XE 991 dihydrochloride
- CAS No.
- 122955-13-9
- Chemical Name:
- XE 991 dihydrochloride
- Synonyms
- XE 991 HCl;XE991 HCl (LS190926);XE 991 (hydrochloride);10,10-bis(pyridin-4-ylmethyl)anthracen-9-one;10,10-bis(pyridin-4-ylmethyl)anthracen-9-one:dihydrochloride;10,10-Bis(pyridin-4-ylmethyl)anthracen-9(10H)-one dihydrochloride;XE991,inhibit,XE 991 dihydrochloride,KcsA,XE 991,XE-991,Inhibitor,Potassium Channel
- CBNumber:
- CB63146404
- Molecular Formula:
- C26H21ClN2O
- Molecular Weight:
- 412.92
- MOL File:
- 122955-13-9.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/7/2 8:55:14
XE 991 dihydrochloride Chemical Properties,Uses,Production
Description
The KCNQ potassium channels are neuronal modulators which combine with other KQT or KCNE channels to form heteromultimers. XE 991 is a blocker of KCNQ channels that potently inhibits KCNQ1 and 2 homomeric channels (IC50 = 0.75 and 0.71 μM, respectively) as well as KCNQ2+3 heteromultimers (IC50 = 0.6 μM). It much less effectively blocks eag, erg, and elk channels. The effectiveness of XE 991 against KCNQ channels depends on partners or accessory proteins. Through these actions, XE 991 enhances acetylcholine release from rat brain slices (EC50 = 490 nM) and shows good in vivo potency and duration of action, suggesting utility in Alzheimer’s disease therapeutics. While early studies focused on actions in the central nervous system, XE 991 can be used to explore the roles of KCNQ channels in neuronal regulation throughout the body.
Uses
XE 991 dihydrochloride is a potent & selective inhibitor of KCNQ voltage-gated K-channels.
XE 991 dihydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
XE 991 dihydrochloride Suppliers
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | China | 32760 | 60 | Inquiry |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | United States | 19892 | 58 | Inquiry |
| InvivoChem | +1-708-310-1919 +1-13798911105 | United States | 6393 | 58 | Inquiry |
| Hangzhou MolCore BioPharmatech Co.,Ltd. | +86-057181025280; +8617767106207 | China | 49739 | 58 | Inquiry |
| Aladdin Scientific | +1-+1(833)-552-7181 | United States | 57511 | 58 | Inquiry |
| Shanghai Aladdin Biochemical Technology Co.,Ltd. | +86-18521732826 | China | 48467 | 58 | Inquiry |
| Bide Pharmatech Ltd. | 400-1647117 15221909166 | China | 63720 | 58 | Inquiry |
| InvivoChem | 13549236410 | China | 6749 | 58 | Inquiry |
| Nanjing Tengyi Biotechnology Co., Ltd | 025-58851786 17714337195 | China | 5595 | 58 | Inquiry |
| Suzhou Zhixin Biotechnology Co., Ltd. | 0512-65118909 15162312715 | China | 2992 | 58 | Inquiry |