Triacetin
- CAS No.
- 102-76-1
- Chemical Name:
- Triacetin
- Synonyms
- GLYCEROL TRIACETATE;Triacetine;GLYCERYL TRIACETATE;triacetate;GLYCERIN TRIACETATE;Vanay;Enzactin;Fungacetin;1,2,3-TRIACETOXYPROPANE;1,2,3-PROPANETRIOL TRIACETATE
- CBNumber:
- CB7441695
- Molecular Formula:
- C9H14O6
- Molecular Weight:
- 218.2
- MOL File:
- 102-76-1.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/5/20 18:13:44
| Melting point | 3 °C(lit.) |
|---|---|
| Boiling point | 258-260 °C(lit.) |
| Density | 1.16 g/mL at 25 °C(lit.) |
| vapor density | 7.52 (vs air) |
| vapor pressure | 0.00248 mm Hg @ 250C |
| FEMA | 2007 | (TRI-)ACETIN |
| refractive index |
n |
| Flash point | 300 °F |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | Soluble in water, miscible with ethanol (96 per cent) and toluene. |
| form | Liquid |
| color | Clear colorless |
| Odor | Characteristic odour |
| explosive limit | 1.05%, 189°F |
| Odor Type | fruity |
| Water Solubility | 64.0 g/L (20 ºC) |
| Merck | 14,9589 |
| JECFA Number | 920 |
| BRN | 1792353 |
| Dielectric constant | 7.2（20℃） |
| Stability | Stable. Incompatible with strong oxidizing agents. Combustible. |
| InChIKey | URAYPUMNDPQOKB-UHFFFAOYSA-N |
| LogP | 0.25 |
| CAS DataBase Reference | 102-76-1(CAS DataBase Reference) |
| NIST Chemistry Reference | 1,2,3-Propanetriol, triacetate(102-76-1) |
| EPA Substance Registry System | Glyceryl triacetate (102-76-1) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H303 | |||||||||
| Precautionary statements | P270-P301+P312-P403-P501c | |||||||||
| Safety Statements | 23-24/25 | |||||||||
| WGK Germany | 1 | |||||||||
| RTECS | AK3675000 | |||||||||
| Autoignition Temperature | 809 °F | |||||||||
| TSCA | Yes | |||||||||
| HS Code | 29153930 | |||||||||
| Toxicity | LD50 i.v. in mice: 1600 ±81 mg/kg (Wretlind) | |||||||||
| NFPA 704 |
|
Triacetin price More Price(24)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | W200712 | Triacetin ≥99%, natural, FG | 102-76-1 | 1SAMPLE-K | ₹5196 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | W200712 | Triacetin ≥99%, natural, FG | 102-76-1 | 1KG | ₹12026.58 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | W200712 | Triacetin ≥99%, natural, FG | 102-76-1 | 10KG | ₹72159.45 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | W200700 | Triacetin 99%, FCC, FG | 102-76-1 | 1SAMPLE-K | ₹5141.88 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | W200700 | Triacetin 99%, FCC, FG | 102-76-1 | 1KG | ₹7447.6 | 2022-06-14 | Buy |
Triacetin Chemical Properties,Uses,Production
Description
§ 184.1901(a) Triacetin (C8H14O6), also known as 1,2,3-propanetriol triacetate or glyceryl triacetate, is the triester of glycerin and acetic acid. Triacetin can be prepared by heating glycerin with acetic anhydride alone or in the presence of finely divided potassium hydrogen sulfate. It can also be prepared by the reaction of oxygen with a liquid-phase mixture of allyl acetate and acetic acid using a bromide salt as a catalyst.
Chemical Properties
Triacetin is a colorless, viscous liquid with a slightly fatty odor.
Occurrence
Reported found in papaya.
Uses
As fixative in perfumery; solvent in manufacture of celluloid, photographic films. Technical triacetin (a mixture of mono-, di-, and small quantities of triacetin) as a solvent for basic dyes, particularly indulines, and tannin in dyeing.
Preparation
By direct reaction of glycerol with acetic acid in the presence of Twitchell’s reagent, or in benzene solution of glycerol and boiling acetic acid in the presence of a cationic resin (Zeo-Karb H) pretreated with dilute H2SO4.
Production Methods
Triacetin is prepared by the esterification of glycerin with acetic anhydride.
Definition
ChEBI: A triglyceride obtained by acetylation of the three hydroxy groups of glycerol. It has fungistatic properties (based on release of acetic acid) and has been used in the topical treatment of minor dermatophyte infections.
General Description
Triacetin is a triester of glycerin and acetic acid that occurs naturally in papaya. It is mainly used as a synthetic flavoring agent in ice-creams, nonalcoholic beverages and baked goods.
Pharmaceutical Applications
Triacetin is mainly used as a hydrophilic plasticizer in both aqueous
and solvent-based polymeric coating of capsules, tablets, beads, and
granules; typical concentrations used are 10–35% w/w.
Triacetin is used in cosmetics, perfumery, and foods as a solvent
and as a fixative in the formulation of perfumes and flavors.
Contact allergens
Triacetin is a component of cigarette filters, which induced a contact dermatitis in a worker at a cigarette manufactory.
Clinical Use
Glyceryl triacetate (Enzactin, Fungacetin) is a colorless, oilyliquid with a slight odor and a bitter taste. The compound issoluble in water and miscible with alcohol and most organicsolvents.
The activity of triacetin is a result of the acetic acid releasedby hydrolysis of the compound by esterases presentin the skin. Acid release is a self-limiting process becausethe esterases are inhibited below pH 4.
Safety Profile
Poison by ingestion. Moderately toxic by intraperitoneal, subcutaneous, and intravenous routes. An eye irritant. Combustible when exposed to heat, flame, or powerful oxidizers. To fight fire, use alcohol foam, water, CO2, dry chemical. When heated to decomposition it emits acrid smoke and irritating fumes.
Safety
Triacetin is used in oral pharmaceutical formulations and is
generally regarded as a relatively nontoxic and nonirritant material
at the levels employed as an excipient.
LD50 (dog, IV): 1.5 g/kg
LD50 (mouse, IP): 1.4 g/kg
LD50 (mouse, IV): 1.6 g/kg
LD50 (mouse, oral): 1.1 g/kg
LD50 (mouse, SC): 2.3 g/kg
LD50 (rabbit, IV): 0.75 g/kg
LD50 (rat, IP): 2.1 g/kg
LD50 (rat, oral): 3 g/kg
LD50 (rat, SC): 2.8 g/kg
in vitro
Litton Bionetics, Inc. (1976) evaluated the mutagenic potential of Triacetin in a plate test using Salmonella typhimurium
strains TA1535, TA1537, and TA1538 with and without metabolic activation. Test concentrations were 0.0013%, 0.00065%,
and 0.000325% and the solvent was dimethyl sulfoxide (DMSO).
A negative control (solvent) and appropriate positive controls
were used and gave expected results. Triacetin was not mutagenic with or without metabolic activation.
Unichema Chemie B.V. (1994) reported that Triacetin was
not mutagenic at 50 to 5000 μg/plate in an Ames test using S.
typhimurium strains TA1535, TA1537, TA98, and TA100 with
and without metabolic activation.
in vivo
The mutagenic potential of Triacetin was determined using adult Drosophila melanogaster (Efremova 1962). A dose of 0.2 to 0.3 mg Triacetin had a spontaneous mutation rate of approximately one mutation per 750 chromosomes.
storage
Triacetin is stable and should be stored in a well-closed, nonmetallic container, in a cool, dry place.
Incompatibilities
Triacetin is incompatible with metals and may react with oxidizing agents. Triacetin may destroy rayon fabric.
Regulatory Status
GRAS listed. Accepted in Europe as a food additive in certain applications. Included in the FDA Inactive Ingredients Database (oral capsules and tablets and gels). Included in nonparenteral medicines licensed in the UK. Included in the Canadian List of Acceptable Non-medicinal Ingredients.
Triacetin Preparation Products And Raw materials
Raw materials
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chevron_rightPreparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| ULTIMA CHEMICALS | +91 7208029458 | Mumbai, India | 95 | 58 | Inquiry |
| MRIB CHEMICALS | +91 9820666556 | Mumbai, India | 5 | 58 | Inquiry |
| oswal chemicals | +91-9173644055 +91-9173644055 | Gujarat, India | 66 | 58 | Inquiry |
| Sagar Speciality Chemicals Private Limited | +91-9619603699 +91-9619603699 | Maharashtra, India | 48 | 58 | Inquiry |
| PAARICHEM RESOURCES LLP | +91-8104961021 +91-8104961021 | Maharashtra, India | 82 | 58 | Inquiry |
| SOMU Solvents Pvt.Ltd | +91-8026783595 +91-8026783595 | Karnataka, India | 17 | 58 | Inquiry |
| Loba Chemie Pvt., Ltd. | 91-22-66636663 | Maharashtra, India | 766 | 58 | Inquiry |
| Clearsynth Labs | 91-22-45045900 | Maharashtra, India | 3889 | 58 | Inquiry |
| Flora Chemicals | 09223433436 | Mumbai, India | 22 | 58 | Inquiry |
| Multichem Specialities Private Limited. | 91-22-43432121 | Maharashtra, India | 127 | 58 | Inquiry |
| Supplier | Advantage |
|---|---|
| ULTIMA CHEMICALS | 58 |
| MRIB CHEMICALS | 58 |
| oswal chemicals | 58 |
| Sagar Speciality Chemicals Private Limited | 58 |
| PAARICHEM RESOURCES LLP | 58 |
| SOMU Solvents Pvt.Ltd | 58 |
| Loba Chemie Pvt., Ltd. | 58 |
| Clearsynth Labs | 58 |
| Flora Chemicals | 58 |
| Multichem Specialities Private Limited. | 58 |
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