Zinc pyrithione
- CAS No.
- 13463-41-7
- Chemical Name:
- Zinc pyrithione
- Synonyms
- ZPT;Pyrithione zinc;ZNPT;Bis[[(pyridine 1-oxide)-2-yl]thio] zinc salt;zincpt;OM-1563;vancidep;vancide zp;ZPT(power);zincpyrion
- CBNumber:
- CB6456070
- Molecular Formula:
- C10H8N2O2S2Zn
- Molecular Weight:
- 317.7
- MOL File:
- 13463-41-7.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/8/2 16:47:38
| Melting point | approximate 240℃ |
|---|---|
| Density | 1.782 g/cm3(Temp: 25 °C) |
| vapor pressure | 0Pa at 25℃ |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | almost transparency in Pyridine |
| form | Powder |
| color | White to Orange to Green |
| Odor | Mild Characteristic |
| Water Solubility | Insoluble (<0.1 g/100 mL at 21 ºC) |
| Merck | 14,7994 |
| InChI | InChI=1S/2C5H5NOS.Zn/c2*7-6-4-2-1-3-5(6)8;/h2*1-4,8H;/q;;+2/p-2 |
| InChIKey | OTPSWLRZXRHDNX-UHFFFAOYSA-L |
| SMILES | C1(C=CC=C[N+]=1[O-])S[Zn]SC1C=CC=C[N+]=1[O-] |
| LogP | 0.9 at 25℃ and pH7.5-7.7 |
| Surface tension | 73mN/m at 7.22mg/L and 20℃ |
| CAS DataBase Reference | 13463-41-7(CAS DataBase Reference) |
| EPA Substance Registry System | Zinc pyrithione (13463-41-7) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |     GHS05,GHS06,GHS08,GHS09 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H301-H318-H330-H360D-H372-H410 | |||||||||
| Precautionary statements | P202-P260-P273-P280-P304+P340+P310-P305+P351+P338 | |||||||||
| Hazard Codes | T+,N,T | |||||||||
| Risk Statements | 24/25-26-37/38-41-50/53-23-22 | |||||||||
| Safety Statements | 26-28-36/37/39-45-61-60-39 | |||||||||
| RIDADR | UN 2811 6.1/PG 2 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | ZH0950000 | |||||||||
| HazardClass | 6.1(b) | |||||||||
| PackingGroup | III | |||||||||
| HS Code | 29333990 | |||||||||
| Toxicity | LD50 oral in rat: 177mg/kg | |||||||||
| NFPA 704 |
|
Zinc pyrithione price More Price(5)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | H6377 | 1-Hydroxypyridine-2-thione zinc salt ≥95% | 13463-41-7 | 10G | ₹8930.63 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | H6377 | 1-Hydroxypyridine-2-thione zinc salt ≥95% | 13463-41-7 | 100G | ₹27603.75 | 2022-06-14 | Buy |
| TCI Chemicals (India) | M0633 | 2-Mercaptopyridine N-Oxide Zinc Salt | 13463-41-7 | 25G | ₹7600 | 2022-05-26 | Buy |
| TCI Chemicals (India) | M0633 | 2-Mercaptopyridine N-Oxide Zinc Salt | 13463-41-7 | 100G | ₹8000 | 2022-05-26 | Buy |
| TCI Chemicals (India) | M0633 | 2-Mercaptopyridine N-Oxide Zinc Salt | 13463-41-7 | 500G | ₹13700 | 2022-05-26 | Buy |
Zinc pyrithione Chemical Properties,Uses,Production
Description
Zinc pyrithione is a coordination complex of zinc and pyrithione that has antimicrobial and anticancer activities. It is active against the bacteria E. coli, S. aureus, K. pneumoniae, A. baumannii, P. aeruginosa, E. faecium, E. faecalis, and E. cloacae (MICs = 1-4 μg/ml) and the fungus P. ovale when used at concentrations ranging from 0.01 to 10 μg/ml. Zinc pyrithione reduces tumor growth in an SCC-4 mouse xenograft model when administered at a dose of 1 mg/kg per week for six weeks. Formulations containing zinc pyrithione have been used in the treatment of dandruff.
Chemical Properties
Beige granules
Uses
Zinc pyrithione is directly cytotoxic and has antimicrobial effects. Zinc pyrithione is found in many shampoos (DHS-Zinc, Head and Shoulders) and should be applied for 5 minutes daily for 2 weeks.
Zinc pyrithione is the active ingredient in several shampoos used to control dandruff and seborrheic dermatitis and is also effective in the therapy of tinea versicolor. It remains unclear whether the beneficial effects are caused by an antiproliferative or antimicrobial effect or both. It is substantive to the hair, allowing continued therapeutic effect after washing.
Indications
Zinc pyrithione is the active ingredient in several shampoos used to control dandruff and seborrheic dermatitis and is also effective in the therapy of tinea versicolor. It remains unclear whether the beneficial effects are caused by an antiproliferative or antimicrobial effect or both. It is substantive to the hair, allowing continued therapeutic effect after washing.
General Description
Fine beige granules.
Air & Water Reactions
Insoluble in water.
Reactivity Profile
Organometallics, such as Zinc pyrithione, are reactive with many other groups. Incompatible with acids and bases. Organometallics are good reducing agents and therefore incompatible with oxidizing agents. Often reactive with water to generate toxic or flammable gases.
Fire Hazard
Flash point data for Zinc pyrithione are not available, but Zinc pyrithione is probably combustible.
Contact allergens
Zinc pyrithione is widely used in antidandruff shampoos and is a classic allergen. Concomitant reactions are expected to both zinc and sodium pyrithione.
Safety Profile
Poison by ingestion, skin contact, intraperitoneal, and intravenous routes. Moderately toxic by subcutaneous route. An experimental teratogen. Experimental reproductive effects. An eye irritant. When heated to decomposition it emits very toxic fumes of NOx, SOx, and ZnO. Used as an anti- dandruff agent in shampoos. See also ZINC COMPOUNDS and SULFIDES.
Synthesis
1000 g of sodium pyrithione, 20% aqueous solution (1.34 mmol of sodium pyrithione) was added to a 2L reactor equipped with a mechanical agitator and warmed to 70 °C with stirring. To the solution was added 190 g of 50 % zinc chloride (0.7 mmol of zinc chloride) over 10 minutes. After the completion of the addition, the solution was stirred at 70 °C for one hour, dehydrated and then washed with 500 g of distilled water. The solid thus obtained was dried with a heated-air drier at 70 °C to have a moisture content of less than 0.5 % and ground with a hammer mill to obtain a find powder of zinc pyrithione. The zinc pyrithione thus obtained was 212 g with a yield of 99.5 %.
Zinc pyrithione Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| Salicylates and Chemicals Pvt. Ltd. | +91-8879630551 +91-8898005838 | Maharashtra, India | 61 | 58 | Inquiry |
| Jubilant Ingrevia | +91-1204361000 +91-1204361000 | Uttar Pradesh, India | 142 | 58 | Inquiry |
| Emmennar Pharma Pvt Ltd | +91-7680064455 +91-9966766666 | Telangana, India | 31 | 58 | Inquiry |
| Speciality Organics Pvt Ltd | 9959551278 | AndhraPradesh, India | 19 | 58 | Inquiry |
| Kumar Organic Products Ltd | +91-9845286706 +91-8041425832 | Karnataka, India | 26 | 58 | Inquiry |
| Malladi Specialties Ltd. | +91 (40) 2720-4991 | New Delhi, India | 20 | 50 | Inquiry |
| Prakash Chemicals International Private Limited | 91-265-6126197 | New Delhi, India | 204 | 58 | Inquiry |
| Jubilant Infrastructure Limited | +91 120 4361000 | Uttar Pradesh, India | 286 | 58 | Inquiry |
| Central Drug House(P) Ltd. | 91-11-49404040 | New Delhi, India | 6160 | 58 | Inquiry |
| Triveni chemicals | 08048762458 | New Delhi, India | 6093 | 58 | Inquiry |
Related articles
- Zinc Pyrithione: Clinical Applications in Triple-Negative Breast Cancer and Environmental Hazards
- Zinc pyrithione's medical promise in TNBC contrasts with its environmental hazards, urging exploration of safer alternatives t....
- May 8，2024
- Zinc Pyrithione: A Promising Anti-Fungal Compound for Dermatologic Applications
- Zinc Pyrithione has high skin permeability and exhibits anti-fungal activity against Malassezia yeast, commonly used in medica....
- Jan 9，2024
- Why was zinc pyrithione banned?
- Zinc pyrithione, also called pyrithione zinc or ZPT, is a “coordination complex” of zinc and pyrithione. It’s an ingredient in....
- May 31，2023
13463-41-7(Zinc pyrithione)Related Search:
1of4
chevron_right