Urea, N-[5-chloro-2-[2-[(2R)-4-[(4-fluorophenyl)Methyl]-2-Methyl-1-piperazinyl]-2-oxoethoxy]phenyl]-
![Urea, N-[5-chloro-2-[2-[(2R)-4-[(4-fluorophenyl)Methyl]-2-Methyl-1-piperazinyl]-2-oxoethoxy]phenyl]- Structure](/CAS/GIF/217645-70-0.gif)
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- ₹4000 - ₹84859.5
- Product name: Urea, N-[5-chloro-2-[2-[(2R)-4-[(4-fluorophenyl)Methyl]-2-Methyl-1-piperazinyl]-2-oxoethoxy]phenyl]-
- CAS: 217645-70-0
- MF: C21H24ClFN4O3
- MW: 434.89
- EINECS:
- MDL Number:MFCD09859709
- Synonyms:Urea, N-[5-chloro-2-[2-[(2R)-4-[(4-fluorophenyl)Methyl]-2-Methyl-1-piperazinyl]-2-oxoethoxy]phenyl]-;(5-Chloro-2-{2-[4-(4-fluoro-benzyl)-2-Methyl-piperazin-1-yl]-2-oxo-ethoxy}-phenyl)-urea;ZK811752 (BX471);(2R)-1-[[2-[(Aminocarbonyl)amino]-4-chlorophenoxy]acetyl]-4-[(4-fluorophenyl)methyl]-2-methylpiperazine ZK811752 (BX471);N-[5-chloro-2-[2-[(2R)-4-[(4-fluorophenyl)methyl]-2-methyl-1-piperazinyl]-2-oxoethoxy]phenyl]-urea;BX471(ZK-811752);Piperazine,1-[[2-[(aminocarbonyl)amino]-4-chlorophenoxy]acetyl]-4-[(4-fluorophenyl)methyl]-2-methyl-, (2R)-;(2R)-1-[[[4-Chloro-2-(ureido)phenoxy]methyl]carbonyl]-2-methyl-4-(4-fluorobenzyl)piperazine
4 prices
Selected condition：
Brand
- TCI Chemicals (India)
- Sigma-Aldrich(India)
Package
- 5MG
- 25MG
- ManufacturerTCI Chemicals (India)
- Product numberB6060
- Product descriptionBX 471
- Packaging5MG
- Price₹4000
- Updated2022-05-26
- Buy
- ManufacturerTCI Chemicals (India)
- Product numberB6060
- Product descriptionBX 471
- Packaging25MG
- Price₹13000
- Updated2022-05-26
- Buy
- ManufacturerSigma-Aldrich(India)
- Product numberSML0020
- Product descriptionBX471 ≥98% (HPLC)
- Packaging5MG
- Price₹21090
- Updated2022-06-14
- Buy
- ManufacturerSigma-Aldrich(India)
- Product numberSML0020
- Product descriptionBX471 ≥98% (HPLC)
- Packaging25MG
- Price₹84859.5
- Updated2022-06-14
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| TCI Chemicals (India) | B6060 | BX 471 | 5MG | ₹4000 | 2022-05-26 | Buy |
| TCI Chemicals (India) | B6060 | BX 471 | 25MG | ₹13000 | 2022-05-26 | Buy |
| Sigma-Aldrich(India) | SML0020 | BX471 ≥98% (HPLC) | 5MG | ₹21090 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | SML0020 | BX471 ≥98% (HPLC) | 25MG | ₹84859.5 | 2022-06-14 | Buy |
Properties
Boiling point :593.5±50.0 °C(Predicted)
Density :1.346±0.06 g/cm3(Predicted)
storage temp. :Inert atmosphere,2-8°C
solubility :DMSO: ≥25mg/mL
pka :13.66±0.70(Predicted)
form :White powder
color :white to tan
Density :1.346±0.06 g/cm3(Predicted)
storage temp. :Inert atmosphere,2-8°C
solubility :DMSO: ≥25mg/mL
pka :13.66±0.70(Predicted)
form :White powder
color :white to tan
Safety Information
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Description
The CC chemokine receptor-1 (CCR1), whose ligands include macrophage inflammatory protein-1α (MIP-1α), RANTES, and monocyte chemotactic protein-3 (MCP-3), has a central role in leukocyte trafficking and is highly expressed in certain autoimmune diseases. BX 471 is a nonpeptide CCR1 antagonist that has been shown to displace MIP-1α, RANTES, and MCP-3 with Ki values of 1, 2.8, and 5.5 nM, respectively. It demonstrates >10,000-fold selectivity for CCR1 over 28 additional G protein-coupled receptors, including related chemokine receptors. In a rat experimental allergic encephalomyelitis model of multiple sclerosis, BX 471 at 50 mg/kg was shown to significantly reduce the severity of the disease. BX 471 also decreases the inflammatory response during sepsis, blocks migration of monocytes isolated from rheumatoid arthritis patients, and prevents macrophage and T-cell recruitment in a mouse model of lupus nephritis.Suppliers and manufacturers
CLEARSYNTH LABS LTD.
TCI Chemicals (India) Pvt. Ltd.
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Wuhan Jingkang en Biomedical Technology Co., Ltd
