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ChemicalBook > Product Catalogue >Biochemical Engineering >Inhibitors >protein tyrosine kinase >ZM 306416

ZM 306416

ZM 306416 Structure
  • ₹0
  • Product name: ZM 306416
  • CAS: 690206-97-4
  • MF: C16H13ClFN3O2
  • MW: 333.74
  • EINECS:
  • MDL Number:MFCD02683969
  • Synonyms:ZM 306416 HYDROCHLORIDE;4-[(4'-CHLORO-2'-FLUORO)PHENYLAMINO]-6,7-DIMETHOXYQUINAZOLINE HYDROCHLORIDE;4-QuinazolinaMine,N-(4-chloro-2-fluorophenyl)-6,7-diMethoxy-;ZM306416/ZM-306416;CB 676475;CB-676475;ZM 213689 DisodiuM Salt (MeropeneM iMpurity) (Mixture of double bond isoMers);N-(4-Chloro-2-fluorophenyl)-6,7-dimethoxy-4-quinazolinamine
Manufacturer Product number Product description Packaging Price Updated Buy

Properties

Melting point :>161°C (dec.)
Boiling point :434.1±45.0 °C(Predicted)
Density :1.389±0.06 g/cm3(Predicted)
storage temp. :Keep in dark place,Inert atmosphere,2-8°C
solubility :Methanol (Slightly), Water (Sparingly)
form :Off-white solid.
pka :5.49±0.30(Predicted)
color :Light Orange to Brown
Stability :Hygroscopic

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P271 Use only outdoors or in a well-ventilated area.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352 IF ON SKIN: wash with plenty of soap and water.
P304+P340 IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P312 Call a POISON CENTER or doctor/physician if you feel unwell.
P403+P233 Store in a well-ventilated place. Keep container tightly closed.

Description

ZM 306416 is an inhibitor of vascular endothelial growth factor (VEGF) receptor tyrosine kinase that antagonizes the activity of KDR and Flt VEGF receptors with IC50 values of 100 nM and 2 μM, respectively. It has also been reported to inhibit EGFR kinase with an IC50 value of < 10 nM, reducing proliferation of EGFR-dependent cancer cells.

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