ASTRESSIN

CAS No.: 170809-51-5

Chemical Name:: ASTRESSIN

Synonyms: ASTRESSIN;Astressin TFA;ASTRESSIN (HUMAN, RAT);Astressin >=90% (HPLC);M.W. 3563.24 C161H269N49O42;ASTRESSIN TRIFLUOROACETATE SALT;[D-PHE12, NLE21,38, GLU30, LYS33]-CRF (12-41) (HUMAN, RAT);[D-PHE12, NLE21,38, GLU30, LYS33]-CRF (12-41), CYCLIC LACTAM, HUMAN, RAT;[D-PHE12,NLE21,38,GLU30,LYS33]-CORTICOTROPIN RELEASING FACTOR FRAGMENT 12-41;(D-PHE12,NLE21,38,GLU30,LYS33)-CRF (12-41) (HUMAN, RAT) TRIFLUOROACETATE SALT

CBNumber:: CB6437677

Molecular Formula:: C161H269N49O42

Molecular Weight:: 3563.16

MOL File:: 170809-51-5.mol

Modify Date:: 2024/7/2 8:55:14

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ASTRESSIN Properties

Density	1.43±0.1 g/cm3(Predicted)
storage temp.	−20°C
form	Powder
color	White to off-white
Water Solubility	Soluble to 1 mg/ml in 10% Acetic acid / water
Sequence	H-D-Phe-His-Leu-Leu-Arg-Glu-Val-Leu-Glu-Nle-Ala-Arg-Ala-Glu-Gln-Leu-Ala-Gln-Glu-Ala-His-Lys-Asn-Arg-Lys-Leu-Nle-Glu-Ile-Ile-NH2

SAFETY

Risk and Safety Statements

WGK Germany	3

ASTRESSIN price More Price(1)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich(India)	A4933	Astressin ≥90% (HPLC)	170809-51-5	0.5MG	₹55748.75	2022-06-14	Buy

Product number	Packaging	Price	Buy
A4933	0.5MG	₹55748.75	Buy

ASTRESSIN Chemical Properties,Uses,Production

Uses

Astressin has been used as a CRF-receptor antagonist to study its effects on the decrease in the Schaffer collateral-CA1 field potential induced by hypoxia/hypoglycemia (ischemia) in rat hippocampal slices.

Definition

ChEBI: A 30-membered homodetic cyclic peptide comprising the sequence D-Phe-His-Leu-Leu-Arg-Glu-Val-Leu-Glu-Nle-Ala-Arg-Ala-Glu-Gln-Leu-Ala-Gln-Glu-Ala-His-Lys-Asn-Arg-Lys-Leu-Nle-Glu-Ile-Ile-NH2 cyclised by an amide bridge, ormed by condensation of the side-chain carboxy group of the Glu residue at position 19 and the side-chain amino group of the Lys residue at position 22.

Enzyme inhibitor

This novel CRF antagonist (MW = 3663.20 g/mol; CAS 170809-51-5; Sequence: D-Phe-His-Leu-Leu-Arg-Glu-Val-Leu-Glu-Nle-Ala-Arg-Ala- Glu-Gln-Ala-Gln-cyclo-(g-Glu-Ala-His-e-Lys)Asn-Arg-Leu-Leu-Mle-Glu- Ile-Ile-NH2; Solubility: 1 mg/mL in Acetic acid/water (10% vol/vol); Alternate Name: [D-Phe 12 , Nle 21,38 , Glu30 , Lys 33 ]-CRF) targets human Corticotropin-Releasing hormone (CRH) Receptor subtypes CRF2α (Ki = 1.5 nM) and CRF2β (Ki = 1 nM), with a comparable value (2 nM) for CRF1. (See also Antisauvagine-30; K41448) These type-2 GPCRs reside in plasma membranes of hormone-sensitive cells and bind CRH, a peptide hormone and neurotransmitter involved in stress responses. Astressin is a structurally constrained and competitive antagonists of corticotropin- releasing factor. Astressin is neuroprotective in the hippocampus when administered after a seizure. Peripheral injection of astressin blocks peripheral CRF- and abdominal surgery-induced delayed gastric emptying in rats. A related antagonist is Astressin 2B (FW = 4041.69 g/mol; CAS 681260-70-8; Sequence: Ac-Asp-Leu-Ser-D-Phe-His-a-methyl-Leu-Leu- Arg-Lys-Nle-Ile-Glu-Ile-Glu-Lys-Gln-Glu-Lys-Glu-Lys-Gln-Gln-Ala- cyclo-(g-Glu-Ala-Asn-e-Lys)Leu-Leu-Leu-Asp-a-methyl-Leu-Ile-NH2). Astressin 2B is a potent and selective antagonist of CRF2 (IC50 = 1.3 nM) and CRF1 (IC50 > 500 nM).

ASTRESSIN Preparation Products And Raw materials

Raw materials

Preparation Products

ASTRESSIN Suppliers

Global( 97)Suppliers

Supplier	Tel	Country	ProdList	Advantage	Inquiry
Alpha Biopharmaceuticals Co., Ltd	+86-15542445688	China	888	58	Inquiry
Shenzhen Nexconn Pharmatechs Ltd	+86-755-89396905 +86-15013857715	China	10312	58	Inquiry
career henan chemical co	+86-0371-86658258 +8613203830695	China	29826	58	Inquiry
Fuxin Pharmaceutical	+86-021-021-50872116 +8613122107989	China	10297	58	Inquiry
Hebei Yanxi Chemical Co., Ltd.	+86-17531190177; +8617531190177	China	5873	58	Inquiry
BOC Sciences	16314854226; +16314854226	United States	19743	58	Inquiry
Zhejiang J&C Biological Technology Co.,Limited	+1-2135480471 +1-2135480471	China	10522	58	Inquiry
Nextpeptide Inc	+86-0571-81612335 +8613336028439	China	19915	58	Inquiry
Chengdu Youngshe Chemical Co., Ltd.	+8618108235634	China	2345	58	Inquiry
Wuhan senwayer century chemical Co.,Ltd	+undefined-27-86652399 +undefined13627115097	China	892	58	Inquiry

Supplier	Advantage
Alpha Biopharmaceuticals Co., Ltd	58
Shenzhen Nexconn Pharmatechs Ltd	58
career henan chemical co	58
Fuxin Pharmaceutical	58
Hebei Yanxi Chemical Co., Ltd.	58
BOC Sciences	58
Zhejiang J&C Biological Technology Co.,Limited	58
Nextpeptide Inc	58
Chengdu Youngshe Chemical Co., Ltd.	58
Wuhan senwayer century chemical Co.,Ltd	58

170809-51-5(ASTRESSIN)Related Search:

LCAT ASTRESSIN, [125I]- ASTRESSIN2B TRIFLUOROACETATE SALT astressin B ASTRESSIN2B

4,9-dioxo-5,10-diazatetradecane ASTRESSIN

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H-D-Phe-His-Leu-Leu-Arg-Glu-Val-Leu-Glu-Nle-Ala-Arg-Ala-Glu-Gln-Leu-Ala-Gln-cyclo(-Glu-Ala-His-Lys)-Asn-Arg-Lys-Leu-Nle-Glu-Ile-Ile-NH2 M.W. 3563.24 C161H269N49O42 DPHE-HIS-LEU-LEU-ARG-GLU-VAL-LEU-GLU-NLE-ALA-ARG-ALA-GLU-GLN-LEU-ALA-GLN-GLU-ALA-HIS-LYS-ASN-ARG-LYS-LEU-NLE-GLU-ILE-ILE-NH2 D-Phe-His-Leu-Leu-Arg-Glu-Val-Leu-Glu-Nle-Ala-Arg-Ala-Glu-Gln-Leu-Ala-Gln-Glu-Ala-His-Lys-Asn-Arg-Lys-Leu-Nle-Glu-Ile-Ile-NH2 (LactaM bridge Glu30-Lys33) H-D-PHE-HIS-LEU-LEU-ARG-GLU-VAL-LEU-GLU-NLE-ALA-ARG-ALA-GLU-GLN-LEU-ALA-GLN-CYCLO(-GAMMA-GLU-ALA-HIS-EPSILON-LYS)-ASN-ARG-LYS-LEU-NLE-GLU-ILE-ILE-NH2 [D-PHE12, NLE21,38, GLU30, LYS33]-CORTICOTROPIN RELEASING FACTOR (12-41) (HUMAN, RAT) [D-PHE12,NLE21,38,GLU30,LYS33]-CORTICOTROPIN RELEASING FACTOR FRAGMENT 12-41 [D-PHE12, NLE21,38, GLU30, LYS33]-CRF (12-41), CYCLIC LACTAM, HUMAN, RAT [D-PHE12, NLE21,38, GLU30, LYS33]-CRF (12-41) (HUMAN, RAT) (D-PHE12,NLE21,38,GLU30,LYS33)-CRF (12-41)(HUMAN, RAT) (CYCLIZED BETWEEN GAMMA-GLU30 ANDEPSILON-LYS33) (D-PHE12,NLE21,38,GLU30,LYS33)-CRF (12-41) (HUMAN, RAT) TRIFLUOROACETATE SALT D-PHE-HIS-LEU-LEU-ARG-GLU-VAL-LEU-GLU-NLE-ALA-ARG-ALA-GLU-GLN-LEU-ALA-GLN-GLU-ALA-HIS-LYS-ASN-ARG-LYS-LEU-NLE-GLU-ILE-ILE-NH2 ASTRESSIN ASTRESSIN (HUMAN, RAT) ASTRESSIN TRIFLUOROACETATE SALT Astressin trifluoroacetate salt H-D-Phe-His-Leu-Leu-Arg-Glu-Val-Leu-Glu-Nle-Ala-Arg-Ala-Glu-Gln-Leu-Ala-Gln-cyclo(-Glu-Ala-His-Lys)-Asn-Arg-Lys-Leu-Nle-Glu-Ile-Ile-NH2 trifluoroacetate salt L-Isoleucinamide, D-phenylalanyl-L-histidyl-L-leucyl-L-leucyl-L-arginyl-L-α-glutamyl-L-valyl-L-leucyl-L-α-glutamyl-L-norleucyl-L-alanyl-L-arginyl-L-alanyl-L-α-glutamyl-L-glutaminyl-L-leucyl-L-alanyl-L-glutaminyl-L-α-glutamyl-L-alanyl-L-histidyl-L-lysyl-L-asparaginyl-L-arginyl-L-lysyl-L-leucyl-L-norl... Astressin >=90% (HPLC) L-Isoleucinamide,D-phenylalanyl-L-histidyl-L-leucyl-L-leucyl-L-arginyl-L-a-glutamyl-L-valyl-L-leucyl-L-a-glutamyl-L-norleucyl-L-alanyl-L-arginyl-L-alanyl-L-a-glutamyl-L-glutaminyl-L-leucyl-L-alanyl-L- Astressin TFA 170809-51-5 C161H269N49O42 CRF Peptides Releasing Factors Biochemicals and Reagents Amino Acids and Peptides BioChemical CRF receptor and related