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Dynorphin A (1-13)

CAS No.: 72957-38-1

Chemical Name:: Dynorphin A (1-13)

Synonyms: Dyn(1-13);YGGFLRRIRPKLK;DYNORPHIN 1-13;DYNORPHIN A (1-13);sh-Oligopeptide-71;Dynorphin A1-13【pig】;Dynorphin A(1-13)【pig】;Dynorphin A(1-13)【rat】;DYNORPHIN A(HUMAN, 1-13);Dynphin A (1-13) Acetate

CBNumber:: CB6699152

Molecular Formula:: C75H126N24O15

Molecular Weight:: 1603.95

MOL File:: 72957-38-1.mol

Modify Date:: 2024/7/2 8:55:14

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Dynorphin A (1-13) Properties

Density	1.39±0.1 g/cm3(Predicted)
RTECS	JV7436666
storage temp.	Inert atmosphere,Store in freezer, under -20°C
form	Solid
pka	3.31±0.10(Predicted)
color	White to off-white
Water Solubility	Water: ≥ 60 mg/mL (37.41 mM)
Sequence	H-Tyr-Gly-Gly-Phe-Leu-Arg-Arg-Ile-Arg-Pro-Lys-Leu-Lys-OH
InChIKey	OVVIBUHLQIYUEU-JASZZEBFNA-N

SAFETY

Risk and Safety Statements

WGK Germany	3
HS Code	2933998090

Dynorphin A (1-13) price More Price(1)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich(India)	D7017	Dynorphin A Porcine Fragment 1-13 ≥97% (HPLC)	72957-38-1	1MG	₹16345.75	2022-06-14	Buy

Product number	Packaging	Price	Buy
D7017	1MG	₹16345.75	Buy

Dynorphin A (1-13) Chemical Properties,Uses,Production

Description

Dynorphin A(1-13), a tridecapeptide of the endogenous opioid peptides, has modest effects in reducing mild opiate withdrawal in humans. Previous studies revealed that dynorphin also potentiates the analgesic effect of morphine in morphine-tolerant rats and mice. The therapeutic potential of dynorphin A(1-13) is limited due to extensive metabolism by human metabolic enzymes resulting in an in vivo half-life of less than one minute. Chemical modifications of dynorphin A(1-13), such as N-methylation of Tyr1 and amidation of the C-terminus have been shown to be effective in protecting against the proteolytic enzymes in human plasma^[1].

Application

Dynorphin A (1-13) has been used as a test compound in the field asymmetric waveform ion mobility spectrometry coupled to mass spectrometry (FAIMS/IMS/MS).

Biochem/physiol Actions

Dynorphin A (1-13), a bioactive product of dynorphin A displays interaction with N-methyl- D-aspartate (NMDA) as well as with opioid receptors. It elevates intracellular calcium [Ca²⁺]i level and contributes to the loss of neurons affecting neuronal viability.

References

[1] B BRUGOS; G H. Metabolism of dynorphin A(1-13).[J]. Pharmazie, 2004.

Dynorphin A (1-13) Preparation Products And Raw materials

Raw materials

L-Lysine, N-[(phenylmethoxy)carbonyl]-L-tyrosylglycylglycyl-L-phenylalanyl-L-leucyl-N5-[imino[[(4-methoxy-2,6-dimethylphenyl)sulfonyl]amino]methyl]-L-ornithyl-N5-[imino[[(4-methoxy-2,6-dimethylphenyl)sulfonyl]amino]methyl]-L-ornithyl-L-isoleucyl-N5-[imino[[(4-methoxy-2,6-dimethylphenyl)sulfonyl]amino]methyl]-L-ornithyl-L-prolyl-N6-[(1,1-dimethylethoxy)carbonyl]-L-lysyl-L-leucyl-N6-[(1,1-dimethylethoxy)carbonyl]-, 1,1-dimethylethyl ester

Preparation Products

Dynorphin A (1-13) Suppliers

Global( 160)Suppliers

Supplier	Tel	Country	ProdList	Advantage	Inquiry
A.J Chemicals	91-9810153283	New Delhi, India	6124	58	Inquiry
Chengdu Youngshe Chemical Co., Ltd.	+8618108235634	China	2345	58	Inquiry
Henan Bao Enluo International TradeCo.，LTD	+86-17331933971 +86-17331933971	China	2503	58	Inquiry
Apextide Co Ltd	+86-15300650552 +86-15300650552	China	71	58	Inquiry
Zibo Hangyu Biotechnology Development Co., Ltd	+86-0533-2185556 +8617865335152	China	10978	58	Inquiry
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Hangzhou Hyper Chemicals Limited	+86-0086-57187702781 +8613675893055	China	242	58	Inquiry
Alpha Biopharmaceuticals Co., Ltd	+86-15542445688	China	888	58	Inquiry
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Supplier	Advantage
A.J Chemicals	58
Chengdu Youngshe Chemical Co., Ltd.	58
Henan Bao Enluo International TradeCo.，LTD	58
Apextide Co Ltd	58
Zibo Hangyu Biotechnology Development Co., Ltd	58
Nantong Guangyuan Chemicl Co,Ltd	58
Hangzhou Hyper Chemicals Limited	58
Alpha Biopharmaceuticals Co., Ltd	58
Shanghai Daken Advanced Materials Co.,Ltd	58
career henan chemical co	58

72957-38-1(Dynorphin A (1-13))Related Search:

DYNORPHIN B (1-13) H-TYR-GLY-GLY-PHE-LEU-ARG-ARG-ILE-ARG-PRO-OH LEU-ENKEPHALIN-ARG dynorphin B (1-29) DYNORPHIN B (1-9)

TYR-GLY-GLY-PHE-LEU-ARG-ARG-ILE-ARG-PRO-LYS-LEU-LYS-TRP-ASP-ASN-GLN-NH2 Dynorphin A (1-13) L-LEUCYL-L-ALANINE (D-ARG6)-DYNORPHIN A (1-13),[D-ARG6]-DYNORPHIN A (1-13), PORCINE DYNORPHIN A (2-13), PORCINE,DYNORPHIN A (2-13)

dynorphin amide (1-13), Ala(2)-(5-F-Phe)(4)- [D-ALA2]-DYNORPHIN A (1-13) AMIDE,[DALA2] DYNORPHIN A (1-13), AMIDE, PORCINE [DALA2, DARG6] DYNORPHIN A, (1-13), PORCINE,(D-ALA2,D-ARG6)-DYNORPHIN A (1-13) (ARG11,13)-DYNORPHIN A (1-13)-GLY-NH-(CH2)5-NH2,(ARG11,13)-DYNORPHIN A (1-13)-GLY-5-AMINO-PENTYLAMIDE DYNORPHIN A (1-11) AMIDE

DYNORPHIN A (1-10) AMIDE H-LYS-LEU-NH2 LEU-ENKEPHALIN AMIDE

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TYR-GLY-GLY-PHE-LEU-ARG-ARG-ILE-ARG-PRO-LYS-LEU-LYS TYR-GLY-GLY-PHE-LEU-ARG-ARG-ILE-ARG-PRO-LYS-LEU-LYS 5ACOH 6H2O TYR-GLY-GLY-PHE-LEU-ARG-ARG-ILE-ARG-PRO-LYS-LEU-LYS PORCINE YGGFLRRIRPKLK L-TYR-GLY-GLY-PHE-LEU-ARG-ARG-ILE-ARG-PRO-LYS-LEU-LYS DYNORPHIN A PORCINE FRAGMENT 1-13 DYNORPHIN A(HUMAN, 1-13) DYNORPHIN A (HUMAN, 1-13) (PORCINE, RAT, BOVINE) DYNORPHIN A (HUMAN, 1-13) (PORCINE, RAT, BOVINE) 5ACOH 6H2O DYNORPHIN A (1-13) DYNORPHIN A (1-13), PORCINE DYNORPHIN 1-13 H-TYR-GLY-GLY-PHE-LEU-ARG-ARG-ILE-ARG-PRO-LYS-LEU-LYS-OH DYNORPHIN A (2-13) SYNTHETIC >97% OPIOID AGONIST DYNORPHIN A (1-13) SYNTHETIC >97% OPIOID AGONIST Dynorphin A (1-13) (human, porcine) Porcine dynorphin A(1-13) H-Tyr-Gly-Gly-Phe-Leu-Arg-Arg-Ile-Arg-Pro-Lys-Leu-Lys-OH acetate salt dynorphin A, porcine, fragment 1-13 acetate Dyn(1-13) Dynorphin A(1-13)【pig】 Dynorphin A(1-13)【rat】 Dynorphin A1-13【pig】 Dynphin A (1-13) Acetate Dynorphin (1-17), Dynorphin (1-14) Porcine dynorphin A(1-13),Dynorphin A Porcine Fragment 1-13, BR 1-13-Dynorphin A (swine) Dynorphin A (1-13) USP/EP/BP Dynorphin (1-17), Dynorphin (1-13)(net) 1-13-Dynorphin A acetate salt Dynorphin A (1-13), porcine Acetate sh-Oligopeptide-71 72957-38-1 C75H126N24O15 Dynorphins Peptides Opioid Peptides BioChemical Biochemicals and Reagents Amino Acids and Peptides Opioid receptor and opioid-like receptor peptide DynorphinsPeptides for Cell Biology Dynorphins Neuropeptides Opioid Peptides