SENECIONINE
- CAS No.
- 130-01-8
- Chemical Name:
- SENECIONINE
- Synonyms
- SENECIONIN;qlgn;Aureine;Sencionine;SENECIONINE;Senecionine/Aureine;16-dione,12-hydroxy-senecionan-1;12-Hydroxysenecionan-11,16-dione;Senecionan-11,16-dione, 12-hydroxy-;(15cis)-12-Hydroxysenecionan-11,16-dione
- CBNumber:
- CB6491042
- Molecular Formula:
- C18H25NO5
- Molecular Weight:
- 335.39
- MOL File:
- 130-01-8.mol
- Modify Date:
- 2024/7/2 8:55:14
| Melting point | 236 °C(lit.) |
|---|---|
| alpha | D25 -55.1° (c = 0.034 in chloroform) |
| Boiling point | 472.03°C (rough estimate) |
| Density | 1.266 g/cm3 |
| refractive index | 1.5100 (estimate) |
| storage temp. | −20°C |
| solubility | DMF: 5 mg/ml; DMSO: 2 mg/ml; Ethanol: 1 mg/ml; PBS (pH 7.2): 0.1 mg/ml |
| form | Solid |
| pka | 12.81±0.40(Predicted) |
| color | White to off-white |
| optical activity | [α]25/D 55.1°, c = 0.034% in chloroform |
| BRN | 8162955 |
| InChIKey | HKODIGSRFALUTA-JTLQZVBZSA-N |
| LogP | 0.880 (est) |
| EPA Substance Registry System | Senecionine (130-01-8) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS06 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H300+H310+H330 | |||||||||
| Precautionary statements | P262-P280-P301+P310+P330-P302+P352+P310-P304+P340+P310 | |||||||||
| Hazard Codes | T | |||||||||
| Risk Statements | 25 | |||||||||
| Safety Statements | 45 | |||||||||
| RIDADR | UN 2811 6.1/PG 3 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | VT5710000 | |||||||||
| F | 10-23 | |||||||||
| HazardClass | 6.1(a) | |||||||||
| PackingGroup | II | |||||||||
| Toxicity | LD50 i.v. in mice: 64.12 ±2.24 mg/kg (Harris) | |||||||||
| NFPA 704 |
|
SENECIONINE price More Price(3)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | 17806 | Senecionine ≥95.0% (GC) | 130-01-8 | 1MG | ₹14224.05 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 50351 | Senecionine analytical standard | 130-01-8 | 5MG | ₹49968.2 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 17806 | Senecionine ≥95.0% (GC) | 130-01-8 | 5MG | ₹54309.03 | 2022-06-14 | Buy |
SENECIONINE Chemical Properties,Uses,Production
Description
Senecionine is a pyrrolizidine alkaloid that has been found in S. vulgaris and has hepatotoxic properties. It is metabolized by the cytochrome P450 (CYP) isoform CYP3A in the liver to the detoxification product senecionine N-oxide and reactive metabolites including dehydropyrrolizidine alkaloids and dehydrotetronecine. Senecionine (20 μM) induces mitochondrial depolarization and fragmentation in primary cultured mouse hepatocytes and increases apoptosis in a concentration-dependent manner. In rats, senecionine (35 mg/kg, p.o.) induces liver injury, increases serum levels of bilirubin and various bile acids, including taurocholic acid, glycocholic acid, and deoxycholic acid, and increases the activity of alanine aminotransferase and aspartate aminotransferase in serum. Senecionine-induced hepatotoxicity is associated with lipid peroxidation and glutathione depletion.
Definition
ChEBI: A pyrrolizidine alkaloid isolated from the plant species of the genus Senecio.
Safety Profile
Poison by intravenous,intraperitoneal, and possibly other routes. Anexperimental teratogen. Other experimental reproductiveeffects. Mutation data reported. When heated todecomposition it emits toxic fumes of NOx.
References
Grandval, Lajoux., Cornpt. rend., 120,1120 (1895)
Grandval, Lajoux., Bull. Soc. Chirn. Fr., 13,942 (1895)
Manske., Can. J. Res., S, 651 (1931)
Manske., ibid, 14B, 6 (1936)
Barger, Blackie., J. Chern. Soc., 584 (1937)
Blackie., Pharrn. J., 138,102 (1937)
Manske., Can. J. Res., 17B, I (1939)
SENECIONINE Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
| SynZeal Research Pvt Ltd | +1 226-802-2078 | Gujarat, India | 6522 | 58 | Inquiry |
| Chengdu Greenpure Biopharma CO.,Ltd | +8618283602253 | China | 952 | 58 | Inquiry |
| Chengdu GLP biotechnology Co Ltd | 028-87075086 13350802083 | CHINA | 1824 | 58 | Inquiry |
| Chengdu Biopurify Phytochemicals Ltd. | +8618080483897 | China | 3424 | 58 | Inquiry |
| BOC Sciences | +1-631-485-4226 | United States | 19553 | 58 | Inquiry |
| career henan chemical co | +86-0371-86658258 +8613203830695 | China | 29826 | 58 | Inquiry |
| Henan Alfa Chemical Co., Ltd | +8618339805032 | China | 13141 | 58 | Inquiry |
| Chengdu Youngshe Chemical Co., Ltd. | +8618108235634 | China | 2345 | 58 | Inquiry |
| Zibo Hangyu Biotechnology Development Co., Ltd | +86-0533-2185556 +8617865335152 | China | 10978 | 58 | Inquiry |
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