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Retigabine Dihydrochloride

Retigabine Dihydrochloride Structure
CAS No.
150812-13-8
Chemical Name:
Retigabine Dihydrochloride
Synonyms
D 20443;CS-2270;Retigabin.2HCl;Retigabine HCl;Retigabine 2HCL;Retigabine DiHCl;D20443 dihydrochloride;D-20443 dihydrochloride;D 20443 dihydrochloride;Retigabine Dihydrochloride
CBNumber:
CB71565451
Molecular Formula:
C16H20Cl2FN3O2
Molecular Weight:
376.2
MOL File:
150812-13-8.mol
MSDS File:
SDS
Modify Date:
2024/8/21 22:41:43
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Retigabine Dihydrochloride Properties

Melting point 168-170°C
storage temp. Hygroscopic, -20°C Freezer, Under Inert Atmosphere
solubility ≥18.8 mg/mL in DMSO; ≥52.4 mg/mL in H2O with gentle warming; ≥8.71 mg/mL in EtOH with gentle warming and ultrasonic
form solid
Stability Hygroscopic

Retigabine Dihydrochloride Chemical Properties,Uses,Production

Chemical Properties

Off-White Powder

Drug interactions

 A clinical interaction study showed that there was no pharmacokinetic interaction between phenobarbitone and retigabine in healthy subjects. Thus, no dosage adjustment is likely to be necessary when phenobarbitone and retigabine are coadministered to patients 

Uses

A new experimental anticonvulsant drug. Anxiolytic.
Retigabine Dihydrochloride (0.1 ~ 10 μM) induced a potassium current and hyperpolarized CHO-KCNQ2/Q3 cells but not in wild-type cells. In the 6-Hz psychomotor seizure model, Retigabine Dihydrochloride dose-dependently blocked seizures induced by either 32 or 44 mA current stimulation.

Biological Activity

Retigabine is a first-in-class k+ channel (kcnq) opener. kcnq channels are reported to be expressed predominantly in neurons and are critical determinants of cellular excitability, as shown by the occurrence of human genetic mutations in kcnq channels which underlie inheritable disorders including the syndrome of benign familial neonatal convulsions.

Retigabine Dihydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

Retigabine Dihydrochloride Suppliers

Global( 143)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
CLEARSYNTH LABS LTD. +91-22-45045900 Hyderabad, India 6351 58 Inquiry
Pharmaffiliates Analytics and Synthetics P. Ltd +91-172-5066494 Haryana, India 6773 58 Inquiry
Pharma Affiliates 172-5066494 Haryana, India 6761 58 Inquiry
Hebei Chuanghai Biotechnology Co,.LTD +86-13131129325 China 5866 58 Inquiry
Zibo Hangyu Biotechnology Development Co., Ltd +86-0533-2185556 +8617865335152 China 10991 58 Inquiry
career henan chemical co +86-0371-86658258 +8613203830695 China 29888 58 Inquiry
Xiamen AmoyChem Co., Ltd +86-592-6051114 +8618959220845 China 6387 58 Inquiry
Chongqing Chemdad Co., Ltd +86-023-6139-8061 +86-86-13650506873 China 39916 58 Inquiry
CONIER CHEM AND PHARMA LIMITED +8618523575427 China 49392 58 Inquiry
Hebei Yanxi Chemical Co., Ltd. +8617531190177 China 5873 58 Inquiry
Supplier Advantage
CLEARSYNTH LABS LTD. 58
Pharmaffiliates Analytics and Synthetics P. Ltd 58
Pharma Affiliates 58
Hebei Chuanghai Biotechnology Co,.LTD 58
Zibo Hangyu Biotechnology Development Co., Ltd 58
career henan chemical co 58
Xiamen AmoyChem Co., Ltd 58
Chongqing Chemdad Co., Ltd 58
CONIER CHEM AND PHARMA LIMITED 58
Hebei Yanxi Chemical Co., Ltd. 58

Retigabine Dihydrochloride Spectrum

Retigabine Dihydrochloride(150812-13-8)1HNMR

150812-13-8(Retigabine Dihydrochloride)Related Search:

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D 20443 Ethyl [2-amino-4-[[(4-fluorophenyl)methyl]amino]phenyl]carbamate Dihydrochloride N-(2-Amino-4-(4-fluorobenzylamino)phenyl)carbamic Acid Ethyl Ester Dihydrochloride Retigabine HCl D 20443 dihydrochloride Retigabine 2HCL D20443 dihydrochloride D-20443 dihydrochloride ethyl 2-aMino-4-(4-fluorobenzylaMino)phenylcarbaMate dihydrochloride Retigabin.2HCl Retigabine Dihydrochloride Ethyl 4-(4-fluorobenzylamino)-2-aminophenylcarbamate dihydrochloride Retigabine DiHCl D 20443 DIHYDROCHLORIDE; D-20443 DIHYDROCHLORIDE; D20443 DIHYDROCHLORIDE CS-2270 Retigabine (Ezogabine) DiHCl Retigabine D6 Dihydrochloride Retigabine dihydrochloride- Bio-X 150812-13-8 C16H20Cl2FN3O2 C16H18FN3O22HCl C16H19ClFN3O2 API Chemical Amines Amines Aromatics Intermediates & Fine Chemicals Pharmaceuticals