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SB 239063

SB 239063 Structure
  • ₹6300 - ₹69128.45
  • Product name: SB 239063
  • CAS: 193551-21-2
  • MF: C20H21FN4O2
  • MW: 368.4
  • EINECS:
  • MDL Number:MFCD03792786
  • Synonyms:SB 239063;TRANS-1-(4-HYDROXYCYCLOHEXYL)-4-(4-FLUOROPHENYL)-5-(2-METHOXYPYRIDIMIDIN-4-YL)IMIDAZOLE;TRANS-1-(4-HYDROXYCYCLOHEXYL)-4-(4-FLUOROPHENYL)-5-(2-METHOXYPYRIMIDIN-4-YL) IMIDAZOLE;TRANS-1-(4-HYDROXYCYCLOHEXYL)-4-(FLUOROPHENYL)-5-(2-METHOXYPYRIMIDIN-4-YL) IMIDAZOLE;TRANS-4-[4-(4-FLUOROPHENYL)-5-(2-METHOXY-4-PYRIMIDINYL)-1H-IMIDAZOL-1-YL]CYCLOHEXANOL;Cyclohexanol, 4-[4-(4-fluorophenyl)-5-(2-methoxy-4-pyrimidinyl)-1H-imidazol-1-yl]-, trans-;SB 239063 - CAS 798558-40-4 - Calbiochem;CS-402
5 prices
Selected condition:

Brand

  • TCI Chemicals (India)
  • Sigma-Aldrich(India)

Package

  • 500μG
  • 5MG
  • 25MG
  • ManufacturerTCI Chemicals (India)
  • Product numberB5898
  • Product descriptionSB 239063
  • Packaging5MG
  • Price₹6300
  • Updated2022-05-26
  • Buy
  • ManufacturerTCI Chemicals (India)
  • Product numberB5898
  • Product descriptionSB 239063
  • Packaging25MG
  • Price₹14800
  • Updated2022-05-26
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product number559404
  • Product descriptionSB 239063 - CAS 798558-40-4 - Calbiochem A potent, cell-permeable, reversible, and ATP-competitive inhibitor of the α- and β-isoforms (IC?? = 44 nM), but not the γ- or δ-isoform (IC?? > 100 μ
  • Packaging500μG
  • Price₹19050
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberS0569
  • Product descriptionSB 239063 >98% (HPLC)
  • Packaging5MG
  • Price₹19322.63
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberS0569
  • Product descriptionSB 239063 >98% (HPLC)
  • Packaging25MG
  • Price₹69128.45
  • Updated2022-06-14
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
TCI Chemicals (India) B5898 SB 239063 5MG ₹6300 2022-05-26 Buy
TCI Chemicals (India) B5898 SB 239063 25MG ₹14800 2022-05-26 Buy
Sigma-Aldrich(India) 559404 SB 239063 - CAS 798558-40-4 - Calbiochem A potent, cell-permeable, reversible, and ATP-competitive inhibitor of the α- and β-isoforms (IC?? = 44 nM), but not the γ- or δ-isoform (IC?? > 100 μ 500μG ₹19050 2022-06-14 Buy
Sigma-Aldrich(India) S0569 SB 239063 >98% (HPLC) 5MG ₹19322.63 2022-06-14 Buy
Sigma-Aldrich(India) S0569 SB 239063 >98% (HPLC) 25MG ₹69128.45 2022-06-14 Buy

Properties

Melting point :206-207.2 °C
storage temp. :2-8°C
solubility :DMSO: 11 mg/mL
form :White solid
color :white
InChIKey :ZQUSFAUAYSEREK-WKILWMFISA-N

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning GHS hazard pictograms P264, P270, P301+P312, P330, P501
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P271 Use only outdoors or in a well-ventilated area.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312 IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352 IF ON SKIN: wash with plenty of soap and water.
P304+P340 IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P330 Rinse mouth.
P332+P313 IF SKIN irritation occurs: Get medical advice/attention.
P337+P313 IF eye irritation persists: Get medical advice/attention.
P362 Take off contaminated clothing and wash before reuse.
P403+P233 Store in a well-ventilated place. Keep container tightly closed.
P405 Store locked up.
P501 Dispose of contents/container to..…

Description

SB 239063 is a selective p38 MAPK inhibitor (IC50 = 44 nM for recombinant purified p38α). It displays greater than 220-fold selectivity for p38 MAPK over ERK, JNK1, and other kinases. SB 239063 has been shown to reduce inflammatory cytokine production in lipopolysaccharide-stimulated human peripheral blood monocytes (IC50s = 0.12 and 0.35 μM, respectively for IL-1 and TNF-α) and is neuroprotective following oral administration in a rat model of cerebral focal ischemia.

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