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N-Acetylneuraminic Acid Aldolase

CAS No.: 9027-60-5

Chemical Name:: N-Acetylneuraminic Acid Aldolase

Synonyms: C:C&B4;EC 4.1.3.3;Sialate lyase;NANA Aldolase;NEU5AC ALDOLASE;SIALIC ALDOLASE;Sialic acid lyase;Neuraminic aldolase;Neu5Ac Aldolase 001;Neuraminate aldolase

CBNumber:: CB6717825

Molecular Formula:

Molecular Weight:: 0

MOL File:: Mol file

Modify Date:: 2023/4/23 13:52:06

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N-Acetylneuraminic Acid Aldolase Properties

storage temp.	-20°C
form	powder
color	slightly yellow
BRN	2697172
EPA Substance Registry System	Lyase, acetylneuraminate (9027-60-5)

SAFETY

Risk and Safety Statements

Hazard Codes	Xi
Risk Statements	36/37/38
Safety Statements	23-24/25-60-37-26-22
WGK Germany	3
F	10

N-Acetylneuraminic Acid Aldolase price More Price(1)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich(India)	A6680	N-Acetylneuraminic Acid Aldolase from microorganisms lyophilized powder, ≥20?units/mg protein (biuret)	9027-60-5	25UNITS	₹83427.6	2022-06-14	Buy

Product number	Packaging	Price	Buy
A6680	25UNITS	₹83427.6	Buy

N-Acetylneuraminic Acid Aldolase Chemical Properties,Uses,Production

Uses

Sialic acid aldolase can be used to synthesize unnatural sugars of C(6) to C(10) for the design of antagonists and inhibitors of glycoenzymes.

General Description

Sialic acid aldolases, or N-acetylneuraminate lyases, catalyze the reversible aldol cleavage of N-acetylneuraminic acid to form pyruvate and N-acetyl-D-mannosamine. In nature, N-acetylneuraminate lyase mainly occurs in pathogens.

Purification Methods

Purify the aldolase by extraction with H2O, protamine precipitation, (NH4)2SO4 fractionation, Me2CO precipitation, acid treatment at pH 5.7 and precipitation at pH 4.5. The equilibrium constant for pyruvate + n-acetyl-D-mannosamine N-acetylneuraminidate at 37o is 0.64. The Km for N-acetylneuraminic acid is 3.9mM in phosphate at pH 7.2 and 37o. [Comb & Roseman Methods Enzymol 5 391 1962.] The enzyme from hog kidney (cortex) has been purified 1700-fold by extraction with H2O, protamine sulfate precipitation, (NH4)2SO4 fractionation, heating between 60-80o, a second (NH4)2SO4 fractionation and starch gel electrophoresis. The Km for N-acetylneuraminic acid is 1.5mM. [Brunetti et al. J Biol Chem 237 2447 1962.]

N-Acetylneuraminic Acid Aldolase Preparation Products And Raw materials

Raw materials

Preparation Products

N-Acetylneuraminic Acid Aldolase Suppliers

Global( 69)Suppliers

Supplier	Tel	Country	ProdList	Advantage	Inquiry
BOC Sciences	+1-631-485-4226	United States	19553	58	Inquiry
Chongqing Chemdad Co., Ltd	+86-023-6139-8061 +86-86-13650506873	China	39916	58	Inquiry
Hubei Xindesheng Material Technology Co., Ltd.	+8618971041571	China	174	58	Inquiry
Hefei TNJ Chemical Industry Co.,Ltd.	+86-0551-65418671 +8618949823763	China	34571	58	Inquiry
ANHUI WITOP BIOTECH CO., LTD	+8615255079626	China	23556	58	Inquiry
Dideu Industries Group Limited	+86-29-89586680 +86-15129568250	China	24200	58	Inquiry
NewCan Biotech Limited	+86-0571-86912261 +8613735419629	China	9980	58	Inquiry
LEAPCHEM CO., LTD.	+86-852-30606658	China	43348	58	Inquiry
Wuhan Fortuna Chemical Co.,Ltd	+8618007136271	China	5945	58	Inquiry
Lingyuan Bebiansen Biological Technology Co., Ltd	18642120371	China	7994	58	Inquiry

Supplier	Advantage
BOC Sciences	58
Chongqing Chemdad Co., Ltd	58
Hubei Xindesheng Material Technology Co., Ltd.	58
Hefei TNJ Chemical Industry Co.,Ltd.	58
ANHUI WITOP BIOTECH CO., LTD	58
Dideu Industries Group Limited	58
NewCan Biotech Limited	58
LEAPCHEM CO., LTD.	58
Wuhan Fortuna Chemical Co.,Ltd	58
Lingyuan Bebiansen Biological Technology Co., Ltd	58

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EC 4.1.3.3 N-ACETYLNEURAMINIC ACID ALDOLASE N-ACETYLNEURAMINIC ACID ALDORASE N-ACETYLNEURAMINATE PYRUVATE LYASE NEU5AC ALDOLASE N-ACETYLNEURAMINIC ACID ALDOLASE, FROM MICROORGANISM N-Acetylneuraminate Pyruvate Lyase, N-Acetylneuraminic Acid Lyase, NANA Aldolase, Sialic Aldolase Sialic acid aldolase - Aqueous solution Sialic acid aldolase - crystalline Lyase,acetylneuraminate N-Acetylneuraminic Acid Lyase N-Acetylneuraminate pyruvate-lyase (N-acetyl-D-mannosamine-forming) Sialic Acid Aldolase from Escherichia coli K12 N-Acylneuraminate lyase N-Acylneuraminic acid aldolase N-Acylneuraminic aldolase N-Acylneuraminic lyase Neuraminate aldolase Neuraminic acid aldolase Neuraminic aldolase Sialate lyase Sialate pyruvate-lyase Sialic acid lyase N-Acylneuraminate aldolase N-AcetylneuraMinic acid aldolase,froM MicroorganisMi NANA Aldolase SIALIC ALDOLASE SIALIC ACID ALDOLASE N-Acetylneuraminic acid Aldolase Escherichia coli N-ACETYLNEURAMINIC ACID ALDOLASE FROMESC HERICHIA C N-ACETYLNEURAMINIC ACID ALDOLASE >15 U/MG* n-acetylneuraminic acid aldolase from escherichia coli Neu5Ac Aldolase 001 N-Acetylneuraminic Acid Aldolase from microorganisms Native Microorganism N-Acetylneuraminic acid aldolase Native Escherichia coli N-Acetylneuraminic Acid Aldolase Sialic Acid Aldolase from Escherichia coli K12, Recombinant C:C&B4 N-Acetylneuraminic Acid Aldolase USP/EP/BP N-Acetylneuraminic Acid Aldolase，NAL 9027-60-5 Post-translational Modification Proteomics Proteomics and Protein Expression Metabolomics Glycoanalytical Enzymes General Metabolic Enzymes Enzymes for Protein Carbohydrate Modification Analysis Carbohydrate Metabolism Carbohydrate Analysis BioChemical Lyases Specialty Enzymes