(Z)-Guggulsterone

(Z)-Guggulsterone Structure
CAS No.
95975-55-6
Chemical Name:
(Z)-Guggulsterone
Synonyms
GUGGULSTERONE;NSC 37445;Stersterone;GUGULSTERONE;GUGGULSTERONE Z;GUGGULESTERONES;GUGGULESTERONE Z;Coumarin sterone;CIS GUGGULSTERONE;Guggulsterone E&Z
CBNumber:
CB7309069
Molecular Formula:
C21H28O2
Molecular Weight:
312.45
MOL File:
95975-55-6.mol
Modify Date:
2023/5/18 11:31:20

(Z)-Guggulsterone Properties

Boiling point 463.3±45.0 °C(Predicted)
Density 1.10±0.1 g/cm3(Predicted)
storage temp. 2-8°C
solubility DMSO: 5 mg/mL
form powder
color light yellow
CAS DataBase Reference 95975-55-6(CAS DataBase Reference)

SAFETY

Risk and Safety Statements

Hazard Codes  Xi
Risk Statements  37
Safety Statements  36
WGK Germany  3
HS Code  29147000

(Z)-Guggulsterone Chemical Properties,Uses,Production

Uses

Guggulsterone is a broad spectrum steroid receptor ligand. Gum resin of Commiphora mukul marketed as an antihyperlipidemic drug.

Biological Activity

Broad spectrum steroid receptor ligand; binds with high affinity to mineralocorticoid receptors (K i = 39 nM) and lower affinity to progesterone, androgen and glucocorticoid receptors (K i values are 201, 240 and 224 nM respectively). Functions primarily as an antagonist of these receptors, with the exception of the progesterone receptor where it displays partial agonist effects. Also exerts hypolipidemic activity, likely via antagonism of the receptor for bile acids (farnesoid X receptor; FXR).

(Z)-Guggulsterone Preparation Products And Raw materials

Raw materials

Preparation Products

Global( 175)Suppliers
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Apollo ingredients Pvt Ltd +91-7219888886 Maharashtra, India 31 58 Inquiry
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Pharmaffiliates Analytics and Synthetics P. Ltd +91-172-5066494 Haryana, India 6773 58 Inquiry
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Medilink Pharmachem +91 (79) 3007-0133 New Delhi, India 424 50 Inquiry
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Chongqing Chemdad Co., Ltd +86-023-6139-8061 +86-86-13650506873 China 39916 58 Inquiry
4,17(20)-(CIS)-PREGNADIEN-3,16-DIONE PREGNA-4,17(20)-DIENE-3,16-DIONE (8S,9R,10R,13S,14S,17E)-17-(1-methoxyethylidene)-10,13-dimethyl-1,2,6,7,8,9,11,12,14,15-decahydrocyclopenta[a]phenanthrene-3,16-dione pregna-4,17-diene-3,16-dione GUGGULISTERONES 95% CIS-4,17(20)-PREGNADIENE-3,16-DIONE CIS GUGGULSTERONE GUGULSTERONE GUGGULSTERONE Z GUGGULSTERONE (Z FORM) GUGGULESTERONE Z (17Z)-Pregna-4,17(20)-diene-3,16-dione (17E)-Pregna-4,17(20)-diene-3,16-dione GUGGULSTERONES E&Z(MIX)(FG) GuggulsteronesE&Z(mix) (E&Z)-Guggulsterone Guggulsterone E&Z Guggulsterones E&Z (Z)-Guggulsterone Guggulsterone E and Z Stersterone (Z)-Guggulsterone/Guggulsterone GUGGULESTERONES GUGGULSTERONE (GUGG),CAS:95975-55-6 NSC 37445 GUGGULSTERONE Coumarin sterone Guggulsterone(pregna-4,17-diene-3,16-dione) (8R,9S,10R,13S,14S)-17-Ethylidene-10,13-dimethyl-7,8,9,10,11,12,13,14,15,17-decahydro-1H-cyclopenta[a]phenanthrene-3,16(2H,6H)-dione 95975-55-6 Alphabetic Analytical Chromatography Product Catalog Analytical Standards Miscellaneous