INSULIN
- CAS No.
- 9004-10-8
- Chemical Name:
- INSULIN
- Synonyms
- INSULIN HUMAN;C00723;LinBit;iletin;Humilin;Musulin;insular;insulyl;iszilin;INSULIN
- CBNumber:
- CB4336086
- Molecular Formula:
- C256H381N65O77S6
- Molecular Weight:
- 5793.54364
- MOL File:
- 9004-10-8.mol
- Modify Date:
- 2024/4/23 16:18:34
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS08 |
|---|---|
| Signal word | Danger |
| Hazard statements | H334 |
| Precautionary statements | P261-P285-P304+P341-P342+P311-P501 |
| Safety Statements | 22-24/25 |
| WGK Germany | 3 |
| RTECS | NM8900250 |
| F | 3-10 |
INSULIN Chemical Properties,Uses,Production
Description
Insulin is a polypeptide hormone that consists of two peptide chains bonded by two disulfide
bonds. The two chains are designated A and B. The A chain consists of 21 amino acids with
a third internal disulfidebond, and the B chain contains the remaining 30 amino acids. All
vertebrates produce insulin and the structure is similar in these species. For example, the insulin
produced in humans and porcine species differs by only one amino acid, and humans and
bovine insulin differ by three amino acids. Insulin plays a crucial role in several physiological
processes. These include the regulation of sugar in the body, fatty acid synthesis, formation of
triglycerides, and amino acid synthesis.
Insulin also promotes the storage of glucose as glycogen
in the liver. In this manner, insulin maintains glucose at a stable level in the bloodstream.
Insulin is most closely associated with diabetes. Diabetes results in excess blood glucose
levels (hyperglycemia) and the inability of cells to absorb glucose, which in turn deprives them
of energy.
History
Insulin derives its name from the Latin word insula for island. Insulin is produced in the
pancreas by β-cells in the islets of Langerhans (α-cells in the pancreas produce glucagon). Paul
Langerhans (1847–1888) discovered the islets of Langerhans, which were subsequently shown
to secrete insulin. Insulin binds to insulin receptors on cells and produces biochemical changes
that allow the cells to take in glucose.
Diabetes has been prevalent in humans throughout history, but relief from the disease was
not available until the 20th century.The termdiabetes comes from the Greek words diabainein,
meaning to pass through or siphon.In the late 1800s,it was known that diabetes was related to the pancreas,but it was not known exactly how. In 1901, Eugene Opie
(1873–1971) determined that diabetes was related to the islets of Langerhans. During the
early 20th century, knowledge was advanced on ductless glands and endocrine secretions that
fed directly into the bloodstream.Diseases were treated with extracts obtained from glands.
Uses
Insulin plays a crucial role in several physiologicalprocesses. These include the regulation of sugar in the body, fatty acid synthesis, formation oftriglycerides, and amino acid synthesis.=Insulin also promotes the storage of glucose as glycogenin the liver. In this manner, insulin maintains glucose at a stable level in the bloodstream.Insulin is most closely associated with diabetes.
Diabetes must be managed by monitoring blood sugarlevels throughout the day, and using this information to adjust the diet and activities to keepblood glucose in an acceptable range; Insulin is usually administered through injections, but it can be deliveredusing other methods. Insulin pumps are small electronic devices that deliver insulin accordingto a programmed schedule throughout the day. In recent years oral sprays have beendeveloped to augment but not replace injected insulin. Another area of interest is deliveryusing dermal patches. Insulin cannot be delivered using conventional pills because stomachacidity denatures insulin. Although lack of insulin results in hyperglycemia,it is importantwhen administering insulin to prevent hypoglycemia. In hypoglycemia blood sugar is too low.Hypoglycemia in diabetics can occur from too much insulin, lack of food, exercise, or lackof carbohydrates. Its symptoms include increased heart rate, nervousness, perspiration, andshakiness. When this condition is recognized, diabetics consume carbohydrates such as candy,fruit,or fruit juice to boost blood sugar levels. In extreme cases,a person can have a severereaction and experience seizures or fall into a coma. Severe reaction to insulin is referred toas insulin shock.
Definition
ChEBI: A peptide hormone produced in the pancreas and involved in regulating the metabolism of carbohydrates (particularly glucose) and fats. Commonly thought of as a protein, it consists of two petide chains, one containing 21 amino acid residues and the other c ntaining 30; the chains are joined together by 2 disulfide bonds. Recombinant insulin is identical to human insulin, but is synthesised by inserting the human insulin gene into E. coli, which then produces insulin for human use. It is used in he treatment of type I and type II diabetes.
INSULIN Preparation Products And Raw materials
Raw materials
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chevron_rightPreparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| ARCTIC EXPORTS INC | +1-3026880818 +1-3026880818 | Canada | 68 | 58 | Inquiry |
| CONTIDE BIOTECH CO.,LTD | +852-53358525 | China | 586 | 58 | Inquiry |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | China | 21675 | 55 | Inquiry |
| Hefei TNJ Chemical Industry Co.,Ltd. | 0551-65418671 | China | 34571 | 58 | Inquiry |
| Shaanxi Dideu Medichem Co. Ltd | +86-029-89586680 +86-18192503167 | China | 9030 | 58 | Inquiry |
| AFINE CHEMICALS LIMITED | +86-0571-85134551 | China | 15395 | 58 | Inquiry |
| ZHEJIANG JIUZHOU CHEM CO., LTD | +86-0576225566889 +86-13454675544 | China | 19947 | 58 | Inquiry |
| Apeloa production Co.,Limited | +8619933239880 | China | 853 | 58 | Inquiry |
| Wuhan kemike Biomedical Technology Co., Ltd | 027-13163388153 13163388153 | China | 9968 | 58 | Inquiry |
| Shanghai Huzhen Industrial Co., LTD | 021-60345367 13916550749 | China | 9965 | 58 | Inquiry |
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