INSULIN
- CAS No.
- 11061-68-0
- Chemical Name:
- INSULIN
- Synonyms
- INSULIN, RECOMBINANT HUMAN;INSULIN HUMAN;rh-Insulin;Insulin (human) CRS;D03230;Umulin;novolin;Humulin;INSULIN;humuline
- CBNumber:
- CB7336087
- Molecular Formula:
- C257H383N65O77S6
- Molecular Weight:
- 0
- MOL File:
- Mol file
- Modify Date:
- 2024/7/4 14:04:14
| Melting point | >200°C (dec.) |
|---|---|
| storage temp. | -20°C |
| solubility | acidified water, pH 2.0: 2 mg/mL |
| form | solution |
| color | White |
| Water Solubility | Soluble up to 10mg/ml in pH <3 or in the presence of surfactants. Adjusting pH with a volatile acid (such as formic acid) prior to dry down will allow the product to be re-dissolved in water. |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
| Safety Statements | 22-24/25 |
| WGK Germany | 3 |
| RTECS | NM8900250 |
| F | 3-10 |
| HS Code | 2937120000 |
| Toxicity | LD50 intraperitoneal in mouse: 3937units/kg |
INSULIN price More Price(13)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | I9278 | Insulin solution human sterile-filtered, BioXtra, suitable for cell culture | 11061-68-0 | 5ML | ₹6386.75 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | I2643 | Insulin human recombinant, expressed in yeast (proprietary host) | 11061-68-0 | 25MG | ₹17114.33 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | I2643 | Insulin human recombinant, expressed in yeast (proprietary host) | 11061-68-0 | 50MG | ₹21541.75 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | I3536 | Insulin human recombinant, expressed in yeast, γ-irradiated, suitable for cell culture | 11061-68-0 | 100MG | ₹71412.53 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | I2643 | Insulin human recombinant, expressed in yeast (proprietary host) | 11061-68-0 | 250MG | ₹74313.63 | 2022-06-14 | Buy |
INSULIN Chemical Properties,Uses,Production
Chemical Properties
White or almost white powder.
Uses
Insulin shows a broad range of activities on a variety of somatic cells. Recombinant human insulin can be used to stimulate growth and proliferation of cultured cells and to investigate insulin activity on sensitive cells used in research studies. It is also a component of serum-free media formulations for most primary cells and cell lines.
General Description
The INS gene encodes for preproinsulin, which is enzymatically converted into insulin. Insulin is produced in the insulin-producing pancreatic β cells. Preproinsulin is converted to proinsulin in ER and proinsulin is then proteolytically processed to form insulin in newly-forming insulin secretory granules. Insulin production is tightly regulated by specific DNA elements present within ～400 bp in the proximal region of the INS promoter.
Structure and conformation
Human preproINS consists of 110 aa residues: 24 in the
signal peptide, 30 in the B-chain, 31 in the C-peptide, and
21 in the A-chain. The signal peptide and
C-peptide are excised from the preproINS to produce
the mature peptide, consisting of heterodimeric A- and
B-chains. Six cysteine residues are conserved throughout evolution from agnathans to mammals. Furthermore, the N-terminal seven aa residues of the A-chain
and the receptor binding region of the B-chain (Gly-Phe-Phe-Tyr) are highly conserved. Mr 5808, pI 5.3. INS is soluble under acidic and alkaline
conditions and almost insoluble at neutral pH. INS can be
stored for up to 6 months at 4°C in 1M acetic acid. Long-term
storage at an alkaline pH increases the rate of deamidation
and aggregation. One IU is equivalent to 0.0347mg
human INS.
INSULIN Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| Sisco Research Laboratories Pvt. Ltd. | +91-22-4268 5800 | Mumbai, India | 4317 | 58 | Inquiry |
| Pharmaffiliates Analytics and Synthetics P. Ltd | +91-172-5066494 | Haryana, India | 6773 | 58 | Inquiry |
| Triveni chemicals | 08048762458 | New Delhi, India | 6093 | 58 | Inquiry |
| Pharma Affiliates | 172-5066494 | Haryana, India | 6761 | 58 | Inquiry |
| Nanjing Duly Biotech Co.,Ltd | +undefined18013301590 | China | 2452 | 58 | Inquiry |
| Shanghai Getian Industrial Co., LTD | +86-15373193816 +86-15373193816 | China | 274 | 58 | Inquiry |
| Shanghai Likang New Materials Co., Limited | +86-16631818819 +86-17736933208 | China | 9311 | 58 | Inquiry |
| Binzhou Lita Trading Co.,Ltd | +undefined86-15060109376 | China | 35 | 58 | Inquiry |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | China | 21676 | 55 | Inquiry |
| career henan chemical co | +86-0371-86658258 +8613203830695 | China | 29901 | 58 | Inquiry |
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