4-[(1R,6R)-3-METHYL-6-(1-METHYLETHENYL)-2-CYCLOHEXEN-1-YL]-5-PENTYL-1,3-BENZENEDIOL
![4-[(1R,6R)-3-METHYL-6-(1-METHYLETHENYL)-2-CYCLOHEXEN-1-YL]-5-PENTYL-1,3-BENZENEDIOL Structure](CAS/GIF/22972-55-0.gif)
- CAS No.
- 22972-55-0
- Chemical Name:
- 4-[(1R,6R)-3-METHYL-6-(1-METHYLETHENYL)-2-CYCLOHEXEN-1-YL]-5-PENTYL-1,3-BENZENEDIOL
- Synonyms
- ABN-CBD;Abn CBD,AbnCBD;Cannabidiol, Abnormal;Abnormal Cannabidiol (Abn-CBD);Abn-CBD (Abnormal Cannabidiol);1-Hydroxy-3-n-Pentylcannabidiol;4-(p-Mentha-1,8-dien-3-yl)-5-pentylresorcinol;8-dien-3-yl-5-pentyl-4-p-mentha-(-)-(e)-resorcino;(e)-(-)-4-p-mentha-1,8-dien-3-yl-5-pentylresorcinol;Resorcinol, 4-p-mentha-1,8-dien-3-yl-5-pentyl-, (-)-(E)-
- CBNumber:
- CB7129456
- Molecular Formula:
- C21H30O2
- Molecular Weight:
- 314.46
- MOL File:
- 22972-55-0.mol
- Modify Date:
- 2024/10/23 13:36:13
| Boiling point | 446.4±45.0 °C(Predicted) |
|---|---|
| Density | 1.025±0.06 g/cm3(Predicted) |
| storage temp. | Desiccate at -20°C |
| solubility | Soluble in methyl acetate (supplied pre-dissolved - 5mg/ml) |
| form | Powder |
| pka | 9.94±0.45(Predicted) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS02,GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H225-H319-H336 | |||||||||
| Precautionary statements | P210-P240-P241-P242-P243-P261-P264-P271-P280-P303+P361+P353-P304+P340-P305+P351+P338-P312-P337+P313-P370+P378-P403+P233-P403+P235-P405-P501 | |||||||||
| NFPA 704 |
|
4-[(1R,6R)-3-METHYL-6-(1-METHYLETHENYL)-2-CYCLOHEXEN-1-YL]-5-PENTYL-1,3-BENZENEDIOL Chemical Properties,Uses,Production
Description
Abnormal cannabidiol is a synthetic cannabidiol agonist of GPR55 (EC50 = 2.5 μM in a GTPγS binding assay). It is selective for GPR55 over cannabinoid (CB) receptor 1 (CB1) and CB2 (EC50s = >30 μM for both in GTPγS binding assays). It is also a full agonist at GPR18, with an EC50 value of 0.835 μM for inducing p44/42 MAPK phosphorylation in HEK293 cells expressing GPR18. Abnormal cannabidiol increases migration of BV-2 microglial cells (EC50 = 0.6 μM). It induces endothelium-dependent vasodilation via a CB1-CB2-NO-independent mechanism and inhibits vasoconstriction induced by endothelin 1 (ET-1; ) in retinal arterioles, an effect that can be blocked by the calcium-sensitive potassium channel blocker apamin . Abnormal cannabidiol also decreases blood pressure in anesthetized rats when administered intravenously at a dose of 20 μg/g or when administered directly into the rostral ventrolateral medulla at 0.4 and 0.8 μg.
Biological Activity
Neurobehaviorally inactive cannabinoid that acts as a selective agonist for GPR55 (EC 50 values are 2.5, >30 and >30 μ M at GPR55, CB 1 and CB 2 receptors respectively). Increases phosphorylation of protein kinases in, and migration of, human umbilical vein endothelial cells.
4-[(1R,6R)-3-METHYL-6-(1-METHYLETHENYL)-2-CYCLOHEXEN-1-YL]-5-PENTYL-1,3-BENZENEDIOL Preparation Products And Raw materials
Raw materials
Preparation Products
4-[(1R,6R)-3-METHYL-6-(1-METHYLETHENYL)-2-CYCLOHEXEN-1-YL]-5-PENTYL-1,3-BENZENEDIOL Suppliers
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | United States | 32159 | 58 | Inquiry |
| Hangzhou MolCore BioPharmatech Co.,Ltd. | +86-057181025280; +8617767106207 | China | 49734 | 58 | Inquiry |
| Aladdin Scientific | United States | 52924 | 58 | Inquiry | |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | China | 9803 | 58 | Inquiry |
| TargetMol Chemicals Inc. | 4008200310 | China | 24642 | 58 | Inquiry |
| Cayman Chemical Company | (800) 364-9897 | United States | 6213 | 81 | Inquiry |
| Nantong QuanYi Biotechnology Co., Ltd | 0513-66337626 18051384581 | China | 5237 | 58 | Inquiry |
| 4008-099-669 | CHINA | 73043 | 58 | Inquiry | |
| Chengdu Peter-like Biotechnology Co., Ltd. | 028-81700200 13308200041 | China | 11183 | 58 | Inquiry |
| BOC Sciences | 1-631-485-4226; 16314854226 | United States | 12952 | 65 | Inquiry |