AZD-8055
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- ₹0
- Product name: AZD-8055
- CAS: 1009298-09-2
- MF: C25H31N5O4
- MW: 465.54
- EINECS:-0
- MDL Number:MFCD16660191
- Synonyms:AZD 8055 [5-[2,4-Bis((3S)-3-methylmorpholin-4-yl)pyrido[2,3-d]pyrimidin-7-yl]-2-methoxyphenyl]methanol;AZD8055, >=98%;Propanoic acid, 2,2-dimethyl-, [5-(2,4-dichloropyrido[2,3-d]pyrimidin-7-yl)-2-methoxyphenyl]methyl ester;(5-{2,4-dichloropyrido[2,3-d]pyriMidin-7-yl}-2-Methoxyphenyl)Methyl 2,2-diMethylpropanoate;[5-[2,4-Bis((3S)-3-MethylMorpholin-4-yl)pyrido[;5-[2,4-Bis[(3S)-3-Methyl-4-Morpholinyl]pyrido[2,3-d]pyriMidin-7-yl]-2-MethoxybenzeneMethanol;CCG 168;AZD8055,AZD-8055
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Properties
Melting point :204 - 207°C
Boiling point :694.3±65.0 °C(Predicted)
Density :1.248
storage temp. :-20°C
solubility :Soluble in DMSO (up to 30 mg/ml)
form :Yellow powder.
pka :14.20±0.10(Predicted)
color :Yellow
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months.
Boiling point :694.3±65.0 °C(Predicted)
Density :1.248
storage temp. :-20°C
solubility :Soluble in DMSO (up to 30 mg/ml)
form :Yellow powder.
pka :14.20±0.10(Predicted)
color :Yellow
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months.
Safety Information
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Description
AZD 8055 is a potent, selective ATP-competitive inhibitor of mTOR, exhibiting an IC50 value of 0.8 nM. It is ~1,000-fold selective for mTOR over all PI3K isoforms and exhibits no activity against a panel of 260 kinases at concentrations up to 10 μM. AZD 8055 inhibits proliferation of A549 and H838 cells with IC50 values of 53 and 20 nM, respectively. It inhibits growth of a variety of human tumor xenografts by at least 65% in mice at daily oral doses of 20 mg/kg.Related product price
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