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ChemicalBook > Product Catalogue >Biochemical Engineering >Inhibitors >Cell Cycle >Aurora Kinase Inhibitors >ZM 447439

ZM 447439

ZM 447439 Structure
  • ₹15469.99
  • Product name: ZM 447439
  • CAS: 331771-20-1
  • MF: C29H31N5O4
  • MW: 513.59
  • EINECS:
  • MDL Number:MFCD08703125
  • Synonyms:N-[4-[[6-METHOXY-7-[3-(4-MORPHOLINYL)PROPOXY]-4-QUINAZOLINYL]AMINO]PHENYL]BENZAMIDE;ZM 447439;N-(4-((6-Methoxy-7-(3-Morpholinopropoxy)quinazolin-4-yl)aMino)phenyl)benzaMide;BenzaMide, N-[4-[[6-Methoxy-7-[3-(4-Morpholinyl)propoxy]-4-quinazolinyl]aMino]phenyl]-;ZM-447439;ZM447439;ZM 447439, >=98%;Aurora Kinase Inhibitor VI, ZM447439 - CAS 331771-20-1 - Calbiochem;CS-77
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Brand

  • Sigma-Aldrich
  • Sigma-Aldrich(India)

Package

  • 5MG
  • ManufacturerSigma-Aldrich
  • Product number189410
  • Product descriptionAurora Kinase Inhibitor VI, ZM447439 - CAS 331771-20-1 - Calbiochem The Aurora Kinase Inhibitor VI, ZM447439, also referenced under CAS 331771-20-1, controls the biological activity of Aurora Kinase. This small molecule/inhibitor is primarily used for Phosphorylation
  • Packaging5MG
  • Price₹15469.99
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product number189410
  • Product descriptionAurora Kinase Inhibitor VI, ZM447439 - CAS 331771-20-1 - Calbiochem The Aurora Kinase Inhibitor VI, ZM447439, also referenced under CAS 331771-20-1, controls the biological activity of Aurora Kinase. This small molecul
  • Packaging5MG
  • Price₹15469.99
  • Updated2022-06-14
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
Sigma-Aldrich 189410 Aurora Kinase Inhibitor VI, ZM447439 - CAS 331771-20-1 - Calbiochem The Aurora Kinase Inhibitor VI, ZM447439, also referenced under CAS 331771-20-1, controls the biological activity of Aurora Kinase. This small molecule/inhibitor is primarily used for Phosphorylation 5MG ₹15469.99 2022-06-14 Buy
Sigma-Aldrich(India) 189410 Aurora Kinase Inhibitor VI, ZM447439 - CAS 331771-20-1 - Calbiochem The Aurora Kinase Inhibitor VI, ZM447439, also referenced under CAS 331771-20-1, controls the biological activity of Aurora Kinase. This small molecul 5MG ₹15469.99 2022-06-14 Buy

Properties

Melting point :117-120°C
Boiling point :639.7±55.0 °C(Predicted)
Density :1.282±0.06 g/cm3(Predicted)
storage temp. :Desiccate at RT
solubility :Soluble in DMSO (up to 50 mg/ml) or in Ethanol (up to 25 mg/ml).
form :White solid
pka :13.01±0.70(Predicted)
color :White
Stability :Stable for 1 year from date of purchase? as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
Precautionary statements:
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352 IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P332+P313 IF SKIN irritation occurs: Get medical advice/attention.
P337+P313 IF eye irritation persists: Get medical advice/attention.

Description

ZM 447439 is a selective and ATP-competitive inhibitor for Aurora A and Aurora B with IC50 of 110 nM and 130 nM, respectively. It is more than 8-fold selective for Aurora A/B than MEK1, Src, Lck and has little effect against CDK1/2/4, Plk1, Chk1, etc.

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