N-Acetylneuraminic Acid Aldolase
- CAS No.
- 9027-60-5
- Chemical Name:
- N-Acetylneuraminic Acid Aldolase
- Synonyms
- C:C&B4;EC 4.1.3.3;Sialate lyase;NANA Aldolase;NEU5AC ALDOLASE;SIALIC ALDOLASE;Sialic acid lyase;Neuraminic aldolase;Neu5Ac Aldolase 001;Neuraminate aldolase
- CBNumber:
- CB6717825
- Molecular Formula:
- Molecular Weight:
- 0
- MOL File:
- Mol file
- Modify Date:
- 2023/4/23 13:52:06
storage temp. | -20°C |
---|---|
form | powder |
color | slightly yellow |
BRN | 2697172 |
EPA Substance Registry System | Lyase, acetylneuraminate (9027-60-5) |
SAFETY
Risk and Safety Statements
Hazard Codes | Xi |
---|---|
Risk Statements | 36/37/38 |
Safety Statements | 23-24/25-60-37-26-22 |
WGK Germany | 3 |
F | 10 |
N-Acetylneuraminic Acid Aldolase price More Price(1)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Sigma-Aldrich(India) | A6680 | N-Acetylneuraminic Acid Aldolase from microorganisms lyophilized powder, ≥20?units/mg protein (biuret) | 9027-60-5 | 25UNITS | ₹83427.6 | 2022-06-14 | Buy |
Product number | Packaging | Price | Buy |
---|---|---|---|
A6680 | 25UNITS | ₹83427.6 | Buy |
N-Acetylneuraminic Acid Aldolase Chemical Properties,Uses,Production
Uses
Sialic acid aldolase can be used to synthesize unnatural sugars of C(6) to C(10) for the design of antagonists and inhibitors of glycoenzymes.
General Description
Sialic acid aldolases, or N-acetylneuraminate lyases, catalyze the reversible aldol cleavage of N-acetylneuraminic acid to form pyruvate and N-acetyl-D-mannosamine. In nature, N-acetylneuraminate lyase mainly occurs in pathogens.
Purification Methods
Purify the aldolase by extraction with H2O, protamine precipitation, (NH4)2SO4 fractionation, Me2CO precipitation, acid treatment at pH 5.7 and precipitation at pH 4.5. The equilibrium constant for pyruvate + n-acetyl-D-mannosamine N-acetylneuraminidate at 37o is 0.64. The Km for N-acetylneuraminic acid is 3.9mM in phosphate at pH 7.2 and 37o. [Comb & Roseman Methods Enzymol 5 391 1962.] The enzyme from hog kidney (cortex) has been purified 1700-fold by extraction with H2O, protamine sulfate precipitation, (NH4)2SO4 fractionation, heating between 60-80o, a second (NH4)2SO4 fractionation and starch gel electrophoresis. The Km for N-acetylneuraminic acid is 1.5mM. [Brunetti et al. J Biol Chem 237 2447 1962.]
N-Acetylneuraminic Acid Aldolase Preparation Products And Raw materials
Raw materials
Preparation Products
Supplier | Tel | Country | ProdList | Advantage | Inquiry |
---|---|---|---|---|---|
BOC Sciences | +1-631-485-4226 | United States | 19553 | 58 | Inquiry |
Chongqing Chemdad Co., Ltd | +86-023-6139-8061 +86-86-13650506873 | China | 39916 | 58 | Inquiry |
Hubei Xindesheng Material Technology Co., Ltd. | +8618971041571 | China | 174 | 58 | Inquiry |
Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418671 +8618949823763 | China | 34571 | 58 | Inquiry |
ANHUI WITOP BIOTECH CO., LTD | +8615255079626 | China | 23556 | 58 | Inquiry |
Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | China | 24200 | 58 | Inquiry |
NewCan Biotech Limited | +86-0571-86912261 +8613735419629 | China | 9980 | 58 | Inquiry |
LEAPCHEM CO., LTD. | +86-852-30606658 | China | 43348 | 58 | Inquiry |
Wuhan Fortuna Chemical Co.,Ltd | +8618007136271 | China | 5945 | 58 | Inquiry |
Lingyuan Bebiansen Biological Technology Co., Ltd | 18642120371 | China | 7994 | 58 | Inquiry |
9027-60-5(N-Acetylneuraminic Acid Aldolase)Related Search:
1of4
chevron_right