2,5-Dibromopyridine
- CAS No.
- 624-28-2
- Chemical Name:
- 2,5-Dibromopyridine
- Synonyms
- Dibromopyridine;NSC 76597;5-DibroMopyridine;2,5-Dibrompyridin;2,5-dibromopyridin;2,5 dibromopyrdine;3,6-DibroMopyridine;2,5-DIBROMOPYRIDINE;2,5 Di bromo pyridne;Perampanel Impurity 9
- CBNumber:
- CB7283491
- Molecular Formula:
- C5H3Br2N
- Molecular Weight:
- 236.89
- MOL File:
- 624-28-2.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/4/9 13:47:46
| Melting point | 92-95 °C (lit.) |
|---|---|
| Boiling point | 235 °C / 772mmHg |
| Density | 2.0383 (rough estimate) |
| refractive index | 1.5800 (estimate) |
| Flash point | 62℃ |
| storage temp. | Inert atmosphere,Room Temperature |
| solubility | Chloroform (Slightly), Methanol (Slightly) |
| form | Crystalline Powder |
| pka | -1.57±0.10(Predicted) |
| color | Almost white or light beige to brown |
| Water Solubility | insoluble |
| BRN | 109099 |
| InChI | InChI=1S/C5H3Br2N/c6-4-1-2-5(7)8-3-4/h1-3H |
| InChIKey | ZHXUWDPHUQHFOV-UHFFFAOYSA-N |
| SMILES | C1(Br)=NC=C(Br)C=C1 |
| CAS DataBase Reference | 624-28-2(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H335-H302+H312+H332-H315-H319 | |||||||||
| Precautionary statements | P280a-P304+P340-P305+P351+P338-P405-P501a-P261-P264-P270-P271-P280-P301+P312+P330-P302+P352+P312+P362+P364-P304+P340+P312-P305+P351+P338+P337+P313-P501 | |||||||||
| Hazard Codes | Xi,Xn | |||||||||
| Risk Statements | 36/37/38-20/21/22 | |||||||||
| Safety Statements | 26-37/39-36/37/39-36 | |||||||||
| RIDADR | UN2811 | |||||||||
| WGK Germany | 3 | |||||||||
| HazardClass | IRRITANT | |||||||||
| HS Code | 29333999 | |||||||||
| NFPA 704 |
|
2,5-Dibromopyridine price More Price(4)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | D43107 | 2,5-Dibromopyridine 98% | 624-28-2 | 10G | ₹5630 | 2022-06-14 | Buy |
| TCI Chemicals (India) | D1217 | 2,5-Dibromopyridine min. 99.0 % | 624-28-2 | 5G | ₹2800 | 2022-05-26 | Buy |
| TCI Chemicals (India) | D1217 | 2,5-Dibromopyridine min. 99.0 % | 624-28-2 | 25G | ₹5300 | 2022-05-26 | Buy |
| TCI Chemicals (India) | D1217 | 2,5-Dibromopyridine min. 99.0 % | 624-28-2 | 500G | ₹46200 | 2022-05-26 | Buy |
2,5-Dibromopyridine Chemical Properties,Uses,Production
Chemical Properties
2,5-Dibromopyridine is an off-white crystalline solid. It is insoluble in water but soluble in strong polar organic solvents. It exhibits strong alkalinity.
Uses
2,5-Dibromopyridine (cas# 624-28-2) is a compound useful in organic synthesis.
Preparation
To synthesize 2,5-dibromopyridine, follow these steps:
Add 2-amino-5-bromopyridine (13.0 kg) into a water-cooled solution at 10 °C.
Slowly add 47% aqueous hydrogen bromide (37 L) to the mixture.
Introduce liquid bromine (11 L) into the mixture.
Maintain the reaction temperature below 10 °C.
Prepare a solution of NaNO2 (16.1 kg) and H2O (19 L) and add it dropwise to the mixture while keeping the temperature between 0-5 °C.
Stir the reaction mixture for 30 minutes.
Treat the mixture with a solution of NaOH (28.0 kg) in water (30 L) at a controlled rate below 20-25 °C.
Extract the reaction mixture with diethyl ether (3 × 40 L).
Dry the organic layer with anhydrous Na2SO4.
Remove the desiccant by filtration.
Evaporate the resulting filtrate under reduced pressure to dryness.
Suspend the residue in heptane (10 L).
Collect the target product molecule, 2,5-dibromopyridine, by filtration.
Synthesis method of 2,5-dibromopyridine
2,5-Dibromopyridine Preparation Products And Raw materials
Raw materials
Preparation Products
1of3
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