E3 ligase Ligand-Linker Conjugates 11
- CAS No.
- 1835705-61-7
- Chemical Name:
- E3 ligase Ligand-Linker Conjugates 11
- Synonyms
- (S,R,S)-AHPC-6-5-6-Cl;(S,R,S)-AHPC-(C3-PEG)2-C6-C;VHL Ligand-Linker Conjugates 11;E3 ligase Ligand-Linker Conjugates 11;(S,R,S)-AHPC-C6-PEG1-C3-PEG1-butyl chloride;L-Prolinamide, N-[6-[[5-[(6-chlorohexyl)oxy]pentyl]oxy]-1-oxohexyl]-3-methyl-L-valyl-4-hydroxy-N-[[4-(4-methyl-5-thiazolyl)phenyl]methyl]-, (4R)-
- CBNumber:
- CB63386464
- Molecular Formula:
- C39H61ClN4O6S
- Molecular Weight:
- 749.44
- MOL File:
- 1835705-61-7.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/7/2 8:55:14
SAFETY
Risk and Safety Statements
Symbol(GHS) | GHS07 |
---|---|
Signal word | Warning |
Hazard statements | H302-H315-H319-H335 |
Precautionary statements | P261-P280-P301+P312-P302+P352-P305+P351+P338 |
E3 ligase Ligand-Linker Conjugates 11 Chemical Properties,Uses,Production
Uses
Protein degrader builiding block (S,R,S)-AHPC-C6-PEG1-C3-PEG1-butyl Chloride enables the synthesis of molecules for targeted protein degradation and PROTAC (proteolysis-targeting chimeras) technology. This conjugate contains a von Hippel–Lindau (VHL)-recruiting ligand, a linker with both hydrophobic and hydrophilic moieties, and a pendant chloroalkane for reactivity with a nucleophilic group on a target ligand. Because even slight alterations in ligands and crosslinkers can affect ternary complex formation between the target, E3 ligase, and PROTAC, many analogs are prepared to screen for optimal target degradation. When used with other protein degrader building blocks with a pendant chloro group, parallel synthesis can be used to more quickly generate PROTAC libraries that feature variation in crosslinker length, composition, and E3 ligase ligand.
E3 ligase Ligand-Linker Conjugates 11 Preparation Products And Raw materials
Raw materials
Preparation Products
E3 ligase Ligand-Linker Conjugates 11 Suppliers
Supplier | Tel | Country | ProdList | Advantage | Inquiry |
---|---|---|---|---|---|
TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | United States | 19892 | 58 | Inquiry |
Xian confluore Biological Technology Co., Ltd. | +86-15680926068 +86-15680926068 | China | 2996 | 58 | Inquiry |
Xi'an Confluore Biological Technology Co., Ltd. | +86-156-80926068 +86-15680926068 | China | 4824 | 58 | Inquiry |
TargetMol Chemicals Inc. | 15002134094 | China | 28091 | 58 | Inquiry |
Henan Alpha Chemical Co., Ltd. | 0371-55013243 15324716602 | China | 10010 | 58 | Inquiry |
Shanghai Haohong Pharmaceutical Co., Ltd. | 400-8210725 4008210725 | China | 40035 | 58 | Inquiry |
Sigma-Aldrich | 021-61415566 800-8193336 | China | 51471 | 80 | Inquiry |
ChemShuttle. Inc. | +1 510.999.8905 | United States | 6695 | 58 | Inquiry |
ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 | China | 11289 | 58 | Inquiry |
Changzhou Bojia Biomedical Technology Co., Ltd. | 2122619822 | China | 18488 | 58 | Inquiry |