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ChemicalBook > Product Catalog >Organic Chemistry >Organic fluorine compound >1-(6-(trifluoroMethyl)pyridin-3-yl)ethanone

1-(6-(trifluoroMethyl)pyridin-3-yl)ethanone

1-(6-(trifluoroMethyl)pyridin-3-yl)ethanone Structure
CAS No.
358780-14-0
Chemical Name:
1-(6-(trifluoroMethyl)pyridin-3-yl)ethanone
Synonyms
1-(6-(Trifluoromethyl);1-(6-(Trifluoromethyl)pyridin-3-yl);5-Acetyl-2-(trifluoromethyl)pyridine;5-Acetyl-2-(trifluoromethyl)pyridine 97+%;[6-(TRIFLUOROMETHYL)PYRIDIN-3-YL]ETHANONE;1-[6-(Trifluoromethyl)-3-pyridyl]ethanone;1-[6-(TRIFLUOROMETHYL)PYRIDIN-3-YL]ETHANONE;1-(6-(trifluoroMethyl)pyridine-3-yl)ethanone;1-(6-(trifluoromethyl)pyridin-3-yl) ethenone;1-[6-(Trifluoromethyl)pyridin-3-yl]ethan-1-one
CBNumber:
CB6845081
Molecular Formula:
C8H6F3NO
Molecular Weight:
189.13
MOL File:
358780-14-0.mol
Modify Date:
2024/4/3 17:07:09
Request For Quotation

1-(6-(trifluoroMethyl)pyridin-3-yl)ethanone Properties

Boiling point 233.7±40.0 °C(Predicted)
Density 1.280±0.06 g/cm3(Predicted)
storage temp. Inert atmosphere,Room Temperature
pka -1.24±0.22(Predicted)
InChI InChI=1S/C8H6F3NO/c1-5(13)6-2-3-7(12-4-6)8(9,10)11/h2-4H,1H3
InChIKey NAUKVLRFGMDIAN-UHFFFAOYSA-N
SMILES C(=O)(C1=CC=C(C(F)(F)F)N=C1)C

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335-H302
Precautionary statements  P264-P280-P302+P352-P321-P332+P313-P362-P264-P270-P301+P312-P330-P501-P264-P280-P305+P351+P338-P337+P313P
HS Code  2933399990

1-(6-(trifluoroMethyl)pyridin-3-yl)ethanone Chemical Properties,Uses,Production

Uses

1-(6-(Trifluoromethyl)pyridin-3-yl)ethanone can be used as novel GPR119 agonists.

Synthesis

To a solution of 2-trifluoromethyl-5-bromopyridine (5.0 g, 22 mmol) in Et2O (50 mL) was added sec-BuLi (0.91 M in cyclohexane, 24 mL, 22 mmol) at -78 °C. After 10 minutes of stirring, N,N-dimethylaminoacetamide (2.3 mL, 24 mmol) dissolved in Et2O (10 mL) was added drop wise. Stirring was continued at -78 °C for 1 h and then at rt over night. The reaction mixture was poured into water (100 mL) and the water phase was extracted with Et2O (3×100 mL). Combined organics were washed with water and brine and dried (MgSO4). After careful evaporation of the solvent, the crude was purified by column chromotography (SiO2, pentane/ether 9/1) to give 1-(6-(Trifluoromethyl)pyridin-3-yl)ethanone (2.3 g, 12 mmol, 54%) as a light yellow solid. 1H NMR (CDCl3) δ 9.26 (br s, 1H) 8.43 (br d, J=5.6 Hz, 1H) 7.83 (br d, J=7.2 Hz, 1H) 2.71 (s, 3H).
1-(6-(Trifluoromethyl)pyridin-3-yl)ethanone synthesis

1-(6-(trifluoroMethyl)pyridin-3-yl)ethanone Preparation Products And Raw materials

Raw materials

Preparation Products

(S)-1-(6-(Trifluoromethyl)pyridin-3-yl)ethanamine

1-(6-(trifluoroMethyl)pyridin-3-yl)ethanone Suppliers

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ATK CHEMICAL COMPANY LIMITED 60
Tianjin Huiren Chemtech Co., Ltd 58
CONIER CHEM AND PHARMA LIMITED 58
career henan chemical co 58

358780-14-0(1-(6-(trifluoroMethyl)pyridin-3-yl)ethanone)Related Search:

N-BENZYL-5-OXO-2-(TRIFLUOROMETHYL)-5H-CHROMENO[2,3-B]PYRIDINE-3-CARBOXAMIDE N-METHOXY-N-METHYL-N'-[5-OXO-2-(TRIFLUOROMETHYL)-5H-CHROMENO[2,3-B]PYRIDIN-3-YL]UREA N-(2,6-DIMETHYLPHENYL)-5-OXO-2-(TRIFLUOROMETHYL)-5H-CHROMENO[2,3-B]PYRIDINE-3-CARBOXAMIDE N-(2,4-DIFLUOROPHENYL)-5-OXO-2-(TRIFLUOROMETHYL)-5H-CHROMENO[2,3-B]PYRIDINE-3-CARBOXAMIDE 5-OXO-2-(TRIFLUOROMETHYL)-N-[3-(TRIFLUOROMETHYL)BENZYL]-5H-CHROMENO[2,3-B]PYRIDINE-3-CARBOXAMIDE
S-ETHYL N-[5-OXO-2-(TRIFLUOROMETHYL)-5H-CHROMENO[2,3-B]PYRIDIN-3-YL]CARBAMOTHIOATE 5-OXO-N-(3-PYRIDINYLMETHYL)-2-(TRIFLUOROMETHYL)-5H-CHROMENO[2,3-B]PYRIDINE-3-CARBOXAMIDE METHYL N-[5-OXO-2-(TRIFLUOROMETHYL)-5H-CHROMENO[2,3-B]PYRIDIN-3-YL]CARBAMATE N,N-DIMETHYL-N'-[5-OXO-2-(TRIFLUOROMETHYL)-5H-CHROMENO[2,3-B]PYRIDIN-3-YL]UREA N-(4-CHLOROBENZYL)-5-OXO-2-(TRIFLUOROMETHYL)-5H-CHROMENO[2,3-B]PYRIDINE-3-CARBOXAMIDE
N-METHYL-5-OXO-2-(TRIFLUOROMETHYL)-5H-CHROMENO[2,3-B]PYRIDINE-3-CARBOXAMIDE N-ISOPROPYL-5-OXO-2-(TRIFLUOROMETHYL)-5H-CHROMENO[2,3-B]PYRIDINE-3-CARBOXAMIDE 5-OXO-2-(TRIFLUOROMETHYL)-N-[3-(TRIFLUOROMETHYL)PHENYL]-5H-CHROMENO[2,3-B]PYRIDINE-3-CARBOXAMIDE 5-OXO-2-(TRIFLUOROMETHYL)-5H-CHROMENO[2,3-B]PYRIDINE-3-CARBOXYLIC ACID N-ALLYL-5-OXO-2-(TRIFLUOROMETHYL)-5H-CHROMENO[2,3-B]PYRIDINE-3-CARBOXAMIDE
N-(4-CHLOROPHENYL)-5-OXO-2-(TRIFLUOROMETHYL)-5H-CHROMENO[2,3-B]PYRIDINE-3-CARBOXAMIDE 5-OXO-N-PHENYL-2-(TRIFLUOROMETHYL)-5H-CHROMENO[2,3-B]PYRIDINE-3-CARBOXAMIDE 5-OXO-N-(2-PYRIDINYLMETHYL)-2-(TRIFLUOROMETHYL)-5H-CHROMENO[2,3-B]PYRIDINE-3-CARBOXAMIDE
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5-Acetyl-2-(trifluoromethyl)pyridine 1-(6-(trifluoroMethyl)pyridine-3-yl)ethanone [6-(TRIFLUOROMETHYL)PYRIDIN-3-YL]ETHANONE 1-(6-(Trifluoromethyl) 1-(6-(Trifluoromethyl)pyridin-3-yl) 1-[6-(TRIFLUOROMETHYL)PYRIDIN-3-YL]ETHANONE ETHANONE, 1-[6-(TRIFLUOROMETHYL)-3-PYRIDINYL]- 1-[6-(Trifluoromethyl)pyridin-3-yl]ethan-1-one 5-Acetyl-2-(trifluoromethyl)pyridine 97+% 1-（6-(trifluoromethyl) -3-pyridine ） ethyl ketone 1-(6-(trifluoromethyl)pyridin-3-yl) ethenone 1-[6-(Trifluoromethyl)-3-pyridyl]ethanone 358780-14-0