Lapatinib 2-Fluoro Impurity

Lapatinib 2-Fluoro Impurity Structure
CAS No.
1393112-45-2
Chemical Name:
Lapatinib 2-Fluoro Impurity
Synonyms
Lapatinib Impurity 45;Lapatinib 2-Fluoro Analog;N-(3-Chloro-4-((2-fluorobenzyl)oxy)phenyl)-6-(5-(((2-(methylsulfonyl)ethyl)amino)methyl)furan-2-yl)quinazolin-4-amine;N-[3-Chloro-4-[(2-fluorophenyl)methoxy]phenyl]-6-[5-[[[2-(methylsulfonyl)ethyl]amino]methyl]-2-furanyl]-4-quinazolinamine;4-Quinazolinamine, N-[3-chloro-4-[(2-fluorophenyl)methoxy]phenyl]-6-[5-[[[2-(methylsulfonyl)ethyl]amino]methyl]-2-furanyl]-;N-(3-chloro-4-((2-fluorobenzyl)oxy)phenyl)-6-(5-(((2-(methylsulfonyl)ethyl)amino)methyl)furan-2-yl)quinazolin-4-amine bis(4-methylbenzenesulfonate)
CBNumber:
CB64798275
Molecular Formula:
C29H26ClFN4O4S
Molecular Weight:
581.06
MOL File:
1393112-45-2.mol
Modify Date:
2022/8/26 12:11:22

Lapatinib 2-Fluoro Impurity Properties

Boiling point 752.5±60.0 °C(Predicted)
Density 1.381±0.06 g/cm3(Predicted)
pka 6.34±0.19(Predicted)

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P261-P305+P351+P338

Lapatinib 2-Fluoro Impurity Chemical Properties,Uses,Production

Uses

3-Desfluoro 2-Fluoro Lapatinib is a compound related to drug Lapatinib (L175808), which is a selective inhibitor of epidermal growth factor receptor (EGFR) and HER-2 tyrosine kinases. Lapatinib is used to treat breast cancer, especially metastatic breast cancer that has progressed after trastuzumab treatment and other chemotherapy.

Lapatinib 2-Fluoro Impurity Preparation Products And Raw materials

Raw materials

Preparation Products

Lapatinib 2-Fluoro Impurity Suppliers

Lapatinib Impurity 45 Lapatinib 2-Fluoro Analog N-(3-chloro-4-((2-fluorobenzyl)oxy)phenyl)-6-(5-(((2-(methylsulfonyl)ethyl)amino)methyl)furan-2-yl)quinazolin-4-amine bis(4-methylbenzenesulfonate) N-[3-Chloro-4-[(2-fluorophenyl)methoxy]phenyl]-6-[5-[[[2-(methylsulfonyl)ethyl]amino]methyl]-2-furanyl]-4-quinazolinamine N-(3-Chloro-4-((2-fluorobenzyl)oxy)phenyl)-6-(5-(((2-(methylsulfonyl)ethyl)amino)methyl)furan-2-yl)quinazolin-4-amine 4-Quinazolinamine, N-[3-chloro-4-[(2-fluorophenyl)methoxy]phenyl]-6-[5-[[[2-(methylsulfonyl)ethyl]amino]methyl]-2-furanyl]- 1393112-45-2