AZD-8055 manufacturers and suppliers in india

AZD-8055

Properties

Melting point:: 204 - 207°C

Boiling point:: 694.3±65.0 °C(Predicted)

Density: 1.248

storage temp.: -20°C

solubility: Soluble in DMSO (up to 30 mg/ml)

form: Yellow powder.

pka: 14.20±0.10(Predicted)

color: Yellow

Stability:: Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months.

Safety Information

Symbol(GHS): GHS07

Signal word: Warning

Hazard statements: H335-H319-H315

Precautionary statements: P264-P280-P302+P352-P321-P332+P313-P362-P264-P280-P305+P351+P338-P337+P313P

Safety Statements: 24/25

HS Code: 29335990

Use

A potent, selective, and orally bioavailable ATP-competitive mTOR kinase inhibitor with an IC50 of 0.8 nM. It inhibits the phosphorylation of mTORC1 substrates p70S6K and 4E-BP1 as well as phosphoryla tion of the mTORC2 substrate AKT and downstream proteins. The rapamycin-resistant T37/46 phosphorylation sites on 4E-BP1 were fully inhibited by AZD8055, resulting in significant inhibition of cap-dep endent translation. In vitro, AZD8055 potently inhibits proliferation and induces autophagy in H838 and A549 cells. In vivo, AZD8055 induces a dose-dependent pharmacodynamic effect on phosphorylated S 6 and phosphorylated AKT at plasma concentrations leading to tumor growth inhibition.