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AZD9496

AZD9496 Structure
CAS No.
1639042-08-2
Chemical Name:
AZD9496
Synonyms
AZD9496;CS-2107;AZD-9496;AZD 9496;AZD9496, 98%, a potent and selective estrogen receptor (ERα) antagonist;(E)-3-[3,5-Difluoro-4-[(1R,3R)-2-(2-fluoro-2-methylpropyl)-3-methyl-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indol-1-yl]phenyl]acrylic acid;3-[3,5-Difluoro-4-[(1r,3r)-2-(2-fluoro-2-methylpropyl)-2,3,4,9-tetrahydro-3-methyl-1h-pyrido[3,4-b]indol-1-yl]phenyl]-2-propenoic acid;2-Propenoic acid, 3-[3,5-difluoro-4-[(1R,3R)-2-(2-fluoro-2-methylpropyl)-2,3,4,9-tetrahydro-3-methyl-1H-pyrido[3,4-b]indol-1-yl]phenyl]-, (2E)-
CBNumber:
CB73041386
Molecular Formula:
C25H25F3N2O2
Molecular Weight:
442.47
MOL File:
1639042-08-2.mol
Modify Date:
2024/7/2 8:55:16
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AZD9496 Properties

Boiling point 541.0±50.0 °C(Predicted)
Density 1.286±0.06 g/cm3(Predicted)
storage temp. 4°C, protect from light, stored under nitrogen
solubility Soluble in DMSO
form A crystalline solid
pka 4.08±0.10(Predicted)
color Light yellow to brown

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P261-P264-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P321-P362+P364-P332+P313-P337+P313-P403+P233-P405-P501
NFPA 704
0
2 0

AZD9496 Chemical Properties,Uses,Production

Description

AZD 9496 is a potent and selective estrogen receptor downregulator (SERD) with an IC50 value of 0.138 nM for estrogen receptor α (ERα) downregulation. It is selective for ERα compared to other nuclear hormone receptors with IC50 values of 0.0008, 0.54, 9.2, and 30 μM for ERα, progesterone receptor (PR), glucocorticoid receptor (GR), and androgen receptor (AR), respectively. AZD 9496 decreases ERα activity (IC50 = 0.282 nM), measured via quantification of downstream PR activity, and reduces proliferation of MCF-7 breast cancer cells (IC50 = 0.0398 nM). It also inhibits MCF-7 xenograft growth in mice in a dose-dependent manner. AZD 9496 is orally bioavailable and formulations containing it are under investigation in clinical trials for treatment of ER positive breast cancer.

AZD9496 Preparation Products And Raw materials

Raw materials

Preparation Products

AZD9496 Suppliers

Global( 86)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
A.J Chemicals 91-9810153283 New Delhi, India 6124 58 Inquiry
CLEARSYNTH LABS LTD. +91-22-45045900 Hyderabad, India 6351 58 Inquiry
ATK CHEMICAL COMPANY LIMITED +undefined-21-51877795 China 32836 60 Inquiry
Zhejiang ZETian Fine Chemicals Co. LTD +8618957127338 China 2136 58 Inquiry
BOC Sciences +1-631-485-4226 United States 19553 58 Inquiry
career henan chemical co +86-0371-86658258 +8613203830695 China 29825 58 Inquiry
Zhejiang J&C Biological Technology Co.,Limited +1-2135480471 +1-2135480471 China 10522 58 Inquiry
CR Corporation Limited +8613062833949 China 8647 58 Inquiry
InvivoChem +1-708-310-1919 +1-13798911105 United States 6393 58 Inquiry
LEAP CHEM CO., LTD. +86-852-30606658 China 24738 58 Inquiry
Supplier Advantage
A.J Chemicals 58
CLEARSYNTH LABS LTD. 58
ATK CHEMICAL COMPANY LIMITED 60
Zhejiang ZETian Fine Chemicals Co. LTD 58
BOC Sciences 58
career henan chemical co 58
Zhejiang J&C Biological Technology Co.,Limited 58
CR Corporation Limited 58
InvivoChem 58
LEAP CHEM CO., LTD. 58

AZD9496 Spectrum

AZD9496(1639042-08-2)1HNMR

1639042-08-2(AZD9496)Related Search:

ESTETROL Ethylamine (-)-Varitriol BAY 11-7082 HMN-214
MS436
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(E)-3-[3,5-Difluoro-4-[(1R,3R)-2-(2-fluoro-2-methylpropyl)-3-methyl-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indol-1-yl]phenyl]acrylic acid 3-[3,5-Difluoro-4-[(1r,3r)-2-(2-fluoro-2-methylpropyl)-2,3,4,9-tetrahydro-3-methyl-1h-pyrido[3,4-b]indol-1-yl]phenyl]-2-propenoic acid AZD9496 AZD9496, 98%, a potent and selective estrogen receptor (ERα) antagonist CS-2107 AZD-9496;AZD 9496 2-Propenoic acid, 3-[3,5-difluoro-4-[(1R,3R)-2-(2-fluoro-2-methylpropyl)-2,3,4,9-tetrahydro-3-methyl-1H-pyrido[3,4-b]indol-1-yl]phenyl]-, (2E)- 1639042-08-2 API