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ChemicalBook > Product Catalog >Biochemical Engineering >Inhibitors >Apoptosis >Mdm2 activator >4-(4-Methyl-1-piperazinyl)-7-nitrobenzofurazane 3-oxide

4-(4-Methyl-1-piperazinyl)-7-nitrobenzofurazane 3-oxide

4-(4-Methyl-1-piperazinyl)-7-nitrobenzofurazane 3-oxide Structure
CAS No.
58131-57-0
Chemical Name:
4-(4-Methyl-1-piperazinyl)-7-nitrobenzofurazane 3-oxide
Synonyms
XI-006;CS-230;NSC-207895;NSC 179940;XI-006，NSC-207895;NSC-207895 (XI-006);NSC-207895 NSC207895;XI-006 (NSC207895)=1119;4-(4-Methyl-1-piperazinyl)-7-nitrobenzofurazan 3-oxide;7-(4-Methyl-1-piperazinyl)-4-nitrobenzofurazane 1-oxide
CBNumber:
CB72382615
Molecular Formula:
C11H13N5O4
Molecular Weight:
279.25
MOL File:
58131-57-0.mol
MSDS File:
SDS
Modify Date:
2024/7/2 8:55:16
Request For Quotation

4-(4-Methyl-1-piperazinyl)-7-nitrobenzofurazane 3-oxide Properties

Boiling point 487.6±55.0 °C(Predicted)
Density 1.64
storage temp. Store at -20°C
solubility Limited solubility
form Powder
pka 6.23±0.42(Predicted)
color Brown to reddish brown

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H332-H335
Precautionary statements  P261-P280-P305+P351+P338

4-(4-Methyl-1-piperazinyl)-7-nitrobenzofurazane 3-oxide Chemical Properties,Uses,Production

Description

NSC 207895 is an inhibitor of the p53-binding protein MDMX. It decreases MDMX promoter activity in a reporter assay using HT-1080 cells in a concentration-dependent manner. NSC 207895 (5 μmol/L) decreases the expression and protein levels of MDMX and increases the expression of the p53 target gene CDKN1 (p21) in MCF-7 cells overexpressing MDMX. It also increases the expression of the pro-apoptotic genes PUMA, Bax, and PIG3. NSC 207895 (5 μmol/L) induces apoptosis and decreases cell viability in MCF-7 cells in a p53-dependent manner. It also induces p53-independent apoptosis in wild-type, mutated, and truncated p53 Ewing sarcoma cell lines (IC50s = 98.9-1,613, 236-299, and 121-396 nM, respectively) selectively over wild-type and p53-null osteosarcoma cells (IC50s = 3,690-5,416 and 2,143 nM, respectively).

Uses

NSC-207895 is an anticancer agent and p53 activator. This compound decreases the expression of MDMX but also induced the expression of MDM2. It can also be used in pharmacological activity and therapeutic use of reviving antibiotics in relation to prepared efflux pump inhibitors that interact with AcrA, membrane fusion protein of AcrAB-TolC multidrug efflux pump.

4-(4-Methyl-1-piperazinyl)-7-nitrobenzofurazane 3-oxide Preparation Products And Raw materials

Raw materials

Preparation Products

4-(4-Methyl-1-piperazinyl)-7-nitrobenzofurazane 3-oxide Suppliers

Global( 85)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
ATK CHEMICAL COMPANY LIMITED +undefined-21-51877795 China 32760 60 Inquiry
career henan chemical co +86-0371-86658258 +8613203830695 China 29825 58 Inquiry
Dideu Industries Group Limited +86-29-89586680 +86-15129568250 China 24607 58 Inquiry
Zhejiang J&C Biological Technology Co.,Limited +1-2135480471 +1-2135480471 China 10522 58 Inquiry
InvivoChem +1-708-310-1919 +1-13798911105 United States 6393 58 Inquiry
TargetMol Chemicals Inc. +1-781-999-5354 United States 19973 58 Inquiry
Wuhan Topule Biopharmaceutical Co., Ltd +8618327326525 China 8474 58 Inquiry
LEAPCHEM CO., LTD. +86-852-30606658 China 43348 58 Inquiry
Aladdin Scientific +1-+1(833)-552-7181 United States 57511 58 Inquiry
Amadis Chemical Company Limited 571-89925085 China 131980 58 Inquiry
Supplier Advantage
ATK CHEMICAL COMPANY LIMITED 60
career henan chemical co 58
Dideu Industries Group Limited 58
Zhejiang J&C Biological Technology Co.,Limited 58
InvivoChem 58
TargetMol Chemicals Inc. 58
Wuhan Topule Biopharmaceutical Co., Ltd 58
LEAPCHEM CO., LTD. 58
Aladdin Scientific 58
Amadis Chemical Company Limited 58

58131-57-0(4-(4-Methyl-1-piperazinyl)-7-nitrobenzofurazane 3-oxide)Related Search:

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TENOVIN-1 Temsirolimus Nutlin-3 Sunitinib Malate
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4-(4-Methyl-1-piperazinyl)-7-nitrobenzofurazan 3-oxide 4-(4-Methyl-1-piperazinyl)-7-nitrobenzofurazane 3-oxide 7-(4-Methyl-1-piperazinyl)-4-nitrobenzofurazane 1-oxide XI-006 (NSC207895)=1119 NSC-207895 NSC-207895 (XI-006) NSC 179940 4-(4-Methyl-1-piperazinyl)-7-nitro-2,1,3-benzoxadiazole 3-oxide 2,1,3-Benzoxadiazole, 4-(4-methyl-1-piperazinyl)-7-nitro-, 3-oxide XI-006 XI-006，NSC-207895 4-(4-Methyl-1-piperazinyl)-7-nitrobenzofurazane 3-oxide USP/EP/BP 7-(4-methylpiperazin-1-yl)-4-nitrobenzo[c][1,2,5]oxadiazole 1-oxide CS-230 NSC-207895 NSC207895 4-(4-methylpiperazin-1-yl)-7-nitro-3-oxido-2,1,3-benzoxadiazol-3-ium 7-(4-Methyl-1-piperazinyl)-4-nitro-2,1,3-benzoxadiazole 1-oxide 58131-57-0 Inhibitors Inhibitor