OSI-420
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- ₹0
- Product name: OSI-420
- CAS: 183321-86-0
- MF: C21H21N3O4
- MW: 379.41
- EINECS:
- MDL Number:MFCD09841129
- Synonyms:CP 373420;OSI-420 (free base);Erlotinib O-DesMethyl Metabolite;Erlotinib iMpurity H;Desmethyl Erlotinib (CP-473420, OSI-420);6-O-Desmethyl Erlotinib 1;2-((4-((3-ethynylphenyl)amino)-7-(2-methoxyethoxy)quinazolin-6-yl)oxy)ethan-1-ol;2-((4-((3-Ethynylphenyl)amino)-7-(2-methoxyethoxy)quinazolin-6-yl)oxy)ethanol
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Properties
Melting point :140-142°C
Density :1.30
storage temp. :-20°C Freezer
solubility :insoluble in H2O; insoluble in EtOH; ≥51 mg/mL in DMSO
form :A crystalline solid
color :White to off-white
Density :1.30
storage temp. :-20°C Freezer
solubility :insoluble in H2O; insoluble in EtOH; ≥51 mg/mL in DMSO
form :A crystalline solid
color :White to off-white
Safety Information
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| Signal word: | Warning | ||||||||||||||
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Description
OSI-420 is a metabolite of Erlotinib. Erlontinib potently inhibits EGFR autophosphorylation in cultured human head and neck tumor cells, a cell line which exhibits high levels of EGFR. Erlotinib also inhibits the proliferation of PC-9 cell lines, which contain a deletion mutation on exon 19 of the EGFR gene. A combination of Erlotinib and rapamycin produced a synergistic inhibitory effect on cell growth.Related product price
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