ChemicalBook > Product Catalog >Biochemical Engineering >Inhibitors >Nuclear transcription factor (NF-κB) >IκB / IKK inhibitors >BAY 11-7082
BAY 11-7082
- CAS No.
- 19542-67-7
- Chemical Name:
- BAY 11-7082
- Synonyms
- BAY E;CS-608;100824;BAY-11708;BAY 11-7821;BAY 11-7082;BAY 11-7082, >=98%;BAY11-7082/BAY117082;BAY11-7082,BAY 117821;BAY 11-7082 USP/EP/BP
- CBNumber:
- CB9733804
- Molecular Formula:
- C10H9NO2S
- Molecular Weight:
- 207.25
- MOL File:
- 19542-67-7.mol
- MSDS File:
- SDS
- Modify Date:
- 2023/6/30 15:45:59
| Melting point | 133-135℃ |
|---|---|
| Boiling point | 397.6±42.0 °C(Predicted) |
| Density | 1.237±0.06 g/cm3(Predicted) |
| storage temp. | Keep in dark place,Inert atmosphere,2-8°C |
| solubility | DMSO: 25 mg/mL, soluble |
| form | solid |
| color | white |
| Stability | Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months. |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H315-H319 | |||||||||
| Precautionary statements | P501-P270-P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313-P301+P312+P330 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | UD1430000 | |||||||||
| HS Code | 2926907090 | |||||||||
| NFPA 704 |
|
BAY 11-7082 price More Price(5)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | B5556 | Bay 11-7082 ≥98% (HPLC), powder | 19542-67-7 | 10MG | ₹15003.45 | 2022-06-14 | Buy |
| Sigma-Aldrich | 196870 | BAY 11-7082 - CAS 19542-67-7 - Calbiochem The BAY 11-7082, also referenced under CAS 19542-67-7, controls the biological activity of TNF-α. This small molecule/inhibitor is primarily used for Inflammation/Immunology applications. | 19542-67-7 | 10MG | ₹12969.99 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 196870 | BAY 11-7082 - CAS 19542-67-7 - Calbiochem The BAY 11-7082, also referenced under CAS 19542-67-7, controls the biological activity of TNF-α. This small molecule/inhibitor is primarily used for | 19542-67-7 | 10MG | ₹12969.99 | 2022-06-14 | Buy |
| TCI Chemicals (India) | T2846 | BAY 11-7082 | 19542-67-7 | 100MG | ₹9700 | 2022-05-26 | Buy |
| TCI Chemicals (India) | T2846 | BAY 11-7082 | 19542-67-7 | 1G | ₹14500 | 2022-05-26 | Buy |
BAY 11-7082 Chemical Properties,Uses,Production
Uses
Bay 11-7082 has been used as:
- a nuclear factor-kappa B (NF-kB) inhibitor to verify the action of the NF-kB signaling pathway in the production of interleukin (IL)-8
- a nuclear factor-kappa B (NF-kB) inhibitor to study the role of NF-kB activation in Mycoplasma hyorhinis -induced epithelial-mesenchymal transition (EMT) and cell migration
- a nod-like receptor family pyrin domain containing 3 (NLRP3) selective inhibitor to examine its effects on liver inflammation in mice after hematopoietic stem cell transplantation
Definition
ChEBI: A nitrile that is acrylonitrile in which the hydrogen located beta,trans to the cyano group is replaced by a tosyl group. It is an inhibitor of cytokine-induced IkappaB-alpha phosphorylation i cells.
General Description
Potential anti-inflammatory agent that selectively and irreversibly inhibits the TNF-α-inducible phosphorylation of IκBα (IC50 = 10 μM), resulting in a decreased expression of NF-κB and of adhesion molecules. Does not affect constitutive IκBα autophosphorylation. Inhibits TNF-α-induced surface expression of the endothelial-leukocyte cell adhesion molecules E-selectin, VCAM-1, and ICAM-1. A 100 mM (10 mg/483 μl) solution of BAY 11-7082 (Cat. No. 196871) in DMSO is also available is also available.
Biological Activity
Irreversible inhibitor of TNF- α -stimulated I κ B α phosphorylation (IC 50 ~ 10 μ M); leads to decreased NF- κ B and subsequent decreased expression of adhesion molecules. Also reversibly activates MAP kinases and stimulates apoptosis.
BAY 11-7082 Preparation Products And Raw materials
Raw materials
Benzenesulfonyl iodide, 4-methyl-
1-(bromomethylsulfonyl)-4-methyl-benzene
Tosylphenyl selenide
2,3-Dibromopropionitrile
4-Methylbenzenesulfonhydrazide
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Global( 172)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| A.J Chemicals | 91-9810153283 | New Delhi, India | 6124 | 58 | Inquiry |
| CHEMSWORTH | +91-261-2397244 | New Delhi, India | 6707 | 30 | Inquiry |
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
| TCI Chemicals (India) Pvt. Ltd. | 1800 425 7889 | New Delhi, India | 6778 | 58 | Inquiry |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | China | 32760 | 60 | Inquiry |
| career henan chemical co | +86-0371-86658258 +8613203830695 | China | 29826 | 58 | Inquiry |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | United States | 19892 | 58 | Inquiry |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | China | 26114 | 58 | Inquiry |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | China | 10522 | 58 | Inquiry |
| InvivoChem | +1-708-310-1919 +1-13798911105 | United States | 6393 | 58 | Inquiry |
19542-67-7(BAY 11-7082)Related Search:
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BAY 11-7082
BAY 11-7821
(E)-3-(4-METHYLPHENYLSULFONYL)-2-PROPENENITRILE
(E)-3-tosylacrylonitrile
(E)-3-(p-Toluenesulfonyl)acrylonitrile
BAY11-7082/BAY117082
BAY11-7082,BAY 117821
(2E)-3-[(4-METHYLPHENYL)SULFONYL]-2-PROPENENITRILE
BAY11-7082 (E)-3-(p-Toluenesulfonyl)acrylonitrile
2-Propenenitrile, 3-[(4-methylphenyl)sulfonyl]-, (2E)-
Bay 11-7821 (2E)-3-[(4-Methylphenyl)sulfonyl]-2-propenenitrile
BAY 11-7082, >=98%
(E)-3-(p-tolylsulfonyl)prop-2-enenitrile
(e)-3-(4-methylphenyl)sulfonylprop-2-enenitrile
CS-608
100824
Bay 11-7821(BAY 11-7082)
BAY 11-7082 - CAS 19542-67-7 - Calbiochem
BAY11-7082;BAY11-7082;BAY 11-7082;BAY117082
BAY E
(2E)-3-[(4-Methylbenzene)sulfonyl]prop-2-enenitrile
BAY 11-7082 USP/EP/BP
BAY-11708
19542-67-7
Gene Regulation
Gene Regulation and Expression
BioChemical
Cell Signaling and Neuroscience
Cell Biology
Cytokine signaling
Inhibitors
NF-kB