively inhibit the growth of mutant EGFR expressing NSCLC cells with a GI50 ranging from 7 to 32 nM while inducing apoptosis. The CO-1686-resistant NSCLC cell line exhibited a signal for epithelial-mesenchymal transition and increased susceptibility to AKT inhibitors.
1 India supplier list of "CO-1686"
- Product Name:CO-1686 >95%
- Products Intro:Brand：Glrinnovations | OriginalID：GLR19.089864
- Company Type: Trader
- Country/Region: New Delhi,INDIA
- Product Name:CO-1686
- Products Intro:Brand:ajchemicals | Product Number:JDH-27794 | Purity:98+%
- Company Type: Trader
- Country/Region: New Delhi,INDIA
- Product Name:RociletinibD8
- Products Intro:Brand:clearsynth | Product Number:CS-O-15594
- Company Type: Trader
- Country/Region: Hyderabad,INDIA
- Product Name:Rociletinib
- Products Intro:Purity: NLT 98% | Package: 1G;1KG;100KG
- Company Type: Trader
- Country/Region: CHINA
- Main Products: 1159983-30-8,89466-59-1,149739-51-5,104901-79-3,10541-83-0
- Product Name:CO-1686
- Products Intro:Purity: 0.99 | Package: 5MG;10MG;50MG;100MG,1G,5G
- Company Type: Reagent
- Country/Region: CHINA
- Product Name:Rociletinib
- Products Intro:Package: 100mg | CustNote: BOC Sciences also provides custom synthesis services for Rociletinib.
- Company Type: Trader
- Country/Region: UNITED STATES
- Product Name:CO-1686
- Products Intro:Purity: 0.98 | Package: 1kg，2kg，5kg，10kg，25kg
- Company Type: Trader
- Country/Region: CHINA
- Main Products: 2,7-ADA,2,4,6-Trichloroaniline,TRIMETHYLOXONIUM TETRAFLUOROBORATE,Zinc sulfide,5-HEXEN-1-OL
- Product Name:rociletinib
- Products Intro:Purity: 0.99 | Package: 1kg; 25kg; or larger package as required | CustNote: pharmaceutical intermediates；Chemical Intermediate
- Company Type: Trader
- Country/Region: CHINA
- Main Products: Specialty chemicals,OLED materials,Custom synthesis service
- Product Name:CO-1686
- Products Intro:Purity: 99.9% | Package: 25kgs/Drum;200kgs/Drum | CustNote: FDA GMP CEP Approved Manufacturer
- Company Type: Trader
- Country/Region: CHINA