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o-methylisourea

o-methylisourea Structure
CAS No.
2440-60-0
Chemical Name:
o-methylisourea
Synonyms
Methyl carbamimidate;o-methylisourea (abbreviate OMIU);o-methylisourea;o-Methylisouronium;Methoxyformamidine;ORTHO-METHYLISOUREA;24285-39-0 (Sulfate);Fluorouracil Impurity 16;29427-58-5 (Monosulfate);5329-33-9 (Hydrochloride)
CBNumber:
CB71013558
Molecular Formula:
C2H6N2O
Molecular Weight:
74.08
MOL File:
2440-60-0.mol
MSDS File:
SDS
Modify Date:
2025/1/16 8:57:44
Request For Quotation

o-methylisourea Properties

Melting point 44-45 °C
Boiling point 66.9±23.0 °C(Predicted)
Density 1.17±0.1 g/cm3(Predicted)
solubility free base readily sol most organic solvents. Salts sol water, methanol, ethanol.
pka pK1:9.72(＋1) (25°C)

o-methylisourea Chemical Properties,Uses,Production

Uses

O-methylisourea can be used in the synthesis of heterocyclic compounds; it is a guanylation reagent and a selective alkylating agent.

Application

Methyl Carbamimidate is preparation of Ph (3-methoxy-1,2,4-thiadiazol-5-yl)carbamate from O-methylisourea hydrochloride.

Preparation

O-methylisourea hydrochloride is prepared in 69-80% yield by adding 1.15 equiv  HCl(g) with ice cooling to cyanamide dissolved in excess anhydrous methanol. The free base is obtained  from the salt using powdered KOH in a water-ether mixture or with sodium methoxide in methanol. The  monoacetate salt can be prepared from the free base with 1 equiv of HOAc. Drying: vacuum desiccator  over P2O5.

storage

Salts are hygroscopic and should be stored in a desiccator even for  brief periods. Heating O-methylisourea to decomposition can liberate toxic fumes of NOx. Use in a fume  hood.

o-methylisourea Preparation Products And Raw materials

Raw materials

O-methylisourea

Preparation Products

2-Aminoimidazole GUANIDINOSUCCINIC ACID TOS-ARG-OH 2-Amino-4-methoxy-6-methyl-1,3,5-triazine 6-AMINO-2-METHOXY-4(1H)-PYRIMIDINONE

o-methylisourea Suppliers

Global( 22)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
Henan Tianfu Chemical Co.,Ltd. +86-0371-55170693 +86-19937530512 China 21628 55 Inquiry
Shenzhen Nexconn Pharmatechs Ltd +86-755-89396905 +86-15013857715 China 10406 58 Inquiry
DAYANG CHEM (HANGZHOU) CO.,LTD +8617705817739 China 53881 58 Inquiry
Shangqiu City construction union new energy technology Co., LTD 19711218988 18238092829 China 1239 58 Inquiry
Hubei Wanye Zhongcheng Chemical Reagent Co., Ltd. 18671296875 18671296875 China 4302 58 Inquiry
Yick-Vic Chemicals & Pharmaceuticals (HK) Ltd (852)2541 2772 China 6206 58 Inquiry
Waterstone Technology, LLC 317 644 0862 United States 6786 30 Inquiry
AmplaChem, Inc. +1 (412) 455-5567 United States 428 50 Inquiry
Eurolabs Limited 44 1625 850089 United Kingdom 6309 46 Inquiry
ARVI Fine Organic Chemicals Co., Ltd. +3741 622-014 United States 249 50 Inquiry
Supplier Advantage
Henan Tianfu Chemical Co.,Ltd. 55
Shenzhen Nexconn Pharmatechs Ltd 58
DAYANG CHEM (HANGZHOU) CO.,LTD 58
Shangqiu City construction union new energy technology Co., LTD 58
Hubei Wanye Zhongcheng Chemical Reagent Co., Ltd. 58
Yick-Vic Chemicals & Pharmaceuticals (HK) Ltd 58
Waterstone Technology, LLC 30
AmplaChem, Inc. 50
Eurolabs Limited 46
ARVI Fine Organic Chemicals Co., Ltd. 50

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24285-39-0 (Sulfate) 29427-58-5 (Monosulfate) 52328-05-9 (Sulfate[2:1]) 5329-33-9 (Hydrochloride) o-Methylisouronium o-methylisourea ORTHO-METHYLISOUREA Carbamimidic acid methyl ester Methoxyformamidine Carbamimidic acid,methyl ester (9CI) Fluorouracil Impurity 16 Methyl carbamimidate o-methylisourea (abbreviate OMIU) 2440-60-0 H2NCOCH3NH