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N-(4-ACETAMIDOPHENYL)-INDOMETHACIN AMIDE

N-(4-ACETAMIDOPHENYL)-INDOMETHACIN AMIDE Structure
CAS No.
261766-23-8
Chemical Name:
N-(4-ACETAMIDOPHENYL)-INDOMETHACIN AMIDE
Synonyms
N-4AIA;N-4ACETIA;N-(4-ACETAMIDOPHENYL)-INDOMETHACIN AMIDE;N-(4-ACETAMIDOPHENYL)-1-P-CHLOROBENZOYL-5-METHOXY-2-METHYLINDOLE-3-ACETAMIDE;N-(4-ACETAMIDOPHENYL)-1-(4-CHLOROBENZOYL)-5-METHOXY-2-METHYL-1H-INDOLE-3-ACETAMIDE;1H-Indole-3-acetamide, N-[4-(acetylamino)phenyl]-1-(4-chlorobenzoyl)-5-methoxy-2-methyl-;N-4AcetIA, N-(4-Acetamidophenyl)-1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indole-3-acetamide
CBNumber:
CB6475024
Molecular Formula:
C27H24ClN3O4
Molecular Weight:
489.95
MOL File:
Mol file
Modify Date:
2023/5/18 11:31:03
Request For Quotation

N-(4-ACETAMIDOPHENYL)-INDOMETHACIN AMIDE Properties

Melting point 256-257°C
storage temp. −20°C
solubility DMSO: ≥15 mg/mL
form crystalline
color Pale Yellow

SAFETY

Risk and Safety Statements

WGK Germany  3

N-(4-ACETAMIDOPHENYL)-INDOMETHACIN AMIDE Chemical Properties,Uses,Production

Description

N-(4-acetamidophenyl)-indomethacin amide (N-4-AIA) is one of several aromatic amides of indomethacin reported to be potent and selective reversible inhibitors of COX-2. N-4-AIA inhibits human recombinant and ovine COX-2 with IC50 values of 0.12 and 0.625 μM, respectively. It is about 400 times less potent as an inhibitor of human recombinant COX-1 and 80 times less potent as an inhibitor of ovine COX-1 than ovine COX-2.

Chemical Properties

Pale Yellow Solid

Uses

An aromatic amide of indomethacin recently reported to be a potent and selective reversible inhibitor of COX-2. Inhibits human recombinant and ovine COX-2 with IC50 of 0.1 uM and 0.625 uM, respectively

N-(4-ACETAMIDOPHENYL)-INDOMETHACIN AMIDE Preparation Products And Raw materials

Raw materials

Preparation Products

N-(4-ACETAMIDOPHENYL)-INDOMETHACIN AMIDE Suppliers

Global( 21)Suppliers
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CLEARSYNTH LABS LTD. +91-22-45045900 Hyderabad, India 6351 58 Inquiry
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Cayman Chemical Company (800) 364-9897 United States 6618 81 Inquiry
Shanghai Yifei Biotechnology Co. , Ltd. 021-65675885 18964387627 China 8740 58 Inquiry
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Medical Isotopes 1-(603) 635-1722 United States 6185 68 Inquiry
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3B Pharmachem (Wuhan) International Co.,Ltd. 821-50328103-801 18930552037 China 15848 69 Inquiry
Toronto Research Chemicals +1 (416) 665-9696 Canada 6088 71 Inquiry
J & K SCIENTIFIC LTD. 010-82848833 400-666-7788 China 96815 76 Inquiry
Supplier Advantage
CLEARSYNTH LABS LTD. 58
MedBioPharmaceutical Technology Inc 58
Cayman Chemical Company 81
Shanghai Yifei Biotechnology Co. , Ltd. 58
Guangzhou Isun Pharmaceutical Co., Ltd 55
Medical Isotopes 68
SIGMA-RBI 91
3B Pharmachem (Wuhan) International Co.,Ltd. 69
Toronto Research Chemicals 71
J & K SCIENTIFIC LTD. 76

261766-23-8(N-(4-ACETAMIDOPHENYL)-INDOMETHACIN AMIDE)Related Search:

5-METHOXY-2-METHYLINDOLE
N-(4-ACETAMIDOPHENYL)-1-(4-CHLOROBENZOYL)-5-METHOXY-2-METHYL-1H-INDOLE-3-ACETAMIDE N-(4-ACETAMIDOPHENYL)-1-P-CHLOROBENZOYL-5-METHOXY-2-METHYLINDOLE-3-ACETAMIDE N-(4-ACETAMIDOPHENYL)-INDOMETHACIN AMIDE N-4ACETIA N-4AIA N-4AcetIA, N-(4-Acetamidophenyl)-1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indole-3-acetamide 1H-Indole-3-acetamide, N-[4-(acetylamino)phenyl]-1-(4-chlorobenzoyl)-5-methoxy-2-methyl- 261766-23-8 C27H24N3O4Cl C27H24ClN3O4 Biochemicals and Reagents BioChemical Application Index Cell Signaling Enzymes Cyclooxygenase Inhibitors Cyclooxygenase (COX) Enzymes Enzymes, Inhibitors, and Substrates Inhibitors Aromatics Heterocycles