ChemicalBook > Product Catalog >Biochemical Engineering >Inhibitors >Apoptosis >p53 inhibitors >Pifithrin-α (PFTα)

Pifithrin-α (PFTα)

CAS No.: 63208-82-2

Chemical Name:: Pifithrin-α (PFTα)

Synonyms: PFTα;CS-607;CS-1772;PFTα HBr;(PFTαPifithrin-α;Zinc03874684;PIFITHRIN-ALPHA;Pifithrin-α HBr;PFT-α,Pifithrin-α

CBNumber:: CB9700743

Molecular Formula:: C16H19BrN2OS

Molecular Weight:: 367.3

MOL File:: 63208-82-2.mol

Modify Date:: 2023/6/30 15:45:59

Request For Quotation

Pifithrin-α (PFTα) Properties

Melting point	192.1-192.5 °C(lit.)
storage temp.	-20°C
solubility	DMSO: 20 mg/mL
form	powder
pka	9.11(at 25℃)
color	off-white
Stability	Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H302-H315-H319-H335
Precautionary statements	P261-P305+P351+P338
WGK Germany	3
HS Code	2934.20.8000

Pifithrin-α (PFTα) price More Price(6)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich(India)	P4359	Pifithrin-α ≥95% (HPLC), powder	63208-82-2	5MG	₹14460	2022-06-14	Buy
Sigma-Aldrich(India)	P4359	Pifithrin-α ≥95% (HPLC), powder	63208-82-2	10MG	₹23340	2022-06-14	Buy
Sigma-Aldrich(India)	506132	Pifithrin-α - CAS 63208-82-2 - Calbiochem A cell-permeable chemical inhibitor of p53.	63208-82-2	5MG	₹9280.01	2022-06-14	Buy
Sigma-Aldrich(India)	506132	Pifithrin-α - CAS 63208-82-2 - Calbiochem A cell-permeable chemical inhibitor of p53.	63208-82-2	10MG	₹21460	2022-06-14	Buy
TCI Chemicals (India)	P2751	Pifithrin-α	63208-82-2	10MG	₹4800	2022-05-26	Buy

Product number	Packaging	Price	Buy
P4359	5MG	₹14460	Buy
P4359	10MG	₹23340	Buy
506132	5MG	₹9280.01	Buy
506132	10MG	₹21460	Buy
P2751	10MG	₹4800	Buy

Pifithrin-α (PFTα) Chemical Properties,Uses,Production

Description

Pifithrin-α is an inactivator of p53 that blocks p53-dependent transcriptional activation and apoptosis. It prevents p53-mediated apoptosis induced by cytotoxic compounds in C8 cells at 10 μM and in human umbilical vein endothelial cells at 30 μM. Pifithrin-α can also protect cells from DNA damage-induced apoptosis by a p53-independent mechanism that might involve cyclin D1.

Uses

Pifithrin-α has been used:

to study the effect of specific p53 inhibitor on p53-upregulated modulator of apoptosis (PUMA) expression after transient global cerebral ischemia (tGCI)
as p53 inhibitor to treat PA1 cells
as a tumor protein p53 (TRP53) inhibitor, to treat mouse lung epithelial-12 (MLE-12) cells

General Description

A cell-permeable chemical inhibitor of p53. Reversibly inhibits p53-dependent transactivation of p53-responsive genes and reversibly blocks p53-mediated apoptosis. Inhibits p53-dependent growth arrest of human diploid fibroblasts in response to DNA damage but has no effect on p53-deficient fibroblasts. Protects normal tissues from the deleterious side effects of chemotherapy. Has been reported to protect neurons against β-amyloid peptide and glutamate-induced apoptosis.

Biological Activity

Inhibitor of p53; reversibly blocks p53-dependent transcriptional activation and apoptosis. Protects against neuronal death in models of stroke and neurodegenerative disorders. Active in vivo ; protects mice from the side-effects of cancer therapy associated with p53 induction. Potentially increases reprogramming efficiency of human somatic cells to induced pluripotent stem cells (iPSCs) by silencing p53. Also aryl hydrocarbon receptor (AHR) agonist, causes upregulation of AHR target gene CYP1A1 (EC 50 = 1.1 μ M).

Pifithrin-α (PFTα) Preparation Products And Raw materials

Raw materials

Preparation Products

Pifithrin-α (PFTα) Suppliers

Global( 129)Suppliers

Supplier	Tel	Country	ProdList	Advantage	Inquiry
A.J Chemicals	91-9810153283	New Delhi, India	6124	58	Inquiry
TCI Chemicals (India) Pvt. Ltd.	1800 425 7889	New Delhi, India	6778	58	Inquiry
Hangzhou FandaChem Co.,Ltd.	008657128800458; +8615858145714	China	9338	55	Inquiry
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	China	32760	60	Inquiry
BOC Sciences	+1-631-485-4226	United States	19553	58	Inquiry
SHANGHAI T&W PHARMACEUTICAL CO., LTD.	+86-021-61551413 +8618813727289	China	5738	58	Inquiry
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	United States	19892	58	Inquiry
Career Henan Chemica Co	+86-0371-86658258 +8613203830695	China	30253	58	Inquiry
Dideu Industries Group Limited	+86-29-89586680 +86-15129568250	China	26165	58	Inquiry
Zhejiang J&C Biological Technology Co.,Limited	+1-2135480471 +1-2135480471	China	10522	58	Inquiry

Supplier	Advantage
A.J Chemicals	58
TCI Chemicals (India) Pvt. Ltd.	58
Hangzhou FandaChem Co.,Ltd.	55
ATK CHEMICAL COMPANY LIMITED	60
BOC Sciences	58
SHANGHAI T&W PHARMACEUTICAL CO., LTD.	58
TargetMol Chemicals Inc.	58
Career Henan Chemica Co	58
Dideu Industries Group Limited	58
Zhejiang J&C Biological Technology Co.,Limited	58

Pifithrin-α (PFTα) Spectrum

Pifithrin-α (PFTα)(63208-82-2)¹HNMR

63208-82-2(Pifithrin-α (PFTα))Related Search:

PRIMA-1 PD 169316 TENOVIN-1 Bortezomib 5,5'-(2,5-FURANDIYL)BIS-2-THIOPHENEMETHANOL

CAL-101 Ibrutinib Rapamycin CP 31398 SB 239063

SB 202190 CYCLIC-PIFITHRIN-ALPHA 1H-INDOLE-5-CARBOXAMIDE, 97% JX401 FHPI HCL

2-Amino-4'-methylacetophenone Pifithrin-α (PFTα) CYCLIC PIFITHRIN-ALPHA,PIFITHRIN-ALPHA, CYCLIC,PIFITHRIN-ALPHA (CYCLIC) HYDROBROMIDE

chevron_left

1of4

chevron_right

1-(4-METHYLPHENYL)-2-(4,5,6,7-TETRAHYDRO-2-IMINO-3(2H)-BENZOTHIAZOLYL)ETHANONE, MONOHYDROBROMIDE Pifithrin-Hydrobromide 2-(2-imino-4,5,6,7-tetrahydrobenzothiazol-3-yl)-1-p-tolylethanone hydrobromide PFT-α,Pifithrin-α Zinc03874684 Ethanone, 1-(4-Methylphenyl)-2-(4,5,6,7-tetrahydro-2-iMino-3(2H)-benzothiazolyl)-, MonohydrobroMide PFTα hydrobroMide Pifithrin-alpha . HBr 2-(2-iMino-4,5,6,7-tetrahydrobenzo[d]thiazol-3(2H)-yl)-1-p-tolylethanone hydrobroMide Pifithrin-α (PFTα) 2-(2-imino-4,5,6,7-tetrahydro-1,3-benzothiazol-3-yl)-1-(4-methylphenyl)ethanone,hydrobromide Ethanone, 1-(4-methylphenyl)-2-(4,5,6,7-tetrahydro-2-imino-3(2H)-benzothiazolyl)-, hydrobromide (1:1) 1-(4-Methylphenyl)-2-(4,5,6,7-tetrahydro-2-imino-3(2H)-benzothiazolyl)ethanone hydrobromide Pifithrin-α Pifithrin Pifithrin-alpha (PFT&alpha 2-(2-IMINO-4,5,6,7-TETRAHYDROBENZOTHIAZOL-3-YL)-1-P-TOLYLETHANONE, HBR 1-(4-METHYLPHENYL)-2-(4,5,6,7-TETRAHYDRO-2-IMINO-3(2H)-BENZOTHIAZOLYL)ETHANONE HYDROBROMIDE PIFITHRIN-ALPHA PIFITHRIN-ALPHA HYDROBROMIDE PFTα HBr Pifithrin-α HBr Pifithrin-α( PFTα) HBr Pifithrin-α - CAS 63208-82-2 - Calbiochem CS-607 PIFITHRIN HYDROBROMIDE; PIFITHRIN-Α HYDROBROMIDE; PFTΑ HYDROBROMIDE CS-1772 Pifithrin-α hydrobromide PFTα Pifithrin-α 2-(2-imino-4,5,6,7-tetrahydrobenzothiazol-3-yl)-1-p-tolylethanone hydrobromide USP/EP/BP Pifithrin-Alpha(PFTalpha)1-(4-METHYLPHENYL)-2-(4,5,6,7-TETRAHYDRO-2-IMINO-3(2H)-BENZOTHIAZOLYL)ETHANONE, MONOHYDROBROMIDE Pifithrin-α (PFTα) PFTα hydrobromide Pifithrin-α (PFTα) HBr Pifithrin-a (PFTa) 63208-82-2 C16H18N2OSHBr Apoptosis Inhibitors Apoptosis and Cell Cycle Cell Biology Cell Signaling and Neuroscience BioChemical Inhibitors Caspases/Apoptosis Inhibitor