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ChemicalBook > Product Catalog >Organic Chemistry >Amides >Acyclic polyamines and their derivatives >Spermidine trihydrochloride

Spermidine trihydrochloride

Spermidine trihydrochloride Structure
CAS No.
334-50-9
Chemical Name:
Spermidine trihydrochloride
Synonyms
SPERMIDINE HCl;Spermidie 3HCL;SPERMIDINE HYDROCHLORIDE;SperMidine tri;SPERMIDINE 3HC;SPERMIDINE 3HCL;Spermidine 3HCl>98%;Spermidine·3hydrochloride;SPERMIDINE TRIHYDROCHLORIDE;SPERMIDINE.3HCLRESEARCH GRADE
CBNumber:
CB7223105
Molecular Formula:
C7H22Cl3N3
Molecular Weight:
254.63
MOL File:
334-50-9.mol
MSDS File:
SDS
Modify Date:
2024/7/31 17:39:26
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Spermidine trihydrochloride Properties

Melting point 257-259 °C(lit.)
storage temp. room temp
solubility H2O: 1 M at 20 °C, clear, colorless
form Crystalline Powder
color White
PH 3.0-6.0 (25℃, 1M in H2O)
Water Solubility Soluble in water (100 mg/ml), and ethanol.
λmax λ: 260 nm Amax: 0.2
λ: 280 nm Amax: 0.1
BRN 3552356
InChI InChI=1S/C7H19N3.3ClH/c8-4-1-2-6-10-7-3-5-9;;;/h10H,1-9H2;3*1H
InChIKey LCNBIHVSOPXFMR-UHFFFAOYSA-N
SMILES C(CCCN)NCCCN.Cl.Cl.Cl
CAS DataBase Reference 334-50-9(CAS DataBase Reference)
EPA Substance Registry System 1,4-Butanediamine, N-(3-aminopropyl)-, trihydrochloride (334-50-9)

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H315-H319
Precautionary statements  P264-P280-P302+P352-P305+P351+P338-P332+P313-P337+P313
Hazard Codes  Xi
Risk Statements  36/37/38
Safety Statements  26-36
WGK Germany  3
RTECS  EJ7023000
F  3-10
TSCA  Yes
HS Code  29212900
NFPA 704
1
2 0

Spermidine trihydrochloride price More Price(7)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich(India) S2501 Spermidine trihydrochloride ≥98% (TLC) 334-50-9 1G ₹4200.1 2022-06-14 Buy
Sigma-Aldrich(India) S2501 Spermidine trihydrochloride ≥98% (TLC) 334-50-9 5G ₹11658.53 2022-06-14 Buy
Sigma-Aldrich(India) S2501 Spermidine trihydrochloride ≥98% (TLC) 334-50-9 25G ₹45778.93 2022-06-14 Buy
Sigma-Aldrich(India) 85578 Spermidine trihydrochloride BioXtra, ≥99.5% (AT) 334-50-9 1G ₹2587.18 2022-06-14 Buy
Sigma-Aldrich(India) 85578 Spermidine trihydrochloride BioXtra, ≥99.5% (AT) 334-50-9 5G ₹9904.88 2022-06-14 Buy
Product number Packaging Price Buy
S2501 1G ₹4200.1 Buy
S2501 5G ₹11658.53 Buy
S2501 25G ₹45778.93 Buy
85578 1G ₹2587.18 Buy
85578 5G ₹9904.88 Buy

Spermidine trihydrochloride Chemical Properties,Uses,Production

Description

Spermidine trihydrochloride is a polyamine that inhibits neuronal nitric oxide synthase (nNOS) and binds and precipitates DNA. It may be used to purify DNA binding proteins. Additionally, spermidine stimulates T4 polynucleotide kinase activity. It is involved in growth, development, and the stress response in plants.

Chemical Properties

Spermidine trihydrochloride appears as white to off-white crystalline powder, which is soluble in water(100mg/ml-clear, colorless solution), very hygroscopic, and air-sensitive.

Chemical Reactivity

Spermidine hydrochloride is a white crystal at normal temperature and pressure. It is the hydrochloride form of spermidine.When it is used, it is often reacted with alkali to release a triamine structure.

Uses

Spermidine Trihydrochloride is a NOS1 inhibitor and NMDA and T4 activator. Polyamine that plays an important role in the regulation of cellular proliferation and differentiation. It was in a structural and functional study of polyamines, where potassium and sodium ions were found to promote different effects when binding with polyamines. Spermidine trihydrochloride has been used in fourier transform infrared spectroscopy (FTIR)characterization and in zeta-potential measurements.

Definition

Spermidine trihydrochloride powder is the trihydrochloride form of spermidine. Spermidine base is in liquid form, while Spermidine trihydrochloride is in powder form. Spermidine trihydrochloride is a more stable form because spermidine is very air-sensitive. Spermidine trihydrochloride powder benefits are the same as Spermidine benefits.

benefits

Spermidine trihydrochloride has been extensively studied for its potential health benefits, including its ability to modulate autophagy, enhance cardiovascular health, protect against neurodegenerative diseases, and exhibit antioxidant activity. Studies have shown that it can enhance cardiovascular health by promoting blood vessel relaxation, reducing oxidative stress, and improving mitochondrial function. It has also been suggested to have neuroprotective effects and may contribute to cognitive health and brain function. It has shown promising results in preclinical studies, demonstrating its ability to protect neurons, reduce inflammation, and enhance cellular resilience.

Biological Functions

Spermidine inhibits NOS1 (nNOS). Spermidine binds and precipitates DNA and may be used for purification of DNA binding proteins. Spermidine activates PNK (polynucleotide kinase T4). Spermidine binds to and activates NMDA and has been shown to potentiate NMDA-induced currents in a concentration-dependent manner.

General Description

Spermidine trihydrochloride is the hydrochloric acid neutralized salt of spermidine. Spermidine is a polyamine and a trivalent organic cation. It is a natural polyamine that stimulates cytoprotective macroautophagy/autophagy. External supplementation of spermidine extends lifespan and health span across species, including in yeast, nematodes, flies and mice. Spermidine trihydrochloride is a more stable form because spermidine is very air sensitive.

Biological Activity

Binds to the polyamine modulatory site of the NMDA receptor and has been described as an agonist based on its ability to enhance the binding of [ 3 H]-MK801.
Spermidine trihydrochloride is an aliphatic polyamine. Its crystalline structure has been studied. It has been reported to preserve the nuclei and prevent proteolytic degradation of histones during the macronuclei isolation from Tetrahymena pyriformis.

Purification Methods

Recrystallise the salt from dry 3% HCl in ethanol and adding dry Et2O if necessary. Filter it off rapidly and dry it in a vacuum desiccator. Alternatively centrifuge the crystals off, wash them with dry Et2O and dry them in a vacuum. [Beilstein 4 IV 1300.]

Spermidine trihydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

Spermidine trihydrochloride Suppliers

Global( 297)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
A.J Chemicals 91-9810153283 New Delhi, India 6124 58 Inquiry
Alfa Aesar 1 800 209 7001 Maharashtra, India 6913 58 Inquiry
Wuhan Konberd Biotech Co., Ltd +undefined18986093962 China 1376 58 Inquiry
Wuhan senwayer century chemical Co.,Ltd +undefined-27-86652399 +undefined13627115097 China 892 58 Inquiry
Bonerge(Hunan) Lifescience Co., Ltd. +86-731-82791134 +86-18801900056 China 30 58 Inquiry
Maintain Biotech Co., Ltd. +86-75589664337 +86-15112661142 China 53 58 Inquiry
Suzhou Yuanrui Bio-Tech Co., Ltd +86-18106132862 +86-18106132862 China 285 58 Inquiry
GIHI CHEMICALS CO.,LIMITED +8618058761490 China 49999 58 Inquiry
Wuhan Haorong Biotechnology Co.,ltd +86-18565342920; +8618565342920 China 289 58 Inquiry
Hangzhou Zelixir Biotech Co., Ltd. +8618867646786 China 232 58 Inquiry
Supplier Advantage
A.J Chemicals 58
Alfa Aesar 58
Wuhan Konberd Biotech Co., Ltd 58
Wuhan senwayer century chemical Co.,Ltd 58
Bonerge(Hunan) Lifescience Co., Ltd. 58
Maintain Biotech Co., Ltd. 58
Suzhou Yuanrui Bio-Tech Co., Ltd 58
GIHI CHEMICALS CO.,LIMITED 58
Wuhan Haorong Biotechnology Co.,ltd 58
Hangzhou Zelixir Biotech Co., Ltd. 58

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Spermidine trihydrochloride Spectrum

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4-butanediamine,n-(3-aminopropyl)-trihydrochloride 4-azoniaoctamethylenediammonium trichloride 1,8-DIAMINO-4-AZAOCTANE TRIHYDROCHLORIDE SPERMIDINE TRIHYDROCHLORIDE N-(3-AMINOPR OPYL)-1,4 Spermidine trihydrochloride, 99+% Spermidine·3hydrochloride SPERMIDINE 3HC SPERMIDINE.3HCLRESEARCH GRADE SPERMIDINE *3HClMOLECULAR BIOLOGY GRADE Spermidine trihydrochloride,N-(3-Aminopropyl)-1,4-butanediamine trihydrochloride SperMidine trihydrochloride, 99+% 5GR N1-(3-AMinopropyl)butane-1,4-diaMine trihydrochloride N-(3-aMinopropyl)butane-1,4-diaMinetrihydrochloride SperMidine tri SPERMIDINE TRIHYDROCHLORIDE BIOXTRA N-[3-AMINOPROPYL]-1,4-BUTANEDIAMINE 3 H CL N-(3-AMINOPROPYL)-1 4-BUTANEDIAMINE HYDROCHLORIDE N-(3-AMINOPROPYL)-1,4-BUTANEDIAMINE TRIHYDROCHLORIDE N-(3-AMINOPROPYL)-1,4-DIAMINOBUTANE 3HCL N-(3-AMINOPROPYL)-1,4-DIAMINO-BUTANE TRIHYDROCHLORIDE SPERMIDINE 3HCL SPERMIDINE TRIHYDROCHLORIDE 1,4-Butanediamine,N-(3-aminopropyl)-,trihydrochloride Spermidine, Trihydrochloride - CAS 334-50-9 - Calbiochem Spermidine trihydrochloride, ≥98(TLC) 4-Azaoctamethylenediamine trihydrochloride SPERMIDINE TRIHYDROCHLORIDE ISO 9001：2015 REACH Spermidine trihydrochloride 98% Spermidine trihydrochloride 5% SPERMIDINE HCl Spermidie 3HCL SPERMIDINE HYDROCHLORIDE N-[3-AMINOPROPYL]-1,4-BUTANEDIAMINE 3 H C Spermidine 3HCl>98% Natural biosynthesis of spermidine HCL N'-(3-aminopropyl)butane-1,4-diamine,trihydrochloride N'-(3-aminopropyl)butane-1,4-diamine 334-50-9 34-50-9 C7H19N3x3HCl C7H19N33HCl C7H19N3HCl NH2CH23NHCH24NH23HCl C7H19N33ClH BioChemika Ultra Application Index Cell Signaling Enzymes Biochemicals and Reagents Building Blocks BioChemical Amine Salts NOS Inhibitors Substrate Analogs Enzyme Inhibitors Enzyme Inhibitors by Type Enzymes, Inhibitors, and Substrates Crystallization Nitrogen Compounds