ZM 39923 HCl
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- ₹0
- Product name: ZM 39923 HCl
- CAS: 1021868-92-7
- MF: C23H26ClNO
- MW: 367.91164
- EINECS:
- MDL Number:
- Synonyms:1-Propanone, 3-[(1-methylethyl)(phenylmethyl)amino]-1-(2-naphthalenyl)-, hydrochloride (1:1);3-[(1-Methylethyl)(phenylmethyl)amino]-1-(2-naphthalenyl)-1-propanone hydrochloride;N-benzyl-N-isopropyl-3-(2-naphthyl)but-3-en-1-amine,hydrochloride;ZM 39923 HCL 50MG;-1-(naphthalen-2-yl);3-(Benzyl(isopropyl);propan-1-one hydrochloride;ZM 39923 HCl, ≥98%
Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
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Properties
storage temp. :Inert atmosphere,Room Temperature
solubility :≥7.74 mg/mL in EtOH with gentle warming and ultrasonic; ≥9.2 mg/mL in DMSO
form :solid
color :White to off-white
Stability :Hygroscopic
solubility :≥7.74 mg/mL in EtOH with gentle warming and ultrasonic; ≥9.2 mg/mL in DMSO
form :solid
color :White to off-white
Stability :Hygroscopic
Safety Information
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Description
Janus kinases (JAKs) are non-receptor kinases that mediate signaling through cytokine receptors, often to members of the signal transducer and activator of transcription (Stat) family. ZM 39923 is an inhibitor of JAK3 (IC50 = 79 nM) that less potently inhibits epidermal growth factor receptor, JAK1, and cyclin-dependent kinase 4 (IC50s = 2.4, 40, and 10 μM, respectively). In the absence of the reducing agent dithiothreitol, ZM 39923 also inhibits human tissue transglutaminase 2 (TGM2) and the transglutaminase Factor XIIIa (IC50s= 10 and 25 nM, respectively). It breaks down in neutral buffer to form ZM 449829, which is also an inhibitor of JAK3, TGM2, and Factor XIIIa.Related product price
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