E3 ligase Ligand-Linker Conjugates 13
- CAS No.
- 2010159-45-0
- Chemical Name:
- E3 ligase Ligand-Linker Conjugates 13
- Synonyms
- VH032-PEG2-N3;S)-AHPC-PEG2-N3;(S,R,S)-AHPC-PEG2-azide;VHL Ligand-Linker Conjugates 6;E3 ligase Ligand-Linker Conjugates 13;E3 Ligase Ligand-Linker Conjugates,(S,R,S)AHPCPEG2N3,Inhibitor,inhibit,(S,R,S)-AHPC-PEG-2-N3,(S,R,S) AHPC PEG2 N3;(2S,4R)-1-((S)-2-(2-(2-(2-azidoethoxy)ethoxy)acetamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide;(2S,4R)-1-((S)-2-(2-(2-(2-Azidoethoxy)ethoxy)acetamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide, Crosslinker?E3 ligase ligand conjugate, Protein degrader building block for PROTAC? research, Template for synthesis of targeted protein degrader, VH032 conjugate
- CBNumber:
- CB93386465
- Molecular Formula:
- C28H39N7O6S
- Molecular Weight:
- 601.72
- MOL File:
- 2010159-45-0.mol
- Modify Date:
- 2024/7/2 8:55:42
E3 ligase Ligand-Linker Conjugates 13 Chemical Properties,Uses,Production
Uses
Protein degrader builiding block (S,R,S)-AHPC-PEG2-azide enables the synthesis of molecules for targeted protein degradation and PROTAC (proteolysis-targeting chimeras) technology. This conjugate contains a von Hippel-Lindau (VHL)-recruiting ligand and a PEGylated crosslinker with pendant azide for click chemistry with a target ligand. Because even slight alterations in ligands and crosslinkers can affect ternary complex formation between the target, E3 ligase, and PROTAC, many analogs are prepared to screen for optimal target degradation. When used with other protein degrader building blocks with a pendant azide group, parallel synthesis can be used to more quickly generate PROTAC libraries that feature variation in crosslinker length, composition, and E3 ligase ligand.
E3 ligase Ligand-Linker Conjugates 13 Preparation Products And Raw materials
Raw materials
Preparation Products
E3 ligase Ligand-Linker Conjugates 13 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
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| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | United States | 19892 | 58 | Inquiry |
| Xian confluore Biological Technology Co., Ltd. | +86-15680926068 +86-15680926068 | China | 2996 | 58 | Inquiry |
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| Henan Alpha Chemical Co., Ltd. | 0371-55013243 15324716602 | China | 10010 | 58 | Inquiry |
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| Shanghai Haohong Pharmaceutical Co., Ltd. | 400-8210725 4008210725 | China | 40035 | 58 | Inquiry |
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