1-CYANOCYCLOBUTANECARBOXYLIC ACID ETHYL ESTER
- CAS No.
- 28246-87-9
- Chemical Name:
- 1-CYANOCYCLOBUTANECARBOXYLIC ACID ETHYL ESTER
- Synonyms
- Ethyl 1-cyanocyclobutane-1-carboxylate;ethyl 1-cyanocyclobutanecarboxylate;1-CYANOCYCLOBUTANECARBOXYLIC ACID ETHYL ESTER;1-Cyano-Cyclobutanecarboxylic Acid Ethyl Este;Cyclobutanecarboxylic acid, 1-cyano-, ethyl ester;*Guaiacol Impurity 1 (Guaiacol EP Impurity A)(Pyrocatechol);(Z)-3-hydroxy-1-[5-(thiophen-2-ylmethyl)-2-furanyl]-3-(1H-1,2,4-triazol-5-yl)-2-propen-1-one
- CBNumber:
- CB6801258
- Molecular Formula:
- C8H11NO2
- Molecular Weight:
- 153.18
- MOL File:
- 28246-87-9.mol
- Modify Date:
- 2023/4/27 16:27:43
SAFETY
Risk and Safety Statements
Symbol(GHS) | GHS07 |
---|---|
Signal word | Warning |
Hazard statements | H302+H312+H332 |
Precautionary statements | P280-P301+P312-P302+P352 |
HS Code | 2926907090 |
1-CYANOCYCLOBUTANECARBOXYLIC ACID ETHYL ESTER Chemical Properties,Uses,Production
Uses
1-CYANOCYCLOBUTANECARBOXYLIC ACID ETHYL ESTER can be used as organic synthesis intermediate and pharmaceutical intermediate, mainly used in laboratory research and development process and chemical and pharmaceutical production process.
Synthesis
4-(9>-cyclopentyl-5'-methyl-6>-oxo-5>,6>,8>,9>- tetrahydrospiro[cyclobutane-l,7'-pyrimido[4,5-b][l,4]diazepine]-2'-ylamino)-3- methoxybenzoic acid; [0521] Ethyl 1-cyanocyclobutanecarboxylate; To a solution of sodium ethoxide (21wt% in EtOH, 5.79 rnL, 15.5 mmol) in EtOH (25 mL), was added ethyl cyanoacetate(1.12 mL, 10.5 mmol), followed shortly thereafter by 1,1-dibromopropane (1.12 mL, 10 mmol). The reaction mixture was refluxed for 3 hrs. It was then concentrated, and diluted to ethyl acetate. The organic layer was washed with NaHCCh, brine, water, dried over Na2SO4 and concentrated in vacuo to obtain ethyl 1-cyanocyclobutanecarboxylate (1.17 g, 74% yield) as a red liquid. It was used directly for next step reaction.
1-CYANOCYCLOBUTANECARBOXYLIC ACID ETHYL ESTER Preparation Products And Raw materials
Raw materials
Preparation Products
Supplier | Tel | Country | ProdList | Advantage | Inquiry |
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ALS INDIA LIFE SCIENCES | +91-8977036379 +91-8977036379 | Hyderabad, India | 1879 | 58 | Inquiry |
Arasan Chemicals Private Limited | +91 (98) 2001-1049 | New Delhi, India | 96 | 0 | Inquiry |
A.J Chemicals | 91-9810153283 | New Delhi, India | 6124 | 58 | Inquiry |
CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
Changzhou Ditong Chemical Co.,Ltd | +86-0519-88299272 | China | 2169 | 58 | Inquiry |
Shanghai Daken Advanced Materials Co.,Ltd | +86-371-66670886 | China | 18642 | 58 | Inquiry |
career henan chemical co | +86-0371-86658258 +8613203830695 | China | 29824 | 58 | Inquiry |
Guangzhou Yuheng Pharmaceutical Technology Co., Ltd | +8613580539051 | CHINA | 21149 | 58 | Inquiry |
JIAXING REGEN CHEMICAL CO.,LTD | +8613385739570 | China | 226 | 58 | Inquiry |
Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | China | 10522 | 58 | Inquiry |