ChemicalBook > Product Catalog >Biochemical Engineering >Inhibitors >Nuclear transcription factor (NF-κB) >IκB / IKK inhibitors >BAY 11-7085
BAY 11-7085
- CAS No.
- 196309-76-9
- Chemical Name:
- BAY 11-7085
- Synonyms
- CS-1876;BAY 117083;BAY 11-7085;BAY117085;BAY11-7085;BAY 11-7085 USP/EP/BP;BAY 11-7085;BAY-11-7085;BAY 11-7083;BAY 11-7085 - CAS 196309-76-9 - Calbiochem;(E)-3-(T-BUTYLPHENYLSULFONYL)-2-PROPENENITRILE;(E)-3-(4-tert-butylphenylsulfonyl)acrylonitrile;(E)3-[(4-T-BUTYLPHENYL)SULFONYL]-2-PROPENENITRILE
- CBNumber:
- CB0675833
- Molecular Formula:
- C13H15NO2S
- Molecular Weight:
- 249.33
- MOL File:
- 196309-76-9.mol
- MSDS File:
- SDS
- Modify Date:
- 2023/9/4 16:42:00
| Melting point | 80-82℃ |
|---|---|
| Boiling point | 407.1±45.0 °C(Predicted) |
| Density | 1.144 |
| Flash point | 200℃ |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | DMSO: >25 mg/mL, soluble |
| form | solid |
| color | white |
| Sensitive | Light Sensitive |
| InChIKey | VHKZGNPOHPFPER-ONNFQVAWSA-N |
| CAS DataBase Reference | 196309-76-9 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H315-H319-H335 | |||||||||
| Precautionary statements | P261-P280a-P304+P340-P305+P351+P338-P405-P501a | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | UD1312500 | |||||||||
| HS Code | 29309090 | |||||||||
| NFPA 704 |
|
BAY 11-7085 price More Price(3)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | B5681 | Bay 11-7085 ≥98% (HPLC), solid | 196309-76-9 | 10MG | ₹16551.43 | 2022-06-14 | Buy |
| TCI Chemicals (India) | B4845 | BAY 11-7085 | 196309-76-9 | 10MG | ₹7300 | 2022-05-26 | Buy |
| TCI Chemicals (India) | B4845 | BAY 11-7085 | 196309-76-9 | 100MG | ₹24800 | 2022-05-26 | Buy |
BAY 11-7085 Chemical Properties,Uses,Production
Uses
Bay 11-7085 has been used as:
- nuclear factor-κB inhibitor in Panc-1 cells, macrophages
- inhibitory κB kinase IKK inhibitor in human astrocytoma cells U87MGs
- phospho-p65 inhibitor human monocyte cell line THP-1
Biological Activity
Irreversible inhibitor of TNF- α -stimulated I κ B α phosphorylation (IC 50 ~ 10 μ M); leads to decreased NF- κ B and subsequent decreased expression of adhesion molecules. Also reversibly activates MAP kinases and stimulates apoptosis. Anti-inflammatory in vivo .
Biochem/physiol Actions
Bay 11-7085 inactivates peroxisome proliferator-activated receptors γ (PPAR-γ) and increases the microtubule-associated proteins 1A/1B light chain 3B (LC3B), a marker of autophagy resulting in apoptosis in human synovial fibroblasts. It promotes apoptosis in pancreatic carcinoma and may serve as radiotherapy-sensitizing drug. BAY 11-7085 decreases B-cell lymphoma 2 (Bcl-2) by inhibiting pI-κBα (inhibitor of nuclear factor κ B kinase subunit α
BAY 11-7085 Preparation Products And Raw materials
Raw materials
Preparation Products
Global( 106)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| A.J Chemicals | 91-9810153283 | New Delhi, India | 6124 | 58 | Inquiry |
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
| TCI Chemicals (India) Pvt. Ltd. | 1800 425 7889 | New Delhi, India | 6778 | 58 | Inquiry |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | China | 32760 | 60 | Inquiry |
| career henan chemical co | +86-0371-86658258 +8613203830695 | China | 29826 | 58 | Inquiry |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | United States | 19892 | 58 | Inquiry |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | China | 25247 | 58 | Inquiry |
| InvivoChem | +1-708-310-1919 +1-13798911105 | United States | 6393 | 58 | Inquiry |
| Aladdin Scientific | +1-+1(833)-552-7181 | United States | 57511 | 58 | Inquiry |
| bioleaper | 18601717983 | China | 5616 | 58 | Inquiry |
| Supplier | Advantage |
|---|---|
| A.J Chemicals | 58 |
| CLEARSYNTH LABS LTD. | 58 |
| TCI Chemicals (India) Pvt. Ltd. | 58 |
| ATK CHEMICAL COMPANY LIMITED | 60 |
| career henan chemical co | 58 |
| TargetMol Chemicals Inc. | 58 |
| Dideu Industries Group Limited | 58 |
| InvivoChem | 58 |
| Aladdin Scientific | 58 |
| bioleaper | 58 |
196309-76-9(BAY 11-7085)Related Search:
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BAY 117083 (2E)-3-[[4-(1,1-Dimethylethyl)phenyl]sulfonyl]-2-propenenitrile
(2E)-3-[[4-(1,1-DIMETHYLETHYL)PHENYL]SULFONYL]-2-PROPENENITRILE
(E)-3-(T-BUTYLPHENYLSULFONYL)-2-PROPENENITRILE
(E)3-[(4-T-BUTYLPHENYL)SULFONYL]-2-PROPENENITRILE
BAY 11-7085
(E)-3-(4-tert-butylphenylsulfonyl)acrylonitrile
BAY 117083
(2E)-3-[[4-(1,1-Dimethylethyl)phenyl]sulfonyl]-2-propenenitrile BAY 11-7085
BAY 11-7085 - CAS 196309-76-9 - Calbiochem
CS-1876
BAY117085;BAY11-7085
BAY 11-7085;BAY-11-7085;BAY 11-7083
(E)-3-(4-tert-butylphenyl)sulfonylprop-2-enenitrile
2-Propenenitrile, 3-[[4-(1,1-dimethylethyl)phenyl]sulfonyl]-, (2E)-
BAY 11-7085 USP/EP/BP
196309-76-9
C13H15O2NS
Gene Regulation and Expression
Gene Regulation
BioChemical
Cell Biology
Cell Signaling and Neuroscience
Inhibitors
Cytokine signaling