AHU-377 (heMicalciuM salt)

CAS No.: 1369773-39-6

Chemical Name:: AHU-377 (heMicalciuM salt)

Synonyms: Sacubitril Calcium;Sacubitril hemicalcium;Sacubitril calcium salt;(alphar;LCZ696-1;Sabatrol calcium;AHU377 Calcium Salt;AHU-377 Hemicalcium;Sacubitrial Calcium;LCZ696 Impurity 534-06

CBNumber:: CB72685916

Molecular Formula:: C48H56CaN2O10

Molecular Weight:: 861.04364

MOL File:: 1369773-39-6.mol

MSDS File:: SDS

Modify Date:: 2024/9/19 18:11:18

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AHU-377 (heMicalciuM salt) Properties

Melting point	>140°C (dec.)
Density	1.24g/cm3 at 20℃
vapor pressure	0.001Pa at 20℃
storage temp.	-20°C
solubility	DMSO (Slightly, Heated), Methanol (Slightly)
form	powder
color	white to beige
LogP	-0.66-2.9 at 20℃ and pH2-7

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS06,GHS09

Signal word

Danger

Hazard statements

H301-H400

Precautionary statements

P273-P301+P310+P330

RIDADR

UN2811 - class 6.1 - PG 3 - EHS - Toxic solids, organic, n.o.s., HI: all

NFPA 704

	0
2		0

AHU-377 (heMicalciuM salt) price More Price(2)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich(India)	SML1380	Sacubitril calcium salt ≥98% (HPLC)	1369773-39-6	5MG	₹11431.2	2022-06-14	Buy
Sigma-Aldrich(India)	SML1380	Sacubitril calcium salt ≥98% (HPLC)	1369773-39-6	25MG	₹45410.88	2022-06-14	Buy

Product number	Packaging	Price	Buy
SML1380	5MG	₹11431.2	Buy
SML1380	25MG	₹45410.88	Buy

AHU-377 (heMicalciuM salt) Chemical Properties,Uses,Production

Uses

Sacubitril is an antihypertensive drug used in combination with valsartan. The combination drug, valsartan/sacubitril, known during trials as LCZ696 and marketed under the brand name, Entresto, is a treatment for heart failure.

Biochem/physiol Actions

Sacubitril (AHU377) is a prodrug inhibitor of the membrane metallo-endopeptidase neprilysin. Sacubitril forms half of the heart failure combination drug LCZ696, along with the angiotensin-receptor blocker Valsartan. Sacubitril (AHU377) is cojnverted by esterases into the active inhibitor LBQ657, which prevents neprilysin′s degradation of atrial and brain natriuretic peptide, two blood pressure lowering peptides. The AHU377 valsartan combination drug LCZ696 showed a reduction in the risk of cardiovascular death of 20% compared to the standard ACE inhibitor enalapril, and also a 21% drop in the risk of hospitalization.

AHU-377 (heMicalciuM salt) Preparation Products And Raw materials

Raw materials

Preparation Products

AHU-377 (heMicalciuM salt) Suppliers

Global( 279)Suppliers

Supplier	Tel	Country	ProdList	Advantage	Inquiry
Jigs Chemical ltd	+919099003427	Gujarat, India	239	58	Inquiry
Bulat Pharmaceutical Pvt Ltd	+91-8448085659 +91-8448085660	Haryana, India	123	58	Inquiry
Svak Life Sciences	+91-9963463333 +91-9705383777	Hyderabad, India	101	58	Inquiry
Venkatasai Life Sciences	+91-9908134868 +91-8008303069	Hyderabad, India	186	58	Inquiry
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LUPIN LTD	+91 124 4885000 / +91 124 3325000	New Delhi, India	191	58	Inquiry
A.J Chemicals	91-9810153283	New Delhi, India	6124	58	Inquiry
CLEARSYNTH LABS LTD.	+91-22-45045900	Hyderabad, India	6351	58	Inquiry

Supplier	Advantage
Jigs Chemical ltd	58
Bulat Pharmaceutical Pvt Ltd	58
Svak Life Sciences	58
Venkatasai Life Sciences	58
ExSyn Corp	58
Ami Lifesciences Pvt Ltd	58
Orgamine Chemicals(I) Pvt Ltd	58
LUPIN LTD	58
A.J Chemicals	58
CLEARSYNTH LABS LTD.	58

AHU-377 (heMicalciuM salt) Spectrum

AHU-377 (heMicalciuM salt)(1369773-39-6)¹HNMR

1369773-39-6(AHU-377 (heMicalciuM salt))Related Search:

AHU377-d4 Sacubitril-(2R,4R)-Isomer AHU-377 (2R,4S)-5-([1,1'-biphenyl]-4-yl)-4-aMino-2-Methylpentanoic acid hydrochloride LCZ696

(R,E)-5-([1,1'-biphenyl]-4-yl)-4-((tert-butoxycarbonyl)aMino)-2-Methylpent-2-enoic acid LCZ696 interMediate (2S,4S)-5-(Biphenyl-4-yl)-4-[(tert-butoxycarbonyl)amino]-2-methylpentanoic acid (2R,4S)-4-([1,1'-Biphenyl]-4-ylmethyl)-2-methyl-4-(2,5-dioxopyrrolidin-1-yl)butanoic acid (S)-5-[(Biphenyl-4-yl)methyl]-1-(2,2-dimethylpropionyl)pyrrolidin-2-one

Sacubitril Impurity 72 (2R,4S)-4-([1,1'-Biphenyl]-4-ylmethyl)-4-(4-ethoxy-4-oxobutanamido)-2-methylbutanoic acid ((R)-2-biphenyl-4-yl-1-forMylethyl)carbaMic acid t-butyl ester 2-Pyrrolidinone, 5-([1,1'-biphenyl]-4-ylMethyl)-3-Methyl-, (3R,5S)- Ethyl (2R,4S)-4-([1,1'-biphenyl]-4-ylmethyl)-2-methyl-4-(2,5-dioxopyrrolidin-1-yl)butanoate

sacubitril Valsartan (2R,4S)-5-([1,1'-biphenyl]-4-yl)-4-((tert-butoxycarbonyl)aMino)-2-Methylpentanoic acid Sacubitril Calcium

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AHU-377 (heMicalciuM salt) (alphaR,gammaS)-gamma-[(3-Carboxy-1-oxopropyl)amino]-alpha-methyl-[1,1'-biphenyl]-4-pentanoic acid 4-ethyl ester calcium salt (2:1) (2S,4R)-5-(Biphenyl-4-yl)-4-[(3-carboxypropionyl)amino]-2-methylpentanoic acid ethyl ester,calcium salt(2:1) AHU-377 hemicalcium salt (2:1) Calciumbis(4-{[(1S,3R)-1-([1,1'-biphenyl]-4-ylmethyl)-4-ethoxy-3-methyl-4-oxobutyl] amino} -4-oxobutanoate) Sacubitril Hemicalcium salt (αR,γS)-γ-[(3-Carboxy-1-oxopropyl)amino]-α-methyl-[1,1'-biphenyl]-4-pentanoic acid 4-ethyl ester calcium salt [1,1'-Biphenyl]-4-pentanoic acid, γ-[(3-carboxy-1-oxopropyl)amino]-α-methyl-, 4-ethyl ester, calcium salt (2:1), (αR,γS)- (alphaR, gammaS) -gamma-[(3- carbonyl, -1-, oxo propyl), amino]-alpha-, biphenyl, -4-, ethyl valerate, calcium salt LCZ696(valsartan + sacubitril) impurity 1 Ethyl (αR,γS)-γ-[(3-carboxy-1-oxopropyl)amino]-α-methyl-[1,1'-biphenyl]-4-pentanoate hemicalcium salt (alphar 1'-biphenyl]-4-pentanoic acid 4-ethyl ester calcium salt (2:1) gammas)-gamma-[(3-Carboxy-1-oxopropyl)amino]-alpha-methyl-[1 LCZ696-1 monocalciummono(4-(((2R,4S)-1-([1,1'-biphenyl]-4-yl)-5-ethoxy- 4-methyl-5-oxopentan-2-yl)amino)-4-oxobutanoate) Calcium4-(((2R,4S)-1-([1,1'-biphenyl]-4-yl)-5-ethoxy-4-methyl-5-oxopentan-2-yl)amino)-4-oxobutanoate (alphaR,gammaS)-gamma-[(3-Carboxy-1-oxopropyl)amino]-alpha-methyl-[1,1'-biphenyl]-4-pentanoic acid 4-ethyl ester calcium salt (2:1) (AHU-377 hemicalcium salt) AHU377 Calcium Salt AHU-377 Hemicalcium LCZ696 Impurity 534-06 (αR,γS)-γ-[(3-Carboxy-1-oxopropyl)amino]-α-methyl-[1,1'-biphenyl]-4-pentanoicacid4-ethylestercalciumsal LCZ696 intermediates，AHU-377 (heMicalciuM salt) (alphaR,gammaS)-gamma-[(3-Carboxy-1-oxopropyl)amino]-alpha-m... SACUBITRIL-13C4 CALCIUM Sacubitril-d5 Calcium Salt Sacubitril 13C4 CalciumQ: What is Sacubitril 13C4 Calcium Q: What is the CAS Number of Sacubitril 13C4 Calcium (αR,γS)-γ-[(3-Carboxy-1-oxopropyl)amino]-α-methyl-[1,1'-biphenyl]-4-pentanoic acid 4-ethyl ester calcium salt Sacubitril Calcium Sacubitril calcium salt Sacubitril hemicalcium LCZ-696 Impurity 29 calcium salt Ethyl (2R,4S)-5-(Biphenyl-4-yl)-4-(amino)-5-(3-carboxypropionyl)amino]-2-methylpentanoate, calcium salt Calcium 4-(((2S,4R)-1-([1,1'-biphenyl]-4-yl)-5-ethoxy-4-methyl-5-oxopentan-2-yl)amino)-4-oxobutanoate Calcium 4-((2S,4R)-1-(biphenyl-4-yl) -5-ethoxy-4-methyl-5-oxopentan-2-ylamino)-4-oxobutanoate Sacubitril calcium salt（AHU-377 ） Sacubitril Calcium Salt CRS Sacubitrol calcium salt (2R, 4S) -5- (biphenyl-4-yl) -4- (amino) -5- (3-carboxy-propionylamino-2-methyl-ventrate ethyl ester calcium salt Sacubitrial Calcium LCZ 696 hemicalcium salt LCZ696 hemicalcium salt Calcium 4-(((2S,4R)-1-([1,1'-biphenyl]-4-yl)-5-ethoxy-4-methyl-5-oxopentan-2-yl)amino)-4-oxobutanoate (alphaR,gammaS)-gamma-[(3-Carboxy-1-oxopropyl)amino]-alpha-methyl-[1,1'-biphenyl]-4-pentanoic acid 4-ethyl ester calcium salt Sabatrol calcium (alphaR,gammaS)-gamma-[(3-Carboxy-1-oxopropyl)amino]-alpha-methyl-[1,1'-biphenyl]-4-pentanoic acid 4-ethyl ester calcium salt (2:1) 1,1'-Biphenyl]-4-pentanoic acid, γ-[(3-carboxy-1-oxopropyl)amino]-α-methyl-, 4-ethyl ester, calcium salt (2:1), (αR,γS)- 1369773-39-6 2C24H29NO5Ca C48H56CaN2O10 Intermediates LCZ 696 Pharmaceutical Intermediates lcz696 1369773-39-6