GSK-2126458
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- ₹9417.75 - ₹37952.45
- Product name: GSK-2126458
- CAS: 1086062-66-9
- MF: C25H17F2N5O3S
- MW: 505.5
- EINECS:629-873-1
- MDL Number:MFCD16038929
- Synonyms:GSK2126458;GSK-2126458;GSK2126458; GSK-2126458;2,4-Difluoro-N-[2-methoxy-5-[4-(4-pyridazinyl)-6-quinolinyl]-3-pyridinyl]benzenesulfonamide;HYR-582;GSK212;2,4-Difluoro-N-[2-Methoxy-5-[4-(pyridazin-4-yl)quinolin-6-yl]pyridin-3-yl]benzenesulfonaMide;OMipalisib
2 prices
Selected condition：
Brand
- Sigma-Aldrich(India)
Package
- 10MG
- 50MG
- ManufacturerSigma-Aldrich(India)
- Product numberSML3161
- Product descriptionGSK2126458 ≥98% (HPLC)
- Packaging50MG
- Price₹37952.45
- Updated2022-06-14
- Buy
- ManufacturerSigma-Aldrich(India)
- Product numberSML3161
- Product descriptionGSK2126458 ≥98% (HPLC)
- Packaging10MG
- Price₹9417.75
- Updated2022-06-14
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | SML3161 | GSK2126458 ≥98% (HPLC) | 50MG | ₹37952.45 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | SML3161 | GSK2126458 ≥98% (HPLC) | 10MG | ₹9417.75 | 2022-06-14 | Buy |
Properties
Melting point :187-189℃
Boiling point :715.6±70.0 °C(Predicted)
Density :1.45
storage temp. :Refrigerator
solubility :Chloroform (Slightly), DMSO (Slightly), Methanol (Very Slightly, Heated)
form :Solid
pka :6.23±0.40(Predicted)
color :White to Pale Yellow
Boiling point :715.6±70.0 °C(Predicted)
Density :1.45
storage temp. :Refrigerator
solubility :Chloroform (Slightly), DMSO (Slightly), Methanol (Very Slightly, Heated)
form :Solid
pka :6.23±0.40(Predicted)
color :White to Pale Yellow
Safety Information
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| Signal word: | Danger | |||||||||||||||||||||
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Description
GSK2126458 is a potent inhibitor of phosphoinositide 3-kinase isoforms (Kis = 19, 130, 24, and 60 pM for p110α, β, δ, and γ, respectively). It also inhibits mTOR in both mTORC1 and mTORC2 (Kis = 180 and 300 nM, respectively), as well as several common mutant forms of p110α. GSK2126458 is orally bioavailable, displays favorable pharmacokinetics, and shows efficacy in tumor growth models. GSK2126458 positively combines with inhibitors of discoidin domain receptor 1 (DDR1) inhibitor DDR1-IN-1 to suppress the growth of SNU-1040 colorectal cancer cells.More related product prices
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Suppliers and manufacturers
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