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ChemicalBook > Product Catalogue >Biochemical Engineering >Inhibitors >Proteases >Serine Protease Inhibitors >Nafamostat mesylate

Nafamostat mesylate

Nafamostat mesylate Structure
  • ₹4500 - ₹62081.38
  • Product name: Nafamostat mesylate
  • CAS: 82956-11-4
  • MF: C21H25N5O8S2
  • MW: 539.58
  • EINECS:692-168-2
  • MDL Number:MFCD00941430
  • Synonyms:4-((aminoiminomethyl)amino)-benzoicaci6-(aminoiminomethyl)-2-naphthalenyl ;6-carbaMiMidoylnaphthalen-2-yl 4-guanidinobenzoate diMethanesulfonate;[amino-[6-[[4-(diaminomethyleneazaniumyl)phenyl]-oxomethoxy]-2-naphthyl]methylene]ammonium;[amino-[6-[4-(diaminomethyleneazaniumyl)benzoyl]oxy-2-naphthyl]methylene]ammonium;[amino-[6-[4-(diaminomethylideneazaniumyl)benzoyl]oxynaphthalen-2-yl]methylidene]azanium;[amino-[6-[4-(diaminomethylideneazaniumyl)phenyl]carbonyloxynaphthalen-2-yl]methylidene]azanium;Nafamostat mesylate, >=98%;5-methyl-1-{6-[(7-oxo-7h-furo[3,2-g]chromen-9-yl)oxy]hexyl}pyrimidine-2,4(1h,3h)-dione
4 prices
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Brand

  • TCI Chemicals (India)
  • Sigma-Aldrich(India)

Package

  • 10MG
  • 20MG
  • 50MG
  • 100MG
  • ManufacturerTCI Chemicals (India)
  • Product numberN0959
  • Product descriptionNafamostat Mesylate
  • Packaging20MG
  • Price₹4500
  • Updated2022-05-26
  • Buy
  • ManufacturerTCI Chemicals (India)
  • Product numberN0959
  • Product descriptionNafamostat Mesylate
  • Packaging100MG
  • Price₹8700
  • Updated2022-05-26
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberN0289
  • Product descriptionNafamostat mesylate ≥98% (HPLC)
  • Packaging10MG
  • Price₹14473.03
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberN0289
  • Product descriptionNafamostat mesylate ≥98% (HPLC)
  • Packaging50MG
  • Price₹62081.38
  • Updated2022-06-14
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
TCI Chemicals (India) N0959 Nafamostat Mesylate 20MG ₹4500 2022-05-26 Buy
TCI Chemicals (India) N0959 Nafamostat Mesylate 100MG ₹8700 2022-05-26 Buy
Sigma-Aldrich(India) N0289 Nafamostat mesylate ≥98% (HPLC) 10MG ₹14473.03 2022-06-14 Buy
Sigma-Aldrich(India) N0289 Nafamostat mesylate ≥98% (HPLC) 50MG ₹62081.38 2022-06-14 Buy

Properties

Melting point :259-261°C
storage temp. :Sealed in dry,Room Temperature
solubility :Soluble in Water (up to 25 mg/ml).
form :powder
color :white to beige
Merck :14,6350
Stability :Stable for 2 years from date of purchase as supplied. Solutions in distilled water may be stored at 4°C for up to 1 month, or at -80°C for up to 6 months.
InChIKey :SRXKIZXIRHMPFW-UHFFFAOYSA-N
SMILES :CS(O)(=O)=O.CS(O)(=O)=O.C(OC1=CC=C2C(=C1)C=CC(C(=N)N)=C2)(=O)C1=CC=C(NC(N)=N)C=C1
CAS DataBase Reference :82956-11-4(CAS DataBase Reference)

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
Precautionary statements:
P201 Obtain special instructions before use.
P202 Do not handle until all safety precautions have been read and understood.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P308+P313 IF exposed or concerned: Get medical advice/attention.
P405 Store locked up.
P501 Dispose of contents/container to..…

Description

Nafamostat is a serine protease inhibitor that is capable of inhibiting trypsin (a digestive system protease; Ki = 15 nM), tryptase (a mast cell protease; Ki = 95.3 pM), and additional proteases in the coagulation cascade including thrombin (Ki = 0.84 μM). In a mouse model of allergic asthma, a dose of 300 mg/kg nafamostat mesylate has been shown to inhibit serine proteolytic activity, to decrease circulating levels of eosinophils and lymphocytes in bronchoalveolar lavage fluid, and to reduce interleukin-13 and eotaxin production associated with antigen-induced airway eosinophilia and goblet cell hyperplasia.

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