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ChemicalBook > Product Catalogue >API >Antineoplastic agents >Tinib Antineoplastic drugs >Mubritinib

Mubritinib

Mubritinib Structure
  • ₹6711.5 - ₹28500
  • Product name: Mubritinib
  • CAS: 366017-09-6
  • MF: C25H23F3N4O2
  • MW: 468.47
  • EINECS:
  • MDL Number:MFCD09954135
  • Synonyms:MUBRITINIB;1-(4-(4-((2-((1E)-2-(4-(Trifluoromethyl)phenyl)ethenyl)-4-oxazolyl)methoxy)phenyl)butyl)-1H-1,2,3-triazole;TAK 165;Mubritinib(TAK 165);(E)-1-(4-(4-((2-(4-(trifluoromethyl)styryl)oxazol-4-yl)methoxy)phenyl)butyl)-1H-1,2,3-triazole;1-(4-(4-((2-((1E)-2-(4-(Trifluoromethyl)phenyl)ethenyl)-4-oxazolyl)methoxy)phenyl)butyl)-1H-1,2,3-triazole Mubritinib (TAK 165);Mubritinib 1-(4-(4-((2-((1E)-2-(4-(Trifluoromethyl)phenyl)ethenyl)-4-oxazolyl)methoxy)phenyl)butyl)-1H-1,2,3-triazole;(E)-4-((4-(4-(1H-1,2,3-Triazol-1-yl)butyl)phenoxy)methyl)-2-(4-(trifluoromethyl)styryl)oxazole
Price4 Properties Safety Information Description
4 prices
Selected condition：

Brand

  • TCI Chemicals (India)
  • Sigma-Aldrich(India)

Package

  • 5MG
  • 25MG
  • 100MG
  • ManufacturerTCI Chemicals (India)
  • Product numberM3058
  • Product descriptionMubritinib
  • Packaging25MG
  • Price₹8800
  • Updated2022-05-26
  • Buy
  • ManufacturerTCI Chemicals (India)
  • Product numberM3058
  • Product descriptionMubritinib
  • Packaging100MG
  • Price₹28500
  • Updated2022-05-26
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberSML1312
  • Product descriptionMubritinib ≥98% (HPLC)
  • Packaging5MG
  • Price₹6711.5
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberSML1312
  • Product descriptionMubritinib ≥98% (HPLC)
  • Packaging25MG
  • Price₹27214.05
  • Updated2022-06-14
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
TCI Chemicals (India) M3058 Mubritinib 25MG ₹8800 2022-05-26 Buy
TCI Chemicals (India) M3058 Mubritinib 100MG ₹28500 2022-05-26 Buy
Sigma-Aldrich(India) SML1312 Mubritinib ≥98% (HPLC) 5MG ₹6711.5 2022-06-14 Buy
Sigma-Aldrich(India) SML1312 Mubritinib ≥98% (HPLC) 25MG ₹27214.05 2022-06-14 Buy

Properties

Melting point :158.0 to 162.0 °C
Boiling point :620.9±65.0 °C(Predicted)
Density :1.25±0.1 g/cm3(Predicted)
storage temp. :Store at +4°C
solubility :DMSO : 50 mg/mL (106.73 mM; Need ultrasonic)H2O : < 0.1 mg/mL (insoluble)
pka :1.45±0.10(Predicted)
form :powder to crystal
color :White to Gray to Brown

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning GHS hazard pictograms P264, P270, P301+P312, P330, P501
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H320 Causes eye irritation Serious eye damage/eye irritation Category 2B Warning P264, P305+P351+P338,P337+P313
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312 IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352 IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

Mubritinib is a selective inhibitor of the human epidermal growth factor receptor 2 (HER2), inhibiting HER2 phosphorylation with an IC50 value of 6 nM. It is without effect on EGFR, FGFR, PDGFR, JAK1, Src, and Blk (IC50 > 25 μM). Mubritinib inhibits the proliferation of breast, bladder, kidney, and prostate cancer cells in vitro and in vivo.

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Suppliers and manufacturers

career henan chemical co
Mubritinib
₹3.00 /3KG
Mubritinib CAS:366017-09-6
Dideu Industries Group Limited
Mubritinib USP/EP/BP
₹1.10 /1g
Mubritinib USP/EP/BP CAS:366017-09-6
A.J Chemicals TCI Chemicals (India) Pvt. Ltd.
ATK CHEMICAL COMPANY LIMITED
BOC Sciences
Chongqing Chemdad Co., Ltd
CONIER CHEM AND PHARMA LIMITED
Baoji Guokang Bio-Technology Co., Ltd.
Sinoway Industrial co., ltd.