Posaconazole Impurity 43

Posaconazole Impurity 43 Structure
CAS No.
357189-95-8
Chemical Name:
Posaconazole Impurity 43
Synonyms
-Diformyl;Posaconazole Impurity 43;Desethylene Posaconazole N,N’-Diformyl;Posaconazole Desethylene Diformyl Impurity;Desethylene Posaconazole N(triazolonophenyl)-Formyl;3,7-Dihydro-3,7-dimethyl-2-[(5-oxohexyl)oxy]-6H-purin-6-one;Posaconazole Impurity B/ Posaconazole Desethylene Diformyl Impurity;N-(4-(((3R,5R)-5-((1H-1,2,4-triazol-1-yl)methyl)-5-(2,4-difluorophenyl)tetrahydrofuran-3-yl)methoxy)phenyl)-N-(2-(N-(4-(1-((2S,3S)-2-hydroxypentan-3-yl)-5-oxo-1H-1,2,4-triazol-4(5H)-yl)phenyl)formamido)ethyl)formamide;N-(4-(((3R,5R)-5-((1H-1,2,4-triazol-1-yl)methyl)-5-(2,4-difluorophenyl)tetrahydrofuran-3-yl)methoxy)phenyl)-N-(2-(N-(4-(1-((2S,3S)-2-hydroxypentan-3-yl)-5-oxo-1,5-dihydro-4H-1,2,4-triazol-4-yl)phenyl)formamido)ethyl)formamide;D-threo-Pentitol, 2,5-anhydro-1,3,4-trideoxy-2-C-(2,4-difluorophenyl)-4-[[4-[[2-[[4-[1-[(1S,2S)-1-ethyl-2-hydroxypropyl]-1,5-dihydro-5-oxo-4H-1,2,4-triazol-4-yl]phenyl]formylamino]ethyl]formylamino]phenoxy]methyl]-1-(1H-1,2,4-triazol-1-yl)-
CBNumber:
CB73359928
Molecular Formula:
C37H40F2N8O6
Molecular Weight:
730.7603064
MOL File:
357189-95-8.mol
Modify Date:
2024/7/11 17:04:31

Posaconazole Impurity 43 Properties

Boiling point 904.9±75.0 °C(Predicted)
Density 1.36±0.1 g/cm3(Predicted)
storage temp. Hygroscopic, -20°C Freezer, Under inert atmosphere
solubility Chloroform (Slightly), Methanol (Slightly)
form Solid
pka 14.72±0.20(Predicted)
color Light Brown to Brown

Posaconazole Impurity 43 Chemical Properties,Uses,Production

Uses

Desethylene Posaconazole N,N’-Diformyl is a degradation product of Posaconazole (P689600), which is an orally active triazole antifungal.

Posaconazole Impurity 43 Preparation Products And Raw materials

Raw materials

Preparation Products

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Desethylene Posaconazole N(triazolonophenyl)-Formyl Desethylene Posaconazole N,N’-Diformyl Posaconazole Impurity 43 Posaconazole Desethylene Diformyl Impurity N-(4-(((3R,5R)-5-((1H-1,2,4-triazol-1-yl)methyl)-5-(2,4-difluorophenyl)tetrahydrofuran-3-yl)methoxy)phenyl)-N-(2-(N-(4-(1-((2S,3S)-2-hydroxypentan-3-yl)-5-oxo-1H-1,2,4-triazol-4(5H)-yl)phenyl)formamido)ethyl)formamide -Diformyl N-(4-(((3R,5R)-5-((1H-1,2,4-triazol-1-yl)methyl)-5-(2,4-difluorophenyl)tetrahydrofuran-3-yl)methoxy)phenyl)-N-(2-(N-(4-(1-((2S,3S)-2-hydroxypentan-3-yl)-5-oxo-1,5-dihydro-4H-1,2,4-triazol-4-yl)phenyl)formamido)ethyl)formamide Posaconazole Impurity B/ Posaconazole Desethylene Diformyl Impurity N-(4-(((3R,5R)-5-((1H-1,2,4-Triazol-1-yl)methyl)-5-(2,4-difluorophenyl)tetrahydrofuran-3-yl)methoxy)phenyl)-N-(2-(N-(4-(1-((2S,3S)-2-hydroxypentan-3-yl)-5-oxo-1H-1,2,4-triazol-4(5H)-yl)phenyl)formamido)ethyl)formamide (Posaconazole Impurity) D-threo-Pentitol, 2,5-anhydro-1,3,4-trideoxy-2-C-(2,4-difluorophenyl)-4-[[4-[[2-[[4-[1-[(1S,2S)-1-ethyl-2-hydroxypropyl]-1,5-dihydro-5-oxo-4H-1,2,4-triazol-4-yl]phenyl]formylamino]ethyl]formylamino]phenoxy]methyl]-1-(1H-1,2,4-triazol-1-yl)- 3,7-Dihydro-3,7-dimethyl-2-[(5-oxohexyl)oxy]-6H-purin-6-one 357189-95-8