SJA6017
- CAS No.
- 190274-53-4
- Chemical Name:
- SJA6017
- Synonyms
- SJA6017;Calpain-In-4;Calpain Inhibitor 4;CALPAIN INHIBITOR VI;4-FLUORO-BENZENESULFONYL-VAL-L-LEUCINAL;4-FLUORO-BENZENESULFONYL-VAL-LEU-ALDEHYDE;N-(4-FLUOROPHENYLSULFONYL)-L-VALYL-L-LEUCINAL;SJA6017, 4-Fluoro-benzenesulfonyl-Val-L-leucinal;Calpain Inhibitor VI 4-Fluoro-benzenesulfonyl-Val-Leu-aldehyde;Butanamide, 2-[[(4-fluorophenyl)sulfonyl]amino]-N-[(1S)-1-formyl-3-methylbutyl]-3-methyl-, (2S)-
- CBNumber:
- CB6427018
- Molecular Formula:
- C17H25FN2O4S
- Molecular Weight:
- 372.45
- MOL File:
- 190274-53-4.mol
- MSDS File:
- SDS
- Modify Date:
- 2023/5/21 10:59:17
SJA6017 Chemical Properties,Uses,Production
Description
Calpain inhibitor VI is an inhibitor of the calcium-dependent cysteine proteases μ-calpain (calpain-1; IC50 = 7.5 nM) and m-calpain (calpain-2; IC50 = 78 nM). It also inhibits cathepsins B and L (IC50s = 15 and 1.6 nM, respectively). It is selective for these calpains and cathepsins over other cysteine and serine proteases, factor VIIa, factor Xa, trypsin, chymotrypsin, and proteasome. In an in vitro porcine model of cataract, calpain inhibitor VI decreases the degree of cataract by 40% when used at a concentration of 0.8 μM. It also prevents cataract formation induced by selenite in rats when administered at a dose of 100 mg/kg for 4 days. Calpain inhibitor VI improves functional outcome and reduces apoptotic cell death in a rat model of spinal cord injury.
SJA6017 Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| Alpha Biopharmaceuticals Co., Ltd | +86-15542445688 | China | 888 | 58 | Inquiry |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | United States | 19892 | 58 | Inquiry |
| Nextpeptide Inc | +86-0571-81612335 +8613336028439 | China | 19915 | 58 | Inquiry |
| Nanjing TGpeptide | +86-13347807150 +86-13347807150 | China | 3279 | 58 | Inquiry |
| Aladdin Scientific | +1-+1(833)-552-7181 | United States | 52927 | 58 | Inquiry |
| Nantong Hanfang Biotechnology Co. , Ltd. | 18616537568 | China | 30968 | 58 | Inquiry |
| Chengdu Youngshe Chemical Co., Ltd. | +86-17380623303 +86-17380623303 | China | 4887 | 58 | Inquiry |
| TargetMol Chemicals Inc. | 4008200310 | China | 23962 | 58 | Inquiry |
| Cayman Chemical Company | (800) 364-9897 | United States | 6618 | 81 | Inquiry |
| Shanghai Yifei Biotechnology Co. , Ltd. | 021-65675885 18964387627 | China | 8739 | 58 | Inquiry |