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ChemicalBook > Product Catalogue >Biochemical Engineering >Inhibitors >Apoptosis >p53 inhibitors >Pifithrin-α (PFTα)

Pifithrin-α (PFTα)

Pifithrin-α (PFTα) Structure
  • ₹4800 - ₹23340
  • Product name: Pifithrin-α (PFTα)
  • CAS: 63208-82-2
  • MF: C16H19BrN2OS
  • MW: 367.3
  • EINECS:
  • MDL Number:MFCD00417851
  • Synonyms:1-(4-METHYLPHENYL)-2-(4,5,6,7-TETRAHYDRO-2-IMINO-3(2H)-BENZOTHIAZOLYL)ETHANONE, MONOHYDROBROMIDE;Pifithrin-Hydrobromide;2-(2-imino-4,5,6,7-tetrahydrobenzothiazol-3-yl)-1-p-tolylethanone hydrobromide;PFT-α,Pifithrin-α;Zinc03874684;Ethanone, 1-(4-Methylphenyl)-2-(4,5,6,7-tetrahydro-2-iMino-3(2H)-benzothiazolyl)-, MonohydrobroMide;PFTα hydrobroMide;Pifithrin-alpha . HBr
Price6 Properties Safety Information Description
6 prices
Selected condition：

Brand

  • TCI Chemicals (India)
  • Sigma-Aldrich(India)

Package

  • 5MG
  • 10MG
  • 50MG
  • ManufacturerTCI Chemicals (India)
  • Product numberP2751
  • Product descriptionPifithrin-α
  • Packaging10MG
  • Price₹4800
  • Updated2022-05-26
  • Buy
  • ManufacturerTCI Chemicals (India)
  • Product numberP2751
  • Product descriptionPifithrin-α
  • Packaging50MG
  • Price₹14800
  • Updated2022-05-26
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product number506132
  • Product descriptionPifithrin-α - CAS 63208-82-2 - Calbiochem A cell-permeable chemical inhibitor of p53.
  • Packaging5MG
  • Price₹9280.01
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberP4359
  • Product descriptionPifithrin-α ≥95% (HPLC), powder
  • Packaging5MG
  • Price₹14460
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product number506132
  • Product descriptionPifithrin-α - CAS 63208-82-2 - Calbiochem A cell-permeable chemical inhibitor of p53.
  • Packaging10MG
  • Price₹21460
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberP4359
  • Product descriptionPifithrin-α ≥95% (HPLC), powder
  • Packaging10MG
  • Price₹23340
  • Updated2022-06-14
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
TCI Chemicals (India) P2751 Pifithrin-α 10MG ₹4800 2022-05-26 Buy
TCI Chemicals (India) P2751 Pifithrin-α 50MG ₹14800 2022-05-26 Buy
Sigma-Aldrich(India) 506132 Pifithrin-α - CAS 63208-82-2 - Calbiochem A cell-permeable chemical inhibitor of p53. 5MG ₹9280.01 2022-06-14 Buy
Sigma-Aldrich(India) P4359 Pifithrin-α ≥95% (HPLC), powder 5MG ₹14460 2022-06-14 Buy
Sigma-Aldrich(India) 506132 Pifithrin-α - CAS 63208-82-2 - Calbiochem A cell-permeable chemical inhibitor of p53. 10MG ₹21460 2022-06-14 Buy
Sigma-Aldrich(India) P4359 Pifithrin-α ≥95% (HPLC), powder 10MG ₹23340 2022-06-14 Buy

Properties

Melting point :192.1-192.5 °C(lit.)
storage temp. :-20°C
solubility :DMSO: 20 mg/mL
form :powder
pka :9.11(at 25℃)
color :off-white
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning GHS hazard pictograms P264, P270, P301+P312, P330, P501
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

Pifithrin-α is an inactivator of p53 that blocks p53-dependent transcriptional activation and apoptosis. It prevents p53-mediated apoptosis induced by cytotoxic compounds in C8 cells at 10 μM and in human umbilical vein endothelial cells at 30 μM. Pifithrin-α can also protect cells from DNA damage-induced apoptosis by a p53-independent mechanism that might involve cyclin D1.

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Suppliers and manufacturers

A.J Chemicals TCI Chemicals (India) Pvt. Ltd.
Hangzhou FandaChem Co.,Ltd.
ATK CHEMICAL COMPANY LIMITED
BOC Sciences
SHANGHAI T&W PHARMACEUTICAL CO., LTD.
TargetMol Chemicals Inc.
Career Henan Chemica Co
Dideu Industries Group Limited
Zhejiang J&C Biological Technology Co.,Limited