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PD 169316

PD 169316 Structure
CAS No.
152121-53-4
Chemical Name:
PD 169316
Synonyms
CS-497;PD169317;PD 169316, >97%;PD 169316, >=98%;PD169316(hanDMSO);PD169316/PD-169316;SB-203580 analogue (1);PD 169316 - CAS 152121-53-4 - Calbiochem;4-[4-(4-Fluorophenyl)-2-(4-nitrophenyl)-1H-imidazol-5-yl]pyridine;4-[5-(4-fluorophenyl)-2-(4-nitrophenyl)-1H-iMidazol-4-yl]pyridine
CBNumber:
CB7497465
Molecular Formula:
C20H13FN4O2
Molecular Weight:
360.34
MOL File:
152121-53-4.mol
MSDS File:
SDS
Modify Date:
2023/6/8 9:01:55
Request For Quotation

PD 169316 Properties

Boiling point 583.1±50.0 °C(Predicted)
Density 1.354±0.06 g/cm3(Predicted)
storage temp. 2-8°C
solubility DMSO: >10mg/mL
pka 9.09±0.10(Predicted)
form solid
color light orange

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS05,GHS06
Signal word  Danger
Hazard statements  H301-H315-H318-H335
Precautionary statements  P280-P301+P310+P330-P302+P352-P305+P351+P338+P310
Hazard Codes  Xn
Risk Statements  22-37/38-41
Safety Statements  26-39
RIDADR  UN 2811 6.1/PG 3
WGK Germany  3
HS Code  2933399990
NFPA 704
0
3 0

PD 169316 price More Price(5)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich(India) P9248 PD 169316 ≥98% (HPLC), solid 152121-53-4 5MG ₹17536.5 2022-06-14 Buy
Sigma-Aldrich(India) P9248 PD 169316 ≥98% (HPLC), solid 152121-53-4 25MG ₹76078.1 2022-06-14 Buy
Sigma-Aldrich(India) 513030 PD 169316 - CAS 152121-53-4 - Calbiochem A potent, cell-permeable, reversible, competitive, and selective p38 MAP kinase inhibitor (IC?? = 89 nM). 152121-53-4 1MG ₹17860 2022-06-14 Buy
TCI Chemicals (India) P2532 PD 169316 152121-53-4 10MG ₹6800 2022-05-26 Buy
TCI Chemicals (India) P2532 PD 169316 152121-53-4 50MG ₹14800 2022-05-26 Buy
Product number Packaging Price Buy
P9248 5MG ₹17536.5 Buy
P9248 25MG ₹76078.1 Buy
513030 1MG ₹17860 Buy
P2532 10MG ₹6800 Buy
P2532 50MG ₹14800 Buy

PD 169316 Chemical Properties,Uses,Production

Description

p38 is a member of the mitogen-activated protein kinase (MAPK) superfamily of enzymes that play an important role in signal transduction. PD 169316 is a selective inhibitor of p38 MAPK. It inhibits p38 MAPK with an IC50 of 89 nM, whereas the IC50s are >100-fold higher for extracellular signal-regulated kinase (ERK) and >1,000-fold higher for protein kinase A (PKA) and PKCα. PD 169316 inhibits apoptosis of neuronal and non-neuronal cells deprived of specific trophic factors such as potassium or nerve growth factor.

Uses

PD 169316 is a highly selective, potent inhibitor of p38 MAP kinase. PD 169316 inhibits transforming growth factor β-induced Smad signaling in human ovarian cancer cells. PD 169316 acts as an an endogenous suppressor of apoptosis by mimicking CD9, a membrane tetraspanin. Studies show that PD 169316 reduces myocardial ischemia/reperfusion induced voltage-dependent anion channel(VDAC) phosphorylation

General Description

PD 169316 is a pyridinyl imidazole compound. It is a potential inhibitor of p38 mitogen-activated protein kinases. It also inhibits signalling transforming growth factor β (TGFβ), particularly in human ovarian cancer cells.

PD 169316 Preparation Products And Raw materials

Raw materials

Preparation Products

PD 169316 Suppliers

Global( 128)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
TCI Chemicals (India) Pvt. Ltd. 1800 425 7889 New Delhi, India 6778 58 Inquiry
CLEARSYNTH LABS LTD. +91-22-45045900 Hyderabad, India 6351 58 Inquiry
A.J Chemicals 91-9810153283 New Delhi, India 6124 58 Inquiry
Capot Chemical Co.,Ltd. 571-85586718 +8613336195806 China 29798 60 Inquiry
ATK CHEMICAL COMPANY LIMITED +undefined-21-51877795 China 32760 60 Inquiry
career henan chemical co +86-0371-86658258 +8613203830695 China 29900 58 Inquiry
CONIER CHEM AND PHARMA LIMITED +8618523575427 China 49391 58 Inquiry
TargetMol Chemicals Inc. +1-781-999-5354 +1-00000000000 United States 19892 58 Inquiry
Allfluoro pharmaceutical co. ltd. 021-26137118 +8615821363818 China 5791 58 Inquiry
Zhejiang J&C Biological Technology Co.,Limited +1-2135480471 +1-2135480471 China 10522 58 Inquiry
Supplier Advantage
TCI Chemicals (India) Pvt. Ltd. 58
CLEARSYNTH LABS LTD. 58
A.J Chemicals 58
Capot Chemical Co.,Ltd. 60
ATK CHEMICAL COMPANY LIMITED 60
career henan chemical co 58
CONIER CHEM AND PHARMA LIMITED 58
TargetMol Chemicals Inc. 58
Allfluoro pharmaceutical co. ltd. 58
Zhejiang J&C Biological Technology Co.,Limited 58

PD 169316 Spectrum

PD 169316(152121-53-4)1HNMR

152121-53-4(PD 169316)Related Search:

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4-[5-(4-fluorophenyl)-2-(4-nitrophenyl)-1H-iMidazol-4-yl]pyridine Pyridine, 4-[4-(4-fluorophenyl)-2-(4-nitrophenyl)-1H-iMidazol-5-yl]- PD169316/PD-169316 4-[4-(4-Fluorophenyl)-2-(4-nitrophenyl)-1H-imidazol-5-yl]pyridine 4-[4-(4-Fluorophenyl)-2-(4-nitrophenyl)-1H-imidazol-5-yl]pyridine PD 169316 PD 169316 4-[4-(4-Fluorophenyl)-2-(4-nitrophenyl)-1H-imidazol-5-yl]pyridine PD 169316, >=98% PD 169316, >97% CS-497 PD 169316 - CAS 152121-53-4 - Calbiochem PD169317 PD169316(hanDMSO) SB-203580 analogue (1) 152121-53-4 C20H13FN4O2 Inhibitors Aromatics Heterocycles Intermediates & Fine Chemicals Pharmaceuticals Protein Kinase Inhibitors and Activators