Erlotinib D6 HCl
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- ₹0
- Product name: Erlotinib D6 HCl
- CAS: 1189953-78-3
- MF: C22H18ClD6N3O4
- MW: 435.933630668
- EINECS:
- MDL Number:MFCD09840535
- Synonyms:Erlotinib D6;Erlotinib Hydrochloride Impurity G;[2H6]-Erlotinib Hydrochloride;CP-358774 D6 hydrochloride;NSC 718781 D6 hydrochloride;OSI-774 D6 hydrochloride;Erlotiniβ-d6 Hydrochloride
Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
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Properties
storage temp. :Store at -20°C
solubility :DMSO: slightly, heated,Methanol: slightly soluble
form :A solid
color :White to off-white
solubility :DMSO: slightly, heated,Methanol: slightly soluble
form :A solid
color :White to off-white
Safety Information
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Signal word: | Warning | ||||||||||||||
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Description
Erlotinib-d6 (hydrochloride) contains six deuterium atoms located on the methoxy group. It is intended for use as an internal standard for the quantification of erlotinib by GC- or LC-MS. Erlotinib is a tyrosine kinase inhibitor that acts on the epidermal growth factor receptor (EGFR), inhibiting EGFR-associated kinase activity (IC50 = 2.5 μM). This inhibits tumor growth in human head and neck carcinoma (HN5) tumor xenografts in mice with an ED50 value of 9 mg/kg. Erlotinib also suppresses cyclin-dependent kinase 2 (Cdk2) activity in breast cancer cells (IC50 = 4.6 μM) and JAK2 mutant JAK2V617F (IC50 = 5 μM), which is associated with polycythemia vera, idiopathic myelofibrosis, and essential thrombocythemia. Formulations containing erlotinib are used to treat certain forms of cancer, including non-small cell lung cancer.More related product prices
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