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(R)-CPP

(R)-CPP Structure
CAS No.
126453-07-4
Chemical Name:
(R)-CPP
Synonyms
D-CPP;(R)-CCP;(R)-CPP;CPP (R)-;(R)CPP,(R) CPP;rac-(S*)-2-(2,4-Dichlorophenoxy)propanoic acid;rac-(2R*)-2-(2,4-Dichlorophenoxy)propionic acid;rac-(2R*)-2-(2,4-Dichlorophenoxy)propanoic acid;(R)-4-(3-phosphonopropyl)piperazine-2-carboxylic acid;[3-[(2R)-2-Carboxypiperazin-4-yl]propyl]phosphonic acid
CBNumber:
CB6725314
Molecular Formula:
C8H17N2O5P
Molecular Weight:
252.2
MOL File:
126453-07-4.mol
Modify Date:
2024/7/2 8:55:14
Request For Quotation

(R)-CPP Properties

Boiling point 546.7±60.0 °C(Predicted)
Density 1.408±0.06 g/cm3(Predicted)
storage temp. Desiccate at RT
solubility Water: 100mM
form White crystalline powder.
pka 1.89±0.20(Predicted)
color White to off-white
Water Solubility Soluble to 100 mM in water

(R)-CPP Chemical Properties,Uses,Production

Description

(R)-CPP is an NMDA receptor antagonist (Ki = 0.14 μM). It binds to NMDA receptors containing GluN2A, GluN2B, GluN2C, and GluN2D subunits with Ki values of 0.04, 0.3, 0.6, and 2 μM, respectively. It inhibits depolarization induced by NMDA in isolated hemisected frog spinal cord (pA2 = 6.56) and NMDA-induced sodium efflux from rat brain slices (pA2 = 6.2). (R)-CPP inhibits the clonic phase of sound-induced seizures in DBA/2 mice (ED50 = 65.8 μmol/kg) and the myoclonic phase of stroboscopic-induced seizures in P. papio photosensitive baboons (ED50 = 127 μmol/kg).

Uses

(R)-CPP is a piperazine derivative demonstrating highly potent NMDA receptor antagonism.

Biological Activity

Highly potent NMDA antagonist; more active isomer. Shows some selectivity for NR2A-containing receptors (K i values are 0.041, 0.27, 0.63 and 1.99 μ M for inhibition of NR2A-, NR2B-, NR2C- and NR2D-containing recombinant NMDA receptors respectively).

(R)-CPP Preparation Products And Raw materials

Raw materials

117414-78-5 D-4-[(2E)-3-PHOSPHONO-2-PROPENYL]-2-PIPERAZINECARBOXYLIC ACID

Preparation Products

(R)-CPP Suppliers

Global( 61)Suppliers
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TargetMol Chemicals Inc. +1-781-999-5354 +1-00000000000 United States 19892 58 Inquiry
Career Henan Chemica Co +86-0371-86658258 +8613203830695 China 30253 58 Inquiry
Hangzhou MolCore BioPharmatech Co.,Ltd. +86-057181025280; +8617767106207 China 49739 58 Inquiry
Nantong HI-FUTURE Biology Co., Ltd. +undefined18051384581 China 3136 58 Inquiry
Chengdu Lanqingting Biotech Company Limited 028-87856149; 15208320722 China 289 58 Inquiry
TargetMol Chemicals Inc. 4008200310 China 24017 58 Inquiry
Nantong Hi-Future Biotechnology Co., Ltd 18051384581 China 3059 58 Inquiry
Shanghai Tachizaki Biomedical Research Center 18014399201 China 2497 58 Inquiry
Energy Chemical 021-58432009 400-005-6266 China 44843 58 Inquiry
Dongying Kelinweier Chemical Co., Ltd. 0546-7701939 7701938 13506362063 China 59 64 Inquiry
Supplier Advantage
TargetMol Chemicals Inc. 58
Career Henan Chemica Co 58
Hangzhou MolCore BioPharmatech Co.,Ltd. 58
Nantong HI-FUTURE Biology Co., Ltd. 58
Chengdu Lanqingting Biotech Company Limited 58
TargetMol Chemicals Inc. 58
Nantong Hi-Future Biotechnology Co., Ltd 58
Shanghai Tachizaki Biomedical Research Center 58
Energy Chemical 58
Dongying Kelinweier Chemical Co., Ltd. 64

126453-07-4((R)-CPP)Related Search:

2-Piperazinemethanol (R)-PIPERAZINE-2-CARBOXYLIC ACID PIPERAZINE-2-CARBOXYLIC ACID D-SS-(N-METHYLAMINO)ALANINE 3-(N,N-Dimethylamino)-D-alanine
D-2,3-Diaminopropionic acid 3-Aminopropylphosphonic acid 3-(N,N-Diethylamino)-L-alanine (R)-CPP 4-CPP
4-METHYLPIPERAZINE-2-CARBOXYLIC ACID 2-Piperazinecarboxaldehyde Aminoacylproline Carboxypeptidase, CPP, Penicillocarboxypeptidase S-1, Proline Carboxypeptidase,CPP【NMDA receptor antagonist】 CHLORINATEDPOLYPROPYLENE(CPP) (R)-2-(2,4-Dichlorophenoxy)propanoic acid
azaleucine [CPP1-7, NPY19-23, Ala31, Aib32, Gln34]-Pancreatic polypeptide (+/-)-3-(2-CARBOXYPIPERAZIN-4-YL)-PROPYL-1-PHOSPHONIC ACID
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(R)-CPP (R)-CCP R(-)-3-(2-CARBOXYPIPERAZIN-4-YL)-PROPYL-1-PHOSPHONIC ACID D-CPP 3-((R)-2-CARBOXYLPIPERAZIN-4-YL)-PROPYL-1-PHOSPHONIC ACID 3-((R)-2-CARBOXYPIPERAZIN-4-YL)-PROPYL-1-PHOSPHONIC ACID 3-((R)-Carboxylpiperazin-4-yl)-propyl-1-phosphonic acid rac-(2R*)-2-(2,4-Dichlorophenoxy)propanoic acid rac-(2R*)-2-(2,4-Dichlorophenoxy)propionic acid rac-(S*)-2-(2,4-Dichlorophenoxy)propanoic acid [3-[(2R)-2-Carboxypiperazin-4-yl]propyl]phosphonic acid 3-[(2R)-2-Carboxypiperazine-4-yl]propane-1-ylphosphonic acid CPP (R)- 2-Piperazinecarboxylic acid, 4-(3-phosphonopropyl)-, (2R)- (R)-4-(3-phosphonopropyl)piperazine-2-carboxylic acid (R)CPP,(R) CPP 126453-07-4 C8H17N2O5P Glutamate Glutamate receptor