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AZD-7648

AZD-7648 Structure
  • ₹0
  • Product name: AZD-7648
  • CAS: 2230820-11-6
  • MF: C18H20N8O2
  • MW: 380.4
  • EINECS:-0
  • MDL Number:MFCD32062688
  • Synonyms:CPD2810;AZD-7648;AZD-7648;AZD 7648;AZD7648;7-Methyl-2-((7-methyl-[1,2,4]triazolo[1,5-a]pyridin-6-yl)amino)-9-(tetrahydro-2H-pyran-4-yl)-7H-purin-8(9H)-one;AZD7640;8H-Purin-8-one, 7,9-dihydro-7-methyl-2-[(7-methyl[1,2,4]triazolo[1,5-a]pyridin-6-yl)amino]-9-(tetrahydro-2H-pyran-4-yl)-;7-Methyl-2-((7-methyl-[1,2,4]triazolo[1,5-a]pyridin-6-yl)amino)-9-(tetrahydro-2H-pyran-4-yl)-7,9-dihydro-8H-purin-8-one;DNA-dependent protein kinase,inhibit,Apoptosis,AZD7648,A549,OAW42,PI3K,Inhibitor,Phosphoinositide 3-kinase,AZD-7648,Ataxia telangiectasia mutated,antitumor,ATM and RAD3 related,ATM/ATR,AZD 7648,DNA-PK
Manufacturer Product number Product description Packaging Price Updated Buy

Properties

Density :1.60±0.1 g/cm3(Predicted)
storage temp. :Store at -20°C
solubility :DMSO : 5 mg/mL (13.14 mM; ultrasonic and warming and heat to 80°C)
form :A crystalline solid
pka :3.53±0.20(Predicted)
color :Off-white to light yellow

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning GHS hazard pictograms P264, P270, P301+P312, P330, P501
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

AZD7648 is a potent and selective DNA-PK inhibitor that enhances radiation, chemotherapy and olaparib activity in non small cell lung cancer.