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AZD 3759

AZD 3759 Structure
  • ₹0
  • Product name: AZD 3759
  • CAS: 1626387-80-1
  • MF: C22H23ClFN5O3
  • MW: 459.9
  • EINECS:1592732-453-0
  • MDL Number:MFCD29058564
  • Synonyms:AZD 3759;AZD3759;AZD-3759;(2R)-2,4-Dimethyl-1-piperazinecarboxylic acid 4-[(3-chloro-2-fluorophenyl)amino]-7-methoxy-6-quinazolinyl ester;HY-18750;azd3579;1-Piperazinecarboxylic acid, 2,4-dimethyl-, 4-[(3-chloro-2-fluorophenyl)amino]-7-methoxy-6-quinazolinyl ester, (2R)-;1-PIPERAZINECARBOXYLIC ACID, 2,4-DIMETHYL-, 4-[(3-CHLORO-2-FLUOROPHENYL)AMINO]-7-METHOXY-6-QUINAZOLINYL ESTER
Properties Safety Information Description
Manufacturer Product number Product description Packaging Price Updated Buy

Properties

Boiling point :571.4±50.0 °C(Predicted)
Density :1.358±0.06 g/cm3(Predicted)
storage temp. :Store at -20°C
solubility :≥23 mg/mL in DMSO; insoluble in H2O; ≥8.32 mg/mL in EtOH with ultrasonic
form :solid
pka :6.71±0.40(Predicted)
color :White to off-white
InChIKey :MXDSJQHFFDGFDK-CYBMUJFWSA-N
SMILES :N1(C(OC2C(OC)=CC3C(C=2)=C(NC2=CC=CC(Cl)=C2F)N=CN=3)=O)CCN(C)C[C@H]1C

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning GHS hazard pictograms P264, P270, P301+P312, P330, P501
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

AZD3759 is an EGFP inhibitor (Epidermal growth factor receptor tyrosine kinase inhibitor) with blood brain barrier (BBB) penetration. It has the potential for the treatment of non-small cell lung cancer (NSCLC), with brain metastases (BM) and leptomengingeal metastases (LM) since this type of cancer often contain a lot of activating mutations of the epidermal growth factor receptor (EGFR). It has excellent capability of penetrating the blood brain barrier to reach the central nervous system. 

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Related product price

Suppliers and manufacturers

Shijiazhuang Tongyang Import and Export Co., LTD
AZD3759
₹50.00 /1KG
AZD3759 CAS:1626387-80-1
Hebei Yanxi Chemical Co., Ltd.
AZD3759
₹0.00 /1kg
AZD3759 CAS:1626387-80-1
career henan chemical co
AZD 3759
₹7.00 /1kg
AZD 3759 CAS: 1626387-80-1
A.J Chemicals
Jinan Good Medical Technology Co.,Ltd
AFINE CHEMICALS LIMITED
Henan Tianfu Chemical Co.,Ltd.
Hangzhou FandaChem Co.,Ltd.
ATK CHEMICAL COMPANY LIMITED
BOC Sciences