Pirfenidone
- CAS No.
- 53179-13-8
- Chemical Name:
- Pirfenidone
- Synonyms
- 5-methyl-1-phenylpyridin-2(1H)-one;5-Methyl-1-phenylpyridine-2(1H)-one;Pirespa;Pirfenidone CRS;5-METHYL-1-PHENYL-2-(1H)-PYRIDONE;S-7701;amr-69;PIRFENIDONE;PIRFINIDONE;S-7701,AMR-69
- CBNumber:
- CB5299210
- Molecular Formula:
- C12H11NO
- Molecular Weight:
- 185.22
- MOL File:
- 53179-13-8.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/8/14 18:30:21
| Melting point | 96-97°C |
|---|---|
| Boiling point | 329.1±15.0 °C(Predicted) |
| Density | 1.137±0.06 g/cm3(Predicted) |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | DMSO: ≥10 mg/mL, soluble |
| form | solid |
| pka | -0.16±0.63(Predicted) |
| color | Off-white |
| Water Solubility | Soluble to 20 mM in water |
| Stability | Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month. |
| InChI | InChI=1S/C12H11NO/c1-10-7-8-12(14)13(9-10)11-5-3-2-4-6-11/h2-9H,1H3 |
| InChIKey | ISWRGOKTTBVCFA-UHFFFAOYSA-N |
| SMILES | C1(=O)N(C2=CC=CC=C2)C=C(C)C=C1 |
| CAS DataBase Reference | 53179-13-8(CAS DataBase Reference) |
Pirfenidone price More Price(4)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | P2116 | Pirfenidone ≥97% (HPLC) | 53179-13-8 | 10MG | ₹11983.28 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | P2116 | Pirfenidone ≥97% (HPLC) | 53179-13-8 | 50MG | ₹47402.68 | 2022-06-14 | Buy |
| TCI Chemicals (India) | P1871 | Pirfenidone min. 98.0 % | 53179-13-8 | 100MG | ₹8100 | 2022-05-26 | Buy |
| TCI Chemicals (India) | P1871 | Pirfenidone min. 98.0 % | 53179-13-8 | 1G | ₹20800 | 2022-05-26 | Buy |
Pirfenidone Chemical Properties,Uses,Production
Description
Until recently, IPF therapy consisted of a combination of corticosteroids and immunosuppressive agents (azathioprine and cyclophosphamide) to target the inflammation that was believed to be the pathogenic stimulus.Since IPF is now considered to be predominantly a disorder of fibroproliferation, agents that intervene in fibrogenesis have moved to the forefront of treatment options. With demonstrated efficacy in a bleomycin-induced lung fibrosis animal model, pirfenidone has been developed and launched as an approved therapy for IPF. Its antifibrotic activity is derived from the inhibition of p38 MAP kinase that is upstream of transforming growth factor-β (TGF-β), a cytokine implicated in the stimulation of collagen synthesis and the inhibition of its degradation. Pirfenidone also inhibits the expression of TNF-α, IL-1, and ICAM-1, so it possesses the dual benefit of an anti-inflammatory and antifibrotic agent. This relatively simplistic drug is constructed by the copper-catalyzed reaction of 5-methyl-2(1H)-pyridinone with bromo- or chlorobenzene. .
Chemical Properties
Off-White Solid
Uses
Pirfenidone is in a group of medicines called antifibrotic agents. Pirfenidone has demonstrated activity in multiple fibrotic conditions, including those of the lung, kidney and liver. It affects your body’s immune system and reduces the amount of fibrosis (scarring) in the lungs. Pirfenidone is one of two medicines that are approved in Canada to treat Idiopathic Pulmonary Fibrosis (IPF). Another name for this medicine is Esbriet.
Definition
ChEBI: A pyridone that is 2-pyridone substituted at positions 1 and 5 by phenyl and methyl groups respectively. An anti-inflammatory drug used for the treatment of idiopathic pulmonary fibrosis.
General Description
Pirfenidone?(5-methyl-1-phenyl-2-[1H]-pyridone) is a synthetic derivative of pyridine.
Biological Activity
Antifibrotic agent, effective in models of pulmonary and lung fibrosis. Inhibits collagen production and fibroblast proliferation. Regulates cytokine levels following oral administration in vivo . Potent scavenger of free radicals and inhibitor of lipid peroxidation.
Pirfenidone Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| GLR Innovations | +91 9891111994 | New Delhi, India | 4542 | 58 | Inquiry |
| Siddhivinayakchemicals | +91-912225190111 +91-9819773074 | Mumbai, India | 42 | 58 | Inquiry |
| JMR BIO SCIENCES | +91 9036832872 | New Delhi, India | 66 | 58 | Inquiry |
| Flax Laboratories | +91-9867665132 +91-9867665132 | Maharashtra, India | 44 | 58 | Inquiry |
| Prajna generics pvt ltd | +91-9441174873 +91-9441174873 | Hyderabad, India | 24 | 58 | Inquiry |
| KARPSCHEM LABORATORIES | +91-7249203006 +91-7249203006 | Maharashtra, India | 786 | 58 | Inquiry |
| PANCHSHEEL ORGANICS LTD | +91-9821053955 +91-9324201019 | Mumbai, India | 82 | 58 | Inquiry |
| Nivika Chemo Pharma Pvt Ltd | +91-9824176501 +91-9824176501 | Gujarat, India | 15 | 58 | Inquiry |
| Sekhment pharmaventures | +91-9030088669 +91-9030088669 | Mumbai, India | 105 | 58 | Inquiry |
| Lupin Ltd | +91-8019896181 +91-8019896181 | Maharashtra, India | 93 | 58 | Inquiry |
| Supplier | Advantage |
|---|---|
| GLR Innovations | 58 |
| Siddhivinayakchemicals | 58 |
| JMR BIO SCIENCES | 58 |
| Flax Laboratories | 58 |
| Prajna generics pvt ltd | 58 |
| KARPSCHEM LABORATORIES | 58 |
| PANCHSHEEL ORGANICS LTD | 58 |
| Nivika Chemo Pharma Pvt Ltd | 58 |
| Sekhment pharmaventures | 58 |
| Lupin Ltd | 58 |
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